I'm not impressed.

[BadLouie]

Like many of you, I have a food problem. I'm hungry, I'm always hungry. So, what I specifically need is something to reduce the food noise.

I recently started my research on Cagri. I've read many stories about how strong it was for food noise suppression. My experience has not been what I expected.

Background.

I've been taking GLP medication for 2 years not. Currently taking 15mg Tirz weekly. I gained tolerance quite quickly and have really seen no kind of notable results after 10mg weekly. Early on it had great results, now I feel it VERY little. I briefly tried adding Sema to my regimen specifically for the food noise suppression. I had nearly no response at all, I was completely convinced I had fake product because a 2.5 had literally no effect on me even with the Tirz. My GF tried it and 6 months later she is down probably 60lbs and thinks its a miracle drug, so yeah its real and works lol. I stopped after a month.

I then tried a 90 day break. I def noticed i was absolutely starving after a couple weeks off but it subsided after a bit. I then jumped back on the tirz excited to get back after my tolerance break. Unfortunately, by the 3rd week my tolerance had come back. I was back to having no noticeable effect.

Then I tried RETA. Wow what a waste of time and money. I quickly reached 12mg weekly and I felt nothing at all. After going through several bottles, I just put it back on the shelf.

Now on to Cagri.
Week 1- .25 mg dosage with the 15mg tirz. Very mild stomach discomfort.
Week 2- .5 mg with 15mg tirz. Still nothing really of note.
Week 3- 1mg with 15 tirz. Now we got something... Felt similar to Tirz working, def helped for about 5 days.
Week 4- 1mg with 15 tirz, Maybe 15 minutes of feeling like i need to burp.
Week 5- 1mg with 15 tirz, not even a grumble.
Week 6- I think im going to step up again, try a 1.5

Is it common to have such a tolerance for these medications? Everyone I know that uses these is having much more of a response than I am. My gf is on like .5mg sema and having great results, Mother 7.5 tirz and works wonderfully. I'm feeling a bit lost here. I think my next experiment will be with just larger doses of Tirz since it's the only one I've had good results with. I've seen some posts about people exceeding 20mg. That seems to be the path.

Have you tried Cagri and been unimpressed with the hype?
Do you know of any cheat codes i dont?
What could be unique with me that im not responding as well as so many others?

 

[zpped]

Low responders are a thing. There are trials in the works for much higher doses. I know of people taking 30mg of tirz or 20-25mg of reta.

I know one person who was on 12mg of reta for 6 months and their cholesterol was greatly improving but they weren't loosing weight. She is now on 20mg of reta and losing weight.

If you're not having side effects and you don't titrate too fast, it seems to be pretty safe to go to much higher doses if you need it.

 

[Jellybelly54]

What about trying orforglipron?

 

[zpped]

What about trying orforglipron?

In general orfo is less effective than the others. Now that isn't to say they individually won't have better results because it's a very different pathway.

 

[thatkatmat]

I'm currently doing 5mg Tirz and didn't want to up my dose after just 2 months..Food noise was hitting me on day 5, I decided to go to every 5 days (maybe you want to try that?) it worked for me a bit too much, so, I went back to 7 days and added Cagri.
I started very low (just 125mcg's) Actually just started yesterday and wow..I felt very full after just 6 or 7 hours after pinning. I'm at day 2 and I just had a light breakfast and wow, full again...Glass of water? Full! so...If Tirz and Cagri isn't working for you, like I said, maybe use the GLP pllotter https://glp1plotter.com/ and move to a 5 or 6 day schedule?
Good luck with your research!

 

[CNCCurrency]

Like many of you, I have a food problem. I'm hungry, I'm always hungry. So, what I specifically need is something to reduce the food noise.

I recently started my research on Cagri. I've read many stories about how strong it was for food noise suppression. My experience has not been what I expected.

Background.

I've been taking GLP medication for 2 years not. Currently taking 15mg Tirz weekly. I gained tolerance quite quickly and have really seen no kind of notable results after 10mg weekly. Early on it had great results, now I feel it VERY little. I briefly tried adding Sema to my regimen specifically for the food noise suppression. I had nearly no response at all, I was completely convinced I had fake product because a 2.5 had literally no effect on me even with the Tirz. My GF tried it and 6 months later she is down probably 60lbs and thinks its a miracle drug, so yeah its real and works lol. I stopped after a month.

I then tried a 90 day break. I def noticed i was absolutely starving after a couple weeks off but it subsided after a bit. I then jumped back on the tirz excited to get back after my tolerance break. Unfortunately, by the 3rd week my tolerance had come back. I was back to having no noticeable effect.

Then I tried RETA. Wow what a waste of time and money. I quickly reached 12mg weekly and I felt nothing at all. After going through several bottles, I just put it back on the shelf.

Now on to Cagri.
Week 1- .25 mg dosage with the 15mg tirz. Very mild stomach discomfort.
Week 2- .5 mg with 15mg tirz. Still nothing really of note.
Week 3- 1mg with 15 tirz. Now we got something... Felt similar to Tirz working, def helped for about 5 days.
Week 4- 1mg with 15 tirz, Maybe 15 minutes of feeling like i need to burp.
Week 5- 1mg with 15 tirz, not even a grumble.
Week 6- I think im going to step up again, try a 1.5

Is it common to have such a tolerance for these medications? Everyone I know that uses these is having much more of a response than I am. My gf is on like .5mg sema and having great results, Mother 7.5 tirz and works wonderfully. I'm feeling a bit lost here. I think my next experiment will be with just larger doses of Tirz since it's the only one I've had good results with. I've seen some posts about people exceeding 20mg. That seems to be the path.

