HRT, GLP1s, and other peptides--please share

HistLady

GLP-1 Apprentice
Member Since
Apr 20, 2026
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Hello all,
I am on my eleventh week on a low dose of Reta (currently 1.8 mg per week). After much consideration, I started HRT today (estradiol patch and my first dose of progesterone later tonight). I am supposed to dose Reta tomorrow morning. I want to know if anyone is on both HRT, Reta, or any other peptides like GHK-cu. What are your experiences? Any information welcome. Thanks!
 
I'm on HRT (and Tirz) myself, started by using the patch, and eventually after a few months, where I got tired of paying a little over $100 for just x4 patches, each time - I started with vial-based estradiol instead, and never looked back.
Along the way I've been using Tirz systematically - and tried Reta (which had no effect on me, unfortunately ) and never had any problems with HRT and Tirz, or any of the assorted other peptides I tried, along the way. I will say that - from what I've read - on Reddit - I'm working on only doing progesterone after about a year of HRT under my belt. (I'm only about 5 months in, so far) My 2 cents worth 🙂
 
HistLady said:
Hello all,
I am on my eleventh week on a low dose of Reta (currently 1.8 mg per week). After much consideration, I started HRT today (estradiol patch and my first dose of progesterone later tonight). I am supposed to dose Reta tomorrow morning. I want to know if anyone is on both HRT, Reta, or any other peptides like GHK-cu. What are your experiences? Any information welcome. Thanks!
Click to expand...
My wife is on both Triz and GK and HRT she has lost 30lbs and her hair is looking like it is going back to her natural color as for skin it hard to say because she does alot of stuff along with Botox but nothing negative to say. Also as a side note if you are not taking large doses of L-Arginine you should start it is great for us all but really GREAT for a woman as she gets into the changes, it helps you make Nitric oxide which is very important for your lady bits...
 
HistLady said:
Hello all,
I am on my eleventh week on a low dose of Reta (currently 1.8 mg per week). After much consideration, I started HRT today (estradiol patch and my first dose of progesterone later tonight). I am supposed to dose Reta tomorrow morning. I want to know if anyone is on both HRT, Reta, or any other peptides like GHK-cu. What are your experiences? Any information w
Click to expand...
Fabulous timing. I literally just read this 10 minutes ago.
https://drmaryclairehaver.suspiciou...233_tv2_tp1_a1demonfquwpkn&triedRedirect=true
 
HistLady said:
Hello all,
I am on my eleventh week on a low dose of Reta (currently 1.8 mg per week). After much consideration, I started HRT today (estradiol patch and my first dose of progesterone later tonight). I am supposed to dose Reta tomorrow morning. I want to know if anyone is on both HRT, Reta, or any other peptides like GHK-cu. What are your experiences? Any information welcome. Thanks!
Click to expand...
Yes I am! Ive been on Hrt for 2 plus years. I started reta in oct last year theb added klow a week later. In jan I started tesamoralin and my wasn't shrunk, I gained leaned tissue. My Hrt wasnt working as good all of a sudden and I realized its because I lost more fat/fluid and transdermal need fat for absorption so Increased my E2 patch. I got uglies from ghk-cu on its own amd somewhat from klow.
 
MrZardoz said:
I'm on HRT (and Tirz) myself, started by using the patch, and eventually after a few months, where I got tired of paying a little over $100 for just x4 patches, each time - I started with vial-based estradiol instead, and never looked back.
Along the way I've been using Tirz systematically - and tried Reta (which had no effect on me, unfortunately ) and never had any problems with HRT and Tirz, or any of the assorted other peptides I tried, along the way. I will say that - from what I've read - on Reddit - I'm working on only doing progesterone after about a year of HRT under my belt. (I'm only about 5 months in, so far) My 2 cents worth 🙂
Click to expand...
Why only a year for progesterone? Also, what other peptides have you tried and what were the outcomes if you do not mind sharing? Thanks.
 
BlueDog55 said:
My wife is on both Triz and GK and HRT she has lost 30lbs and her hair is looking like it is going back to her natural color as for skin it hard to say because she does alot of stuff along with Botox but nothing negative to say. Also as a side note if you are not taking large doses of L-Arginine you should start it is great for us all but really GREAT for a woman as she gets into the changes, it helps you make Nitric oxide which is very important for your lady bits...
Click to expand...
How large is large doses?
 
HistLady said:
Why only a year for progesterone? Also, what other peptides have you tried and what were the outcomes if you do not mind sharing? Thanks.
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Well, I think I might be using HRT (and specifically progesterone) for different purposes to some of the others - in my case its to aid breast development during transition 🙂 Regarding other peptides I've tried - off the top of my head: AOD, Semaglutide, PT141, Cagril.. - as well as Retatrutide. Essentially, none of the others I tried so far seemed to do much - so I tend to have remained true to the uber cockroach of peptides: Tirzepatide..
Hope this helps..
 
Been on HRT for years recently added reata and klow 6 months now no issues
 
MrZardoz said:
I'm on HRT (and Tirz) myself, started by using the patch, and eventually after a few months, where I got tired of paying a little over $100 for just x4 patches, each time - I started with vial-based estradiol instead, and never looked back.
Along the way I've been using Tirz systematically - and tried Reta (which had no effect on me, unfortunately ) and never had any problems with HRT and Tirz, or any of the assorted other peptides I tried, along the way. I will say that - from what I've read - on Reddit - I'm working on only doing progesterone after about a year of HRT under my belt. (I'm only about 5 months in, so far) My 2 cents worth 🙂
Click to expand...

@MrZardoz, HOW do you figure the dosage from transdermal estradiol to injection-based estradiol? Do you use a compounding pharmacy for the estradiol? Is it weekly or daily? SO INTERESTING that this is an option! Thanks for any answers
🙂
 
SoCalGirl said:
@MrZardoz, HOW do you figure the dosage from transdermal estradiol to injection-based estradiol? Do you use a compounding pharmacy for the estradiol? Is it weekly or daily? SO INTERESTING that this is an option! Thanks for any answers
Click to expand...
Well, initially, I used Claude.ai as a source for answering my early questions- like 'in the following list of patches, can you rank them in order of 'serious' doses?' - which led to me choosing to buy 0.0375mg to begin with.

And paying a lot for the privilege.

I did that for a few months, then - fighting Claude every step of the way - I advanced to 0.1mg.

Then - as the speed of what I was doing seemed way too slow and I needed to advance to injections and the considerably cheaper cost of eeN (Estradiol enanthate) in vial form - (from $35 - $60 area) I slowly (using Claude again) got into finding crypto: how to move $ to the app/apps I chose, then converting it to BTC, then sending it to a wallet, then from there - got hand held through the steps to sending the crypto to the Vendor.

Re estradiol, I use Estradiol enanthate - which is a once weekly thing, and no, I've never used a compounding pharmacy for it (or the Tirz I get) My doctor is aware that I'm sourcing HRT/estradiol from 'other' methods, and only suggests blood works every few months. This is the DIY method. I'm aware there are other estradiol types - Undecylate, Valerate, and Cypionate - and each of these has a different frequency of injection to the one I use - I'm lazy, so once a week is easy to remember and achieve, alongside the Tirz as well.

(Claude has been described as 'the one single adult in the room' by a user, and its true. You often have to gently persuade him about what you want, and to help you achieve it. Utter honesty is the way forward with this AI.

But you should be able to get a list of standard doses, once you supply the name, the amount of the milligrams of the vial and any and all other info on the vial..Usually estradiol comes ready-made - with a carrier oil as part of the package...this, the right-sized syringe and following the instructions to keep the vial stored in a dark, cool-ish (not a fridge!) place - away from light. That should give you anything from 6-8 months, up to a couple of years of use, depending on the milligrams you've bought.

Hope this helps..

​

 
My wife has been on an HRT protocol for just about 2 yrs and we started Reta roughly 1 month into her HRT therapy. Its been a major change of life for her utilizing both along with protocols with Wolverine, NAD, and Mots-C. She is in the best condition she feels like in decades and shares her experience with anyone that asks or comments on her.
 
bonelifts said:
My wife has been on an HRT protocol for just about 2 yrs and we started Reta roughly 1 month into her HRT therapy. Its been a major change of life for her utilizing both along with protocols with Wolverine, NAD, and Mots-C. She is in the best condition she feels like in decades and shares her experience with anyone that asks or comments on her.
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I 'd love to be able to hear more about her experiences. I am so happy that it is all working for her.
 
Now back to the topic - Estradiol, Testosterone, and Progesterone are my HRTs, and I have been using them for 5 years or so - ZERO complications with the Reta or Tirz and Cagri weekly and daily KLOW or BPC and GHK. No problems. 😉

HRT is replacing what you lost, so if you were younger or had all your parts and pieces, you would have these in your body at "proper" levels. The HRT restores you to a bit under what you were at in your 40s, is my best guess. Although I wish it were at levels from my 20s!! So the HRT is providing you with what gets lost over the years. Zero interactions as far as I can tell.
MrZardoz said:
Well, initially, I used Claude.ai as a source for answering my early questions- like 'in the following list of patches, can you rank them in order of 'serious' doses?' - which led to me choosing to buy 0.0375mg to begin with.

And paying a lot for the privilege.

I did that for a few months, then - fighting Claude every step of the way - I advanced to 0.1mg.

Then - as the speed of what I was doing seemed way too slow and I needed to advance to injections and the considerably cheaper cost of eeN (Estradiol enanthate) in vial form - (from $35 - $60 area) I slowly (using Claude again) got into finding crypto: how to move $ to the app/apps I chose, then converting it to BTC, then sending it to a wallet, then from there - got hand held through the steps to sending the crypto to the Vendor.

Re estradiol, I use Estradiol enanthate - which is a once weekly thing, and no, I've never used a compounding pharmacy for it (or the Tirz I get) My doctor is aware that I'm sourcing HRT/estradiol from 'other' methods, and only suggests blood works every few months. This is the DIY method. I'm aware there are other estradiol types - Undecylate, Valerate, and Cypionate - and each of these has a different frequency of injection to the one I use - I'm lazy, so once a week is easy to remember and achieve, alongside the Tirz as well.

(Claude has been described as 'the one single adult in the room' by a user, and its true. You often have to gently persuade him about what you want, and to help you achieve it. Utter honesty is the way forward with this AI.

But you should be able to get a list of standard doses, once you supply the name, the amount of the milligrams of the vial and any and all other info on the vial..Usually estradiol comes ready-made - with a carrier oil as part of the package...this, the right-sized syringe and following the instructions to keep the vial stored in a dark, cool-ish (not a fridge!) place - away from light. That should give you anything from 6-8 months, up to a couple of years of use, depending on the milligrams you've bought.

Hope this helps..

​

Click to expand...
THANK YOU!! So much info in there. I'm a bit terrified of pinning the oil-based. Does it feel any different than regular pinning? I know, I am an idiot. Also, how do you figure out WHICH of the Estradiols to use? Thank you!
 
Is there anybody who takes their HRT via subQ shots instead of IM?
 
SoCalGirl said:
Now back to the topic - Estradiol, Testosterone, and Progesterone are my HRTs, and I have been using them for 5 years or so - ZERO complications with the Reta or Tirz and Cagri weekly and daily KLOW or BPC and GHK. No problems. 😉

HRT is replacing what you lost, so if you were younger or had all your parts and pieces, you would have these in your body at "proper" levels. The HRT restores you to a bit under what you were at in your 40s, is my best guess. Although I wish it were at levels from my 20s!! So the HRT is providing you with what gets lost over the years. Zero interactions as far as I can tell.

