I'm not impressed.

There’s a table floating around on this site and elsewhere. Looking for it now.
 

Anyone trial >12 mg Reta or stalled on high dose reta?

Hey all, For some background, I've been on GLPs for >1.5 yrs. Started on Tirz, maxed out and stalled at 15mg. Switched to reta about 3 months ago and am currently at Reta 10mg. On my switch I regained about 10 lbs but reduced 3 of those lbs on reta so far. So net -7 lbs. Just wondering how...
glp1forum.com glp1forum.com
 
Olbartmore77 said:
Can anyone recommend a Reta starting dose coming from 15mg zepbound?
Click to expand...
There are no official dose equivalents for the GLP's.
The answer depends a bit on what side effects you got from tirzepatide either at your current dose or as you increased doses. Obviously the more side effects the lower swapover dose. If you have cardiovascular disease maybe go lower as well due to the heart rate increase being larger on reta. And it depends on general health and other illnesses, especially diabetes.
In terms of straight equivalents it is probably about 8-10mg. Reta has higher glp-1 agonism and less gip agonism so can cause more gi side effects than tirz.
To be safeish I would go with 6-8mg, but there is always a chance of more side effects than expected from different GLP's, so if being a bit pukey for a week might interfere with work or something else go lower rather than higher.
 
lessthanhalf said:
There are no official dose equivalents for the GLP's.
The answer depends a bit on what side effects you got from tirzepatide either at your current dose or as you increased doses. Obviously the more side effects the lower swapover dose. If you have cardiovascular disease maybe go lower as well due to the heart rate increase being larger on reta. And it depends on general health and other illnesses, especially diabetes.
In terms of straight equivalents it is probably about 8-10mg. Reta has higher glp-1 agonism and less gip agonism so can cause more gi side effects than tirz.
To be safeish I would go with 6-8mg, but there is always a chance of more side effects than expected from different GLP's, so if being a bit pukey for a week might interfere with work or something else go lower rather than higher.
Click to expand...
I guess, put all this advice not based on science in a hat shake it up and draw one and help for the best?
 
Retazempic said:
All that science is occurring in this site
Click to expand...
breaking bad amc GIF
 
tubby said:
I mean that's exactly what the Reta-zempic guy would try to tell you. You're going to need to hit up Retazepatide if you want a straight answer to your question, I'm afraid.
Click to expand...
When you have no degree or specialty in these non science base options on changing from one glp1 to another, means jack shit. So am I supposed to believe you are the expert in any of these protocals
Canadian Lol GIF
The Office Lol GIF
?
 
lessthanhalf said:
There are no official dose equivalents for the GLP's.
The answer depends a bit on what side effects you got from tirzepatide either at your current dose or as you increased doses. Obviously the more side effects the lower swapover dose. If you have cardiovascular disease maybe go lower as well due to the heart rate increase being larger on reta. And it depends on general health and other illnesses, especially diabetes.
In terms of straight equivalents it is probably about 8-10mg. Reta has higher glp-1 agonism and less gip agonism so can cause more gi side effects than tirz.
To be safeish I would go with 6-8mg, but there is always a chance of more side effects than expected from different GLP's, so if being a bit pukey for a week might interfere with work or something else go lower rather than higher.
Click to expand...
Hi, I saw on youtube and read some post on sites, they mentioned Reta has more GIP and less GLP, while Tirz is the opposite.

Just wanting to clarify. Thanks.
 
CNCCurrency said:
Whose?
Click to expand...
I do not claim to be a genuine expert , but I do have a related degree, and have read pretty much every glp-1 related paper I have found over several years, spending at least a few hundred hours on research, so I think my statement is entirely reasonable. My guesses and estimates are based on a reasonably thorough understanding of the science.
 
thatkatmat said:
Yes, I understand that. that's why I waited until week 3 as I was on a preclinical dose to get the feel of it and made the decision to move up to a more typical starting dose of .25. I appreciate the input.
Click to expand...

Unimpressed Shania Twain GIF
 
Fishcakes88 said:
Hi, I saw on youtube and read some post on sites, they mentioned Reta has more GIP and less GLP, while Tirz is the opposite.