Have you tried Cagri and been unimpressed with the hype?
Do you know of any cheat codes i dont?
What could be unique with me that im not responding as well as so many others?

I think you can do 4.5mg a week on cagri

 

[Cdub100]

I took 1mg Saturday. It took a day, and Holy hell has it suppressed my appetite to the point I feel full all day and can barely eat. It's almost too much

 

[tubby]

I notice much of the OP seems to be assessing results based on how the OP "feels" when using a certain compound. To be sure, OP, were you also tracking your weight during these periods and verified that no changes were occurring there? If you're not tracking weight changes and just going off of perceived appetite, that's probably not going to be very objective. You're also going to be hyperfixated on appetite and food noise, if those are the variable you're tracking the most closely, which may cause them to seem greater simply due to your fixation on them.

Assuming weight loss has been stalled this entire time, as others have noted, there's massive variability in results from person to person. I don't have a link to it handy, but if you can hunt down the phase 2 data supplement for retatrutide, the variability is insane. There was one person in the placebo group who lost over 20% of their body weight during the trial. Meanwhile, there were several people on 4mg/week who actually gained weight during the trial!

An interesting thought problem (that would be impossible to study, short of developing portals to other dimensions) is pondering how the result for a given person would vary, depending on if they were on different dosage levels of a given med. For example if I ran a 48 week trial on you at 2mg, hit the rewind button on time, and then ran the same 48 week trial on you at 4mg, 8mg, etc. how would your results vary? The closest we can come to estimating what that result might be is to look at the results achieved by the top 5% and bottom 5% losers for each dosage level. These can be eyeballed from the "waterfall" plots. In the case of retatrutide, I'm seeing:

Worst 5%:
Placebo: ~+5%
1mg: ~-1%
4mg: ~-3%
8mg: ~-6%
12mg: ~-6%

Best 5%:
Placebo: ~-14%
1mg: ~-30%
4mg: ~-38%
8mg: ~-40%
12mg: ~-42%

And that's for retatrutide, arguably the "best" that's currently available. Sadly, for ~5% of people, even at the highest dosages, they're going to be quite underwhelmed by their results.

 

[Peptidesearch]

It's amazing how different we all are, Tirz. immediately killed my appetite at even the lowest doses. Unfortunately it gave me severe Gerd and tons of other side effects so I quit at 7.5mg.
I'm much happier on Reta, very mild so far except for some fatigue.

What about adding something like Contrave (naltrexone/bupropion) to deal with appetite suppression separately?

 

[Retazempic]

Like many of you, I have a food problem. I'm hungry, I'm always hungry. So, what I specifically need is something to reduce the food noise.

I recently started my research on Cagri. I've read many stories about how strong it was for food noise suppression. My experience has not been what I expected.

Background.

I've been taking GLP medication for 2 years not. Currently taking 15mg Tirz weekly. I gained tolerance quite quickly and have really seen no kind of notable results after 10mg weekly. Early on it had great results, now I feel it VERY little. I briefly tried adding Sema to my regimen specifically for the food noise suppression. I had nearly no response at all, I was completely convinced I had fake product because a 2.5 had literally no effect on me even with the Tirz. My GF tried it and 6 months later she is down probably 60lbs and thinks its a miracle drug, so yeah its real and works lol. I stopped after a month.

I then tried a 90 day break. I def noticed i was absolutely starving after a couple weeks off but it subsided after a bit. I then jumped back on the tirz excited to get back after my tolerance break. Unfortunately, by the 3rd week my tolerance had come back. I was back to having no noticeable effect.

Then I tried RETA. Wow what a waste of time and money. I quickly reached 12mg weekly and I felt nothing at all. After going through several bottles, I just put it back on the shelf.

Now on to Cagri.
Week 1- .25 mg dosage with the 15mg tirz. Very mild stomach discomfort.
Week 2- .5 mg with 15mg tirz. Still nothing really of note.
Week 3- 1mg with 15 tirz. Now we got something... Felt similar to Tirz working, def helped for about 5 days.
Week 4- 1mg with 15 tirz, Maybe 15 minutes of feeling like i need to burp.
Week 5- 1mg with 15 tirz, not even a grumble.
Week 6- I think im going to step up again, try a 1.5

Is it common to have such a tolerance for these medications? Everyone I know that uses these is having much more of a response than I am. My gf is on like .5mg sema and having great results, Mother 7.5 tirz and works wonderfully. I'm feeling a bit lost here. I think my next experiment will be with just larger doses of Tirz since it's the only one I've had good results with. I've seen some posts about people exceeding 20mg. That seems to be the path.

Have you tried Cagri and been unimpressed with the hype?
Do you know of any cheat codes i dont?
What could be unique with me that im not responding as well as so many others?

Although it seems to be very rare, something for low responders to consider is the possibility that they might have developed some level of antibodies to their peptide.

A study affiliated with EL noted that one study participant developed “anti-drug antibodies” to Reta.

To be clear, I do not know exactly what this means scientifically. It just stuck out to me.

I have attached the paper. The sentence is on the bottom of p. 1241 (Don’t worry - that’s the page number in the journal. It’s on page 9 of the attached pdf, which is only 24 pages.)

 

[tubby]

Although it seems to be very rare, something for low responders to consider is the possibility that they might have developed some level of antibodies to their peptide.

A study affiliated with EL noted that one study participant developed “anti-drug antibodies” to Reta.

To be clear, I do not know exactly what this means scientifically. It just stuck out to me.

I have attached the paper. The sentence is on the bottom of p. 1241 (Don’t worry - that’s the page number in the journal. It’s on page 9 of the attached pdf, which is only 24 pages.)

Not that uncommon, really. