i think this is probably exactly right
If not tirz+cagri, then what?
- Thread starter clayd
- Start date
i understand contrave has some risks, and should be taken under a physician's care and with labs, yes. just to be clear, i'm not suggesting that ANYONE self-treat with contrave or buy it on the grey market. but it is a medication that is used for weight management.
To get the pH down would be dependent on the pH of your cagri powder, your BAC water, the pH of what you're using to drop it, and the quantity of all three. Unfortunately, it's impossible for us to give you prescriptive guidance here. Ultimately, you need the pH of the final solution to be in range.
There's two things to keep in mind, though:
1) This will not destroy any existing fibrils or oligomers that might have been created pre-lyophilization, depending on how it was formulated. Fibrils tend to clump together, so a filter might catch some that have clumped together enough to be larger than the filter size, but individual fibrils are too small to be caught by a filter.
2) The patent filing shows different buffers used to drop the pH had different impact on the ability to prevent fibrils, even at 4.0. If you don't know what buffering agent was used originally and can't reference it against the patent, or how your acid impacts it, it's even harder to tell what the impact will be.
If I was going to use cagri I would drop the pH to 4.0 and opt for smaller vials so that I am not having it sit around reconstituted for extended periods of time. If you travel with reconstituted peptides at room temp, which seems to be fine for many of them, I would probably not do so with cagri.
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Sunflower
New_Member
It is marketed for weight management, but it is a synthesis of an NDRI “antidepressant” and naltrexone. I hope it doesn’t have any side effects for your wife, but I will add that when my binge eating was at its worst, Naltrexone and Wellbutrin didn’t touch the cravings or habits.
Tirz has done what 15+ meds couldn’t, and I do like the fact that with peptides you are meant to cycle without the serious withdrawals associated with antidepressants. Doctors know very little about how Wellbutrin works and can only go by qualitative data when measuring its effects. My psychiatrist did green light cycling low dose naltrexone, however, which is promising, as it also aids in resensitizing various receptors targeted by the peptides we use.
I think we have to ask ourselves if the juice is worth the squeeze. Maybe a 2-3 day struggle with a bit more hunger is okay and there is no problem to solve.
And I forgot to add.
7. Reassess caloric intake and exercise regiment.
For me, who knows which side is right on cagri. There is a lot of what ifs and subjectiveness to it. What I do know for myself, was that at 1mg, there were diminishing returns on curbing my hunger. I was always tired after using at doses .5mg and up, albeit it got better each week. For myself, the juice wasn't worth the squeeze. If I had to go back, I'd do the 7 aforementioned things.
this is helpful, thanks. so far i only did 4 weeks of 0.25mg and one week of 0.5mg. the fatigue has improved but it does seem like the appetite suppression is waning as well. i have heard the same elsewhere. i wonder if maybe it's just not very effective. like maybe this drug won't actually come to market.
agreed. Bupropion made me suicidal. It was incredibly scary. Contrave also didn't work for me at all so I was suicidal and still fat and it was basically the worst of both worlds. I would never recommend it lightly with GLP1s available now.
Bupropion is great when it works, but when it doesn't it's very, very scary.
I was put on it years ago and nearly ended up hospitalized; I take it again now in conjunction with a mood stabilizer. It can be used for a few things- ADHD, depression, weight loss, smoking cessation. But it's a rough one to play with once it's time to come off.
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i clearly hit on a touchy topic. i'm very sorry for people's bad experience on contrave or wellbutrin. i only meant to suggest that there are non-glp1 weight loss meds available that might be useful as a stack. but i agree that contrave/wellbutrin is not to be trifled with, and i'm very sorry for the way it affected some of you.
Sorry, I didn't mean to derail; it's just not something to go on casually. You need a dr to supervise a taper coming off, whereas a glp-1 you can stop cold turkey. We're all here, so I doubt anyone who needs this information would see it on this forum anyway.
no worries at all, i'm glad people shared their experience here so that anyone running across this thread can be informed.
MrsRoper_1977
Research Enthusiast
It’s been a few weeks since you posted this. How’s Survo working for you now?SURVO
I was dosing every 3 days(alternating meds) of Tirz + cag & reta + cag.
Dropped the tirz and replaced with Survo. Works great.
keangkong
Research Enthusiast
Take it twice per week.