Just wanting to clarify. Thanks.
Click to expand...
I have done this about 3 times now, but.
All the receptors activation contribute to the appetite supressing and weight loss effects of the different glp's. GLP-1, GIP and Glucagon - all agonists
The behaviour of these drugs at glp-1 receptors is complex. 99% of the drug is bound to albumin to start with which influences how much is available at the receptors. Most of the ki or binding affinity numbers online are not necessarily correct, and AI responses are not either, and most of the info is buried in early studies usually under the drug development names which are different. I spent a fair bit of time trying to work this out after seeing different and contradictory information about the activity of different GLP's on the receptors, so I think my information is correct but cannot be certain. I did dig through quite a few papers to work this out.
The effect of the drugs after binding to the receptors is via secondary intracellular messengers, for glp-1 beta-arrestin and cAMP it is these that determine the effects. Tirzepatide has intentionally designed biased agonism on glp-1 affecting beta-arrestin less than natural glp or semaglutide or retatrutide. Beta arrestin once activated causes the glp-1 receptors to be taken inside the cell so they can no longer have an effect. This is how a dosage adjusted amount of tirzepatide can have a stronger effect on glp-1 than semaglutide, despite lower affinity. And it also leads to less nausea although I am not sure by what mechanism. Glp-1 agonism causes nausea and malaise and food aversion responses.
Gip agonism is not as complicated, but from what I could determine tirzepatide has stronger effects than retatrutide. Gip agonism counteracts nausea and malaise and food aversion due to glp-1 responses via brain receptors. Tirzepatides stronger gip agonism is mainly why it causes less gi side effects.
so in terms of glp-1 effects on weight loss it is probably tirzepatide>semaglutide>retatrutide ( assuming standard maximum doses )
Despite this semaglutide and retatrutide have stronger binding to glp-1 than tirzepatide, but the total effect after the biased signalling is taken into account changes this.
In terms of gi adverse effects ( glp-1 adverse effects ) semaglutide>retatrutide>tirzepatide
retatrutide has better weight loss due to the added glucagon agonism, but is more likely to increase heart rate, and probably more likely to cause skin sensory symptoms. I have attempted to work this out without sucess. The high dose semaglutide study showed high rates of skin sensory symotoms, but were rare in the low dose studies, so it has to be via glp-1, but does not explain why it is more common from reta.
Tirzepatide has less gi side effects than semaglutide and retatrutide mainly due to the stronger gip agonism counteracting the effects of glp agonism on nausea.
Not exactly crystal clear explanation, but I think this view of the receptor effects fits with the different side effect profiles of the different glp's fairly well.
 
lessthanhalf said:
I have done this about 3 times now, but.
All the receptors activation contribute to the appetite supressing and weight loss effects of the different glp's. GLP-1, GIP and Glucagon - all agonists
The behaviour of these drugs at glp-1 receptors is complex. 99% of the drug is bound to albumin to start with which influences how much is available at the receptors. Most of the ki or binding affinity numbers online are not necessarily correct, and AI responses are not either, and most of the info is buried in early studies usually under the drug development names which are different. I spent a fair bit of time trying to work this out after seeing different and contradictory information about the activity of different GLP's on the receptors, so I think my information is correct but cannot be certain. I did dig through quite a few papers to work this out.
The effect of the drugs after binding to the receptors is via secondary intracellular messengers, for glp-1 beta-arrestin and cAMP it is these that determine the effects. Tirzepatide has intentionally designed biased agonism on glp-1 affecting beta-arrestin less than natural glp or semaglutide or retatrutide. Beta arrestin once activated causes the glp-1 receptors to be taken inside the cell so they can no longer have an effect. This is how a dosage adjusted amount of tirzepatide can have a stronger effect on glp-1 than semaglutide, despite lower affinity. And it also leads to less nausea although I am not sure by what mechanism. Glp-1 agonism causes nausea and malaise and food aversion responses.
Gip agonism is not as complicated, but from what I could determine tirzepatide has stronger effects than retatrutide. Gip agonism counteracts nausea and malaise and food aversion due to glp-1 responses via brain receptors. Tirzepatides stronger gip agonism is mainly why it causes less gi side effects.
so in terms of glp-1 effects on weight loss it is probably tirzepatide>semaglutide>retatrutide ( assuming standard maximum doses )
Despite this semaglutide and retatrutide have stronger binding to glp-1 than tirzepatide, but the total effect after the biased signalling is taken into account changes this.
In terms of gi adverse effects ( glp-1 adverse effects ) semaglutide>retatrutide>tirzepatide
retatrutide has better weight loss due to the added glucagon agonism, but is more likely to increase heart rate, and probably more likely to cause skin sensory symptoms. I have attempted to work this out without sucess. The high dose semaglutide study showed high rates of skin sensory symotoms, but were rare in the low dose studies, so it has to be via glp-1, but does not explain why it is more common from reta.
Tirzepatide has less gi side effects than semaglutide and retatrutide mainly due to the stronger gip agonism counteracting the effects of glp agonism on nausea.
Not exactly crystal clear explanation, but I think this view of the receptor effects fits with the different side effect profiles of the different glp's fairly well.
Click to expand...
Thank You for your explanation, I do appreciate the reply.
 
lessthanhalf said:
I do not claim to be a genuine expert , but I do have a related degree, and have read pretty much every glp-1 related paper I have found over several years, spending at least a few hundred hours on research, so I think my statement is entirely reasonable. My guesses and estimates are based on a reasonably thorough understanding of the science.
Click to expand...
I suspect they're just teasing you for referring to "the science," which has become a very common form of the "appeal to authority" logical fallacy in the current decade. I'm not accusing you of doing this, but it's become quite fashionable for a random reporter or internet influencer to invoke "the science" as their means of spitting out an answer without being capable of actually justifying that answer. It's kind of the modern version of what in the 1960s would have been "because my dad says it's that way."

