How many people still use Sema?

[andreigl]

Did you ever up your Tirz?

Yep. Already started my 16th week and new dose is pure 10mg tirz at the moment and plan to stick to this dose for 8 weeks with 4th to 8th week stacked with increasing sema dose again. Because tirz loses suppression for me. Although, I have noticed at these higher tirz doses, I always feel full already half way through a meal. I couldn't force myself to finish because I feel my stomach will burst. Funny, ain't it? We know it can hold twice as much food.

 

[50ShadesGreyMarket]

I ordered from SSA a little over a month ago and in order to get the amount high enough to use a bank wire I bought way more than I thought I’d need of both Sema and Reta. At my current dose, I have a little over 46 years worth of Sema so it looks like I’m gonna be stacking it for the long haul. 😂

 

[andreigl]

I ordered from SSA a little over a month ago and in order to get the amount high enough to use a bank wire I bought way more than I thought I’d need of both Sema and Reta. At my current dose, I have a little over 46 years worth of Sema so it looks like I’m gonna be stacking it for the long haul. 😂

Or.... you could sell that sema at discount in Asia. In Thailand, it's 5,000 baht per 22mg sema vial. Add label to look pro.

 

[Mastodon]

I take 1mg of sema and have recently added 1mg of reta. No complaints.

Do you draw in the same syringe or its 2 diff shots?

 

[MsGizmo]

Do you draw in the same syringe or its 2 diff shots?

2 different shots 3 days apart

 

[50ShadesGreyMarket]

Or.... you could sell that sema at discount in Asia. In Thailand, it's 5,000 baht per 22mg sema vial. Add label to look pro.

I live in the US, would prefer give it away to folks I know, maybe those who can’t justify the cost of prescriptions. Selling it wouldn’t make enough money to justify the time spent as well as the risk associated. :/

 

[Miles]

What I have read several times recently is that many people inject sema in addition to reta.
Is that common? Because reta doesn't suppress the feeling of hunger as much sema do?
I am still relatively new to this subject...🤓

 

[MsGizmo]

What I have read several times recently is that many people inject sema in addition to reta.
Is that common? Because reta doesn't suppress the feeling of hunger as much sema do?
I am still relatively new to this subject...🤓

Well I started with sema, and since I am taking such a low dose anyway (1mg) I just added the reta in so I don't know how reta feels on its own.

 

[Miles]

A short experience report from me. I started with 0.5 mg of Reta, injected it on Sunday evening, and by Thursday I was feeling hungry, and on Friday it was even worse. On Saturday and Sunday, it was as if I had never taken Reta. So I decided to order Sema. The following week, I took Reta again on Sunday evening and this time Sema on Thursday evening, 0.25 dose. The appetite suppression was so intense after Sema, just unbelievable. That's how I imagined it would be with Reta. This is my first week with Reta and Sema and I am totally happy.

 

[Airborne Daddy]

A short experience report from me. I started with 0.5 mg of Reta, injected it on Sunday evening, and by Thursday I was feeling hungry, and on Friday it was even worse. On Saturday and Sunday, it was as if I had never taken Reta. So I decided to order Sema. The following week, I took Reta again on Sunday evening and this time Sema on Thursday evening, 0.25 dose. The appetite suppression was so intense after Sema, just unbelievable. That's how I imagined it would be with Reta. This is my first week with Reta and Sema and I am totally happy.

Alot of us stack reta with sema ...

 

[YoYoFat]

I was first put on Pasireotide after getting a brain tumor removed in 2022. My endocrinologist has been using Sema off label for some patients for various reasons, in my case it’s to increase levels of Akkermansia muciniphila in my gut after having been on countless pharmaceuticals for the past few years. I decided to switch from a clinic to grey market recently due to the ridiculously high costs. Long-term I plan to microdose Sema and Reta in addition to all the other peptides I’m on (GLOW, NAD+, etc). There are so many benefits outside of weight loss, that’s what drew me to Sema and that’s why I’ll probably keep it in my arsenal.

You’re using peps that promote angiogenesis after having had a brain tumor? That doesn’t seem wise.

 

[YoYoFat]

A short experience report from me. I started with 0.5 mg of Reta, injected it on Sunday evening, and by Thursday I was feeling hungry, and on Friday it was even worse. On Saturday and Sunday, it was as if I had never taken Reta. So I decided to order Sema. The following week, I took Reta again on Sunday evening and this time Sema on Thursday evening, 0.25 dose. The appetite suppression was so intense after Sema, just unbelievable. That's how I imagined it would be with Reta. This is my first week with Reta and Sema and I am totally happy.

It’s my understanding that Reta’s appetite suppression doesn’t kick in until high doses, and that at doses like yours, it actually increases hunger. So your experience and plan makes sense.

