IGF-1 LR3 - not seeing much talk here

[latviantower]

I’ve been doing a lot of reading, and I see more than a few recommendations of people saying skip the GLP1 and go straight to HGH. If the point of HGH is the stimulate production of IGF-I, I’m a little surprised that I don’t see more recommendations of proceeding straight to using IGF-I and skipping that intermediate HGH step. That being said, I also haven’t seen any research protocols on this forum for IGF-I. My reading on other research sites has suggested 50-100 mcg daily, 4-6 weeks/4-6 weeks off.

Any feedback? AndyPanda, you seem to be forthcoming with the HGH recommendation- do you have thoughts here? Does anyone else have experiences to share?

Thanks.

 

[Calm Logic]

I’ve been doing a lot of reading, and I see more than a few recommendations of people saying skip the GLP1 and go straight to HGH.

No such recommendations here to skip GLPs, at least for losing weight.

There isn't that much talk at Meso about LR3. There is some, but nothing compared to HGH.

Compared to HGH, LR3 is not as well researched or understood, including regarding side effects. HGH is at least FDA approved for some things.

 

[Calm Logic]

For better or worse, LR3 also has a longer half-life than HGH. My new favorite single-vial reseller, Grey Axis ("a chemical supplier"), has LR3 on their website. Amino Annex also sells it by the vial.

But the lack of research articles on LR3 is still very concerning. There are no human studies. There is a positive article on the Meso site, but it mentions bilateral injection for the muscle group just trained:

https://thinksteroids.com/steroid-profiles/igf-1/

And I just read that low-strength acetic acid is needed for recon:

The Most Advanced Peptide Recovery Protocol

Endless Evolution Physiological Amplification Method Physiological Tissue Regeneration via Peptides and the Systematic Amplification of Cellular Process & Organization, Receptor Signaling & Modulation, and related Physiological processes. Before we dive into the jaw-dropping case studies below...

www.chrisduffin.com

LR3 needs to be reconstituted with .05% (NOT .5%) acetic acid solution versus Bacteriostatic Water that is more readily available. Because it is reconstituted in an acid, after drawing your dose into your needle for administration you should backload another 15+ units of Bacteriostatic Water into the syringe to reduce the PH. The acetic acid is needed while in the vial so that it doesn’t degrade but adding water into the syringe right before administration will be better than injecting it as an acid. This will also help it disperse into the tissue further.

The author of that blog post says he rather just take GHRP instead, due to the complexity of LR3 recon/administration.

On the positive side, LR3 seems less illicit than HGH. Though LR3 is an unapproved drug, it is not specifically mentioned in federal regulations like HGH.

Similar info on Reddit about recon:

https://www.reddit.com/r/Peptides/comments/blc83a/comment/en86zop

View: https://www.reddit.com/r/Peptides/comments/blc83a/comment/en86zop/?utm_source=share&utm_medium=web3x&utm_name=web3xcss&utm_term=1&utm_content=share_button

 

[RocketGotRobbed]

I knoow several guys on blast whoo have replaced HGH with LR3. They swear by it. I am still using HGH myself. It is what I know and fully understand. I may give LR3 ago next cycle.

 

[Calm Logic]

Do you know what doses they are using for LR3? And are they injecting it subq like HGH?

The doses seem all over the place. The Meso article mentions 100 mcg, but I saw one guy was using up to 500 mcg per day. On the low end:

The Most Advanced Peptide Recovery Protocol

Endless Evolution Physiological Amplification Method Physiological Tissue Regeneration via Peptides and the Systematic Amplification of Cellular Process & Organization, Receptor Signaling & Modulation, and related Physiological processes. Before we dive into the jaw-dropping case studies below...

www.chrisduffin.com

Some examples:

25mcg x 2 day Every Other Day EOD for 4-6 weeks
25mcg Every 3rd Day E3D for 12+ weeks

It should be noted that the 25mcg dose reduces spillover, which is not desirable as the greatest concentration of IGF receptors are in the gut.

 

[AndyPanda]

I’ve been doing a lot of reading, and I see more than a few recommendations of people saying skip the GLP1 and go straight to HGH. If the point of HGH is the stimulate production of IGF-I, I’m a little surprised that I don’t see more recommendations of proceeding straight to using IGF-I and skipping that intermediate HGH step. That being said, I also haven’t seen any research protocols on this forum for IGF-I. My reading on other research sites has suggested 50-100 mcg daily, 4-6 weeks/4-6 weeks off.

Any feedback? AndyPanda, you seem to be forthcoming with the HGH recommendation- do you have thoughts here? Does anyone else have experiences to share?

Thanks.

I don’t know of anything better for weight than GLPs. I think HGH is more to the point than any of the secretagogues and the niche peptides like AOD, 5-Amino. I think it’s the best for anti-aging as well but if you are under 40 you probably produce enough GH on your own. The only peptides I have faith in are GLPs, Glutathione and AICAR. I’ve tried more at this point than I haven’t but everyone is different.

 

[Calm Logic]

I have no complaints about HGH either, especially given its synergy with AAS.

HGH just seems fragile compared to GLPs and other peptides. Like fragile enough that some on Meso may rightly be saying that filtering it may cause unnecessary mechanical stress, leading to aggregation. I don't usually filter anymore anyway.

 

[RocketGotRobbed]

I asked the couple of dudes I know. they both said 50mcg IM into the muscle group they are training. I'll pass.

 

[AndyPanda]

I asked the couple of dudes I know. they both said 50mcg IM into the muscle group they are training. I'll pass.

I’m no expert, but that sounds off to me.

2-4 IU per day subcutaneous with a maximum dosage of 6 IU used by extreme bodybuilders.

HGH cycles are broad and can be anywhere from 6 to 24 weeks, with 16 weeks being the average duration for a bodybuilding cycle.

 

[latviantower]

I’m no expert, but that sounds off to me.

2-4 IU per day subcutaneous with a maximum dosage of 6 IU used by extreme bodybuilders.

HGH cycles are broad and can be anywhere from 6 to 24 weeks, with 16 weeks being the average duration for a bodybuilding cycle.

I think he was referring to IGF1, not HGH. 50 mcg does seem high - most of what I read was more like 20 bilaterally - 20 in each bicep post workout for example. But pro bodybuilders probably go higher.

 

[AndyPanda]

I think he was referring to IGF1, not HGH. 50 mcg does seem high - most of what I read was more like 20 bilaterally - 20 in each bicep post workout for example. But pro bodybuilders probably go higher.

Ah, I see. My bad.