I know that's not what you meant when you said it (and you generally seem to be informed on the topics you discuss). I'm just telling you how it comes across to most people who hear "the science."
 
lessthanhalf said:
I do not claim to be a genuine expert , but I do have a related degree, and have read pretty much every glp-1 related paper I have found over several years, spending at least a few hundred hours on research, so I think my statement is entirely reasonable. My guesses and estimates are based on a reasonably thorough understanding of the science.
Click to expand...
Interested Glasses GIF by eppendorf
scientist women in stem GIF by Diversify Science Gifs
 
lessthanhalf said:
There are no official dose equivalents for the GLP's.
The answer depends a bit on what side effects you got from tirzepatide either at your current dose or as you increased doses. Obviously the more side effects the lower swapover dose. If you have cardiovascular disease maybe go lower as well due to the heart rate increase being larger on reta. And it depends on general health and other illnesses, especially diabetes.
In terms of straight equivalents it is probably about 8-10mg. Reta has higher glp-1 agonism and less gip agonism so can cause more gi side effects than tirz.
To be safeish I would go with 6-8mg, but there is always a chance of more side effects than expected from different GLP's, so if being a bit pukey for a week might interfere with work or something else go lower rather than higher.
Click to expand...
I was very fortunate to have zero side effects throughout the course titration with Reta. I’m sure my luck has to run out and when I start Reta I’ll be sure to keep your advice in mind. Thank you for the reply.
 
BadLouie said:
Like many of you, I have a food problem. I'm hungry, I'm always hungry. So, what I specifically need is something to reduce the food noise.

I recently started my research on Cagri. I've read many stories about how strong it was for food noise suppression. My experience has not been what I expected.

Background.

I've been taking GLP medication for 2 years not. Currently taking 15mg Tirz weekly. I gained tolerance quite quickly and have really seen no kind of notable results after 10mg weekly. Early on it had great results, now I feel it VERY little. I briefly tried adding Sema to my regimen specifically for the food noise suppression. I had nearly no response at all, I was completely convinced I had fake product because a 2.5 had literally no effect on me even with the Tirz. My GF tried it and 6 months later she is down probably 60lbs and thinks its a miracle drug, so yeah its real and works lol. I stopped after a month.

I then tried a 90 day break. I def noticed i was absolutely starving after a couple weeks off but it subsided after a bit. I then jumped back on the tirz excited to get back after my tolerance break. Unfortunately, by the 3rd week my tolerance had come back. I was back to having no noticeable effect.

Then I tried RETA. Wow what a waste of time and money. I quickly reached 12mg weekly and I felt nothing at all. After going through several bottles, I just put it back on the shelf.

Now on to Cagri.
Week 1- .25 mg dosage with the 15mg tirz. Very mild stomach discomfort.
Week 2- .5 mg with 15mg tirz. Still nothing really of note.
Week 3- 1mg with 15 tirz. Now we got something... Felt similar to Tirz working, def helped for about 5 days.
Week 4- 1mg with 15 tirz, Maybe 15 minutes of feeling like i need to burp.
Week 5- 1mg with 15 tirz, not even a grumble.
Week 6- I think im going to step up again, try a 1.5

Is it common to have such a tolerance for these medications? Everyone I know that uses these is having much more of a response than I am. My gf is on like .5mg sema and having great results, Mother 7.5 tirz and works wonderfully. I'm feeling a bit lost here. I think my next experiment will be with just larger doses of Tirz since it's the only one I've had good results with. I've seen some posts about people exceeding 20mg. That seems to be the path.

Have you tried Cagri and been unimpressed with the hype?
Do you know of any cheat codes i dont?
What could be unique with me that im not responding as well as so many others?
Click to expand...


Similar to you, i became 'used' to Reta.
Given that, ive been on it over 12 months and im still only on 4mg/week

But the last 4 weeks ive actually incorporated 1 mg of Cag and its fantastic.
That mix has me feeling satiety for 6-7 days MOST weeks. (depending on how ocupied i am)

Can we get an update though? I went through and noticed you havent replied to anyone.
Im curious 🙂
 
If I can weigh in, I’ve just incorporated 1 mg/week of Cagrilintide and it’s working really well. Currently on 4 mg/week Retatrutide as well. Great appetite suppression for me and I’ve dropped two pounds the last week.

Also saw one inch less around the waist (maybe more) which seems insane to me for just one week. Fat around the waist/internal organs is also the main thing I’m targeting right now more than general weight loss.
 
I am currently on 1.6 mg of reta every three days. I tried 0.2 mg of cagri and it apsolutely destroyed my apetite. Still managed to eat 200g of protein but it was very difficult. I think il pause the cagri for now and up my reta. Maybe introduce cagri again when my reta dose is higher
 
days_before said:
I am currently on 1.6 mg of reta every three days. I tried 0.2 mg of cagri and it apsolutely destroyed my apetite. Still managed to eat 200g of protein but it was very difficult. I think il pause the cagri for now and up my reta. Maybe introduce cagri again when my reta dose is higher
Click to expand...
With a 6 day half life why in the world would you pin every 3 days?
 
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