 

[YoYoFat]

I tried stacking Sema early on but didn’t see much benefit, so I stuck with straight Tirz.

I’m now in maintenance, but considering adding a smidge of Sema for its benefits beyond appetite suppression. All of the studies about all the non-weight loss benefits of GLP1s are focused on the GLP1RA mechanism, not the GIP, not the GCGR — the GLP1. Not that the latter doesn’t help, but it seems the GLP1 part is worth keeping around first and foremost.

 

[FitnessWannabe]

She is very  apprehensive about transitioning to gray. But her hands are kinda tied as her pharm is closing. She questions the legality of things mainly, and I've been explaining that as they are not controlled substances there is no legal concern for possessing them, rather that its questionable how it makes it through customs. She finally decided she is okay with trying it and I'm sourcing a kit for her. She was spending $300/m and is skeptical since $300 could get her 5 years worth at her current dose. She likely won't use any other peps, but I'll be there to walk her through it if that changes

If she's worried about customs, just find a seller who can ship from a U.S. warehouse. That's what I did after I had an order seized in customs and lost my money this summer. I said never again. If the seller doesn't have a warehouse in the states, I don't deal with them.

Having a package seized in customs is scary. You start getting all these official scary looking letters from the FDA about your illegal package. They disposed of my contents and sent me a letter to let me know and I moved on gladly. So no GLPs for me from China. And once you have a package seized by the FDA through customs, your address goes into a database that makes it easier for the government to flag your international shipments if they appear suspicious. So I'm done with that.

 

[MeedzMoar]

I'm participating in a GB, and was gojng to pick up a kot of S10 for my girlfriend because her compounding pharmacy is closing due to some kind of lawsuit. I was looking at the Google sheet for the buy and noticed myself and two others is all that wanted sema, but there's hundreds going for tirz and reta. How many people still use sema, and out of those people, how many source Grey for it?

I'm still testing sema. It was successful for my RS so continued with it. I may have maxed it out. If it works, why make a change?

 

[MrZardoz]

I also use Sema ( 2mg) to stack with my Tirz (currently on 20mg in 5 day cycles)

 

[Foggy-Hollow]

At my current dose, I have a little over 46 years worth of Sema

Sounds about average for this place! 😍😊

 

[Enyola]

I don't use it (or anything else) yet, but if my delivery gets through and tests ok, I will be using sema as long as it works and only then switch to tirz. From experience of others I have seen that it usually works well this direction, but not necessarily so well the opposite direction, from tirz to sema. I am not keen on the latest and supposed greatest or mixing at the moment, I just want an effect and a long term concept. I might get interested in mixing later, but first I want to get a feel for what each peptide mono does.

 

[MeedzMoar]

I don't use it (or anything else) yet, but if my delivery gets through and tests ok, I will be using sema as long as it works and only then switch to tirz. From experience of others I have seen that it usually works well this direction, but not necessarily so well the opposite direction, from tirz to sema. I am not keen on the latest and supposed greatest or mixing at the moment, I just want an effect and a long term concept. I might get interested in mixing later, but first I want to get a feel for what each peptide mono does.

Wishing you much success and welcome!

 

[Nmcoyote1]

Well I started with sema, and since I am taking such a low dose anyway (1mg) I just added the reta in so I don't know how reta feels on its own.

I saw some of you comments and decided to try it a few weeks ago. I was stalled on Sema 3mg in May 2025 added Cagri and had severe constipation even at micro doses. Tried Reta, it did not work for me even at 12mg. So I went back to Sema 1mg last year and tried maintaining. I started stacking Sema 1.25mg and 2mg Reta and so far it seems to be working well. Hoping to lose the last 30-40 pounds

 

[CMA Pooky]

Well I started with sema, and since I am taking such a low dose anyway (1mg) I just added the reta in so I don't know how reta feels on its own.

I have been on Reta for over 2 months now and am thinking of adding Sema as I get the hunger pangs on Reta usually around 4 days after taking my Reta dose. Any opinion or thoughts on what my starting Sema dose should be since I am already accustomed to being on Reta? I was thinking .5mg possibly?

 

[AxlBundy]

I added in Sema at .5 after 14 weeks of Reta alone and that was a fine place to start. To me, it just feels closer to what I expected Reta to be like. Nothing crazy

 

[woundcarping]

Have you considered split dosing your Reta instead of stacking?

 

[MsGizmo]

I have been on Reta for over 2 months now and am thinking of adding Sema as I get the hunger pangs on Reta usually around 4 days after taking my Reta dose. Any opinion or thoughts on what my starting Sema dose should be since I am already accustomed to being on Reta? I was thinking .5mg possibly?

I'm not a doctor. All I can do is remind you that the starting dose of sema is .25mg. I can say that even at that small of a dose when I first started taking it I had some constipation issues. What you end up taking is your decision because you are the one that has to deal with with the consequences.

