How many people still use Sema?

Did you ever up your Tirz?
Yep. Already started my 16th week and new dose is pure 10mg tirz at the moment and plan to stick to this dose for 8 weeks with 4th to 8th week stacked with increasing sema dose again. Because tirz loses suppression for me. Although, I have noticed at these higher tirz doses, I always feel full already half way through a meal. I couldn't force myself to finish because I feel my stomach will burst. Funny, ain't it? We know it can hold twice as much food.
 
I ordered from SSA a little over a month ago and in order to get the amount high enough to use a bank wire I bought way more than I thought I’d need of both Sema and Reta. At my current dose, I have a little over 46 years worth of Sema so it looks like I’m gonna be stacking it for the long haul. 😂
 
I ordered from SSA a little over a month ago and in order to get the amount high enough to use a bank wire I bought way more than I thought I’d need of both Sema and Reta. At my current dose, I have a little over 46 years worth of Sema so it looks like I’m gonna be stacking it for the long haul. 😂
Or.... you could sell that sema at discount in Asia. In Thailand, it's 5,000 baht per 22mg sema vial. Add label to look pro.
 
Or.... you could sell that sema at discount in Asia. In Thailand, it's 5,000 baht per 22mg sema vial. Add label to look pro.
I live in the US, would prefer give it away to folks I know, maybe those who can’t justify the cost of prescriptions. Selling it wouldn’t make enough money to justify the time spent as well as the risk associated. :/
 
What I have read several times recently is that many people inject sema in addition to reta.
Is that common? Because reta doesn't suppress the feeling of hunger as much sema do?
I am still relatively new to this subject...🤓
 
What I have read several times recently is that many people inject sema in addition to reta.
Is that common? Because reta doesn't suppress the feeling of hunger as much sema do?
I am still relatively new to this subject...🤓
Well I started with sema, and since I am taking such a low dose anyway (1mg) I just added the reta in so I don't know how reta feels on its own.
 
A short experience report from me. I started with 0.5 mg of Reta, injected it on Sunday evening, and by Thursday I was feeling hungry, and on Friday it was even worse. On Saturday and Sunday, it was as if I had never taken Reta. So I decided to order Sema. The following week, I took Reta again on Sunday evening and this time Sema on Thursday evening, 0.25 dose. The appetite suppression was so intense after Sema, just unbelievable. That's how I imagined it would be with Reta. This is my first week with Reta and Sema and I am totally happy.
 
A short experience report from me. I started with 0.5 mg of Reta, injected it on Sunday evening, and by Thursday I was feeling hungry, and on Friday it was even worse. On Saturday and Sunday, it was as if I had never taken Reta. So I decided to order Sema. The following week, I took Reta again on Sunday evening and this time Sema on Thursday evening, 0.25 dose. The appetite suppression was so intense after Sema, just unbelievable. That's how I imagined it would be with Reta. This is my first week with Reta and Sema and I am totally happy.
Alot of us stack reta with sema ...
 
I was first put on Pasireotide after getting a brain tumor removed in 2022. My endocrinologist has been using Sema off label for some patients for various reasons, in my case it’s to increase levels of Akkermansia muciniphila in my gut after having been on countless pharmaceuticals for the past few years. I decided to switch from a clinic to grey market recently due to the ridiculously high costs. Long-term I plan to microdose Sema and Reta in addition to all the other peptides I’m on (GLOW, NAD+, etc). There are so many benefits outside of weight loss, that’s what drew me to Sema and that’s why I’ll probably keep it in my arsenal.
You’re using peps that promote angiogenesis after having had a brain tumor? That doesn’t seem wise.
 
A short experience report from me. I started with 0.5 mg of Reta, injected it on Sunday evening, and by Thursday I was feeling hungry, and on Friday it was even worse. On Saturday and Sunday, it was as if I had never taken Reta. So I decided to order Sema. The following week, I took Reta again on Sunday evening and this time Sema on Thursday evening, 0.25 dose. The appetite suppression was so intense after Sema, just unbelievable. That's how I imagined it would be with Reta. This is my first week with Reta and Sema and I am totally happy.
It’s my understanding that Reta’s appetite suppression doesn’t kick in until high doses, and that at doses like yours, it actually increases hunger. So your experience and plan makes sense.
 
I tried stacking Sema early on but didn’t see much benefit, so I stuck with straight Tirz.

I’m now in maintenance, but considering adding a smidge of Sema for its benefits beyond appetite suppression. All of the studies about all the non-weight loss benefits of GLP1s are focused on the GLP1RA mechanism, not the GIP, not the GCGR — the GLP1. Not that the latter doesn’t help, but it seems the GLP1 part is worth keeping around first and foremost.
 
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