THANK YOU!! So much info in there. I'm a bit terrified of pinning the oil-based. Does it feel any different than regular pinning? I know, I am an idiot. Also, how do you figure out WHICH of the Estradiols to use? Thank you!
Click to expand...
Re feel any different, no, no different - just give yourself a count of say '10' to get all the oil/estradiol mix down the small insulin needle and into your body, before you withdraw the syringe. It shouldn't really hurt at all - it just might go a little slower than regular BAC for instance.
Re which one to use, as I said, I should know the frequency and methods behind each of the different estradiol's - but I don't know. I've asked one of my Claude's - 'Remote' Claude - to fill me in, here goes:

Here's a quick comparison:
Estradiol Enanthate (EEn)
  • Frequency: Once weekly
  • Half-life: ~4-5 days
  • Your current choice — stable levels, easy to remember, forgiving timing
Estradiol Cypionate (EC)
  • Frequency: Once weekly or every 10-14 days
  • Half-life: ~8 days
  • Slightly longer acting than EEn, very similar in practice, popular in DIY community
Estradiol Valerate (EV)
  • Frequency: Twice weekly
  • Half-life: ~3-5 days
  • More frequent injections needed for stable levels, less forgiving if you miss a dose

Estradiol Undecylate (EU)
  • Frequency: Every 2-4 weeks
  • Half-life: ~20+ days
  • Longest acting, least frequent — but level stability can be less consistent, harder to fine-tune dose
Summary:
  • Lazy/simple: EU (least frequent) or EEn/EC (weekly)
  • Stable levels: EEn or EC (weekly) generally considered best balance
  • Most control: EV (twice weekly, fine-tune easier but more injections)
Your EEn once weekly, said Remote Claude to me, is genuinely the sweet spot for most DIY users — stable, simple, predictable. 🙂
-I said thanks , and let him know I was cutting n pasting this info to the forum 🙂
 
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subQ is usually fine. Apparently intramuscular in the upper outer quadrant of your buttocks is supposed to be the best for dispersing it over a longer period of time, and that's what I do which seems to work for me.

I take 24mg estrogen undecylate every 2 weeks, alternating butt cheeks, though it's a bit difficult to do and scary with the big needle, so this isn't a recommendation. You'd want to be getting blood tests right before you inject, this is your "trough" as in the lowest amount of estrogen in your blood, and then you can compare that more easily to future tests.

Undecylate can last over a month, but it can take months to stabilize, so it's really annoying to find the right dose because you have to wait months every time you make a change to see how it effects your levels. Usually enthanate is easier, which you inject every week, because it's much easier to see how it affects your estrogen levels in your blood.
 
HistLady said:
I 'd love to be able to hear more about her experiences. I am so happy that it is all working for her.
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The wife is more than willing to share her experience and how its impacted her life. She just held a Zoom meeting with a group of my coworkers (female) as they just wanted to speak to someone like them before going to a provider.
 
HistLady said:
Hello all,
I am on my eleventh week on a low dose of Reta (currently 1.8 mg per week). After much consideration, I started HRT today (estradiol patch and my first dose of progesterone later tonight). I am supposed to dose Reta tomorrow morning. I want to know if anyone is on both HRT, Reta, or any other peptides like GHK-cu. What are your experiences? Any information welcome. Thanks!
Click to expand...
I'm on HRT & progesterone since last summer, started my peps in December and it's been all good. I'm doing a split dose of 2x/wk on Reta, AOD, Wolverine (will be replaced with KLOW), GHK-CU, and will be adding MOTS-C, NAD+, & DSIP to the cycle. Loving the result of weight loss (on the conservative side) that I've been struggling for ages.
 
That's such a lovely gesture on her part. I think that menopause needs so many more conversations. If she is ever willing to talk via Zoom, I would love to set that up.
 
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