 

[CMA Pooky]

Have you considered split dosing your Reta instead of stacking?

I initially gave it some thought but Dr. Kevin Joseph on YT mentioned splitting the dose can desensitize the receptors faster. Adding Sema might not be the best idea either, but Sema only affects 1 pathway, while Reta affects 3 pathways.

 

[woundcarping]

I initially gave it some thought but Dr. Kevin Joseph on YT mentioned splitting the dose can desensitize the receptors faster. Adding Sema might not be the best idea either, but Sema only affects 1 pathway, while Reta affects 3 pathways.

Watching his video here, mainly the part on split dosing this time, I've watched the video before.

Split dosing dose not affect your average exposure, but it absolutely suppresses peaks and raises troughs. I posted about the math here showing average exposure is the same, but peaks and troughs are less extreme.

"-If you take the 1mg twice a week, you end up with a peak of 3mg, trough of 2mg, and average of 2.5mg.
-If you take .285mg daily, the peak is 2.62mg, trough is 2.33mg, and the average is still 2.5mg.
-If you take 4mg every other week, the peak is 5mg, the trough is 1mg, and the average is still 2.5mg."


He says split dosing sends more receptors to the lysosome because they get burnt out, but doesn't go on to explain that logic. We agree the average concentration is the same. There is an argument that lower troughs between doses allows them time to replenish, but what about the higher peaks "burning them out" (if that's a thing)... still, the steady state/average exposure isn't different.


I've said that symptoms track peaks and troughs determine efficacy. By split dosing, so far, I have kept my adverse side effects minimal to non existent. I've controlled appetite (less of a problem for me), food noise (more of a problem for me), showing solid weight (presumably fat) loss, still eating generally appropriate macros without undue struggle, and maintaining enough capacity to burn at least 500 calories a day exercising on top of my general daily life.


I am transitioning from Tirz to Reta. I started split dosing 3.5 weeks in to my Tirz 2.5mg dose when food noise came back mid week, I took the 4th dose then and started my move to 5mg/week split dosing before starting the transition to Reta. My highest peak on Tirz has been 5.6mg, my highest peak on Reta has been 5.7mg. I'm currently down 18lb in 40 days which is slightly ahead of my intended slope but well within the tolerance of the range. I anticipate being off Tirz injections sometime next month, but I'm just along for the ride.


What is your current Reta dose and levels?

 

[Wecandothis]

Have you considered split dosing your Reta instead of stacking?

I do split my Reta dose twice a week, and I stack too

 

[Laxfinity]

I stack. I have been on sema for over 3 years now. It is the only thing that gets rid of the actual food noise for me.

 

[CMA Pooky]

Watching his video here, mainly the part on split dosing this time, I've watched the video before.

Split dosing dose not affect your average exposure, but it absolutely suppresses peaks and raises troughs. I posted about the math here showing average exposure is the same, but peaks and troughs are less extreme.

"-If you take the 1mg twice a week, you end up with a peak of 3mg, trough of 2mg, and average of 2.5mg.
-If you take .285mg daily, the peak is 2.62mg, trough is 2.33mg, and the average is still 2.5mg.
-If you take 4mg every other week, the peak is 5mg, the trough is 1mg, and the average is still 2.5mg."


He says split dosing sends more receptors to the lysosome because they get burnt out, but doesn't go on to explain that logic. We agree the average concentration is the same. There is an argument that lower troughs between doses allows them time to replenish, but what about the higher peaks "burning them out" (if that's a thing)... still, the steady state/average exposure isn't different.


I've said that symptoms track peaks and troughs determine efficacy. By split dosing, so far, I have kept my adverse side effects minimal to non existent. I've controlled appetite (less of a problem for me), food noise (more of a problem for me), showing solid weight (presumably fat) loss, still eating generally appropriate macros without undue struggle, and maintaining enough capacity to burn at least 500 calories a day exercising on top of my general daily life.


I am transitioning from Tirz to Reta. I started split dosing 3.5 weeks in to my Tirz 2.5mg dose when food noise came back mid week, I took the 4th dose then and started my move to 5mg/week split dosing before starting the transition to Reta. My highest peak on Tirz has been 5.6mg, my highest peak on Reta has been 5.7mg. I'm currently down 18lb in 40 days which is slightly ahead of my intended slope but well within the tolerance of the range. I anticipate being off Tirz injections sometime next month, but I'm just along for the ride.


What is your current Reta dose and levels?

I am at 4mg but stalled the past week+ and gained about 2 pounds. I will go to 5mg next dose. I am hoping not to eventually go above 6mg. I've read of several members who've had success stacking Reta and Sema. I think I will go that route at some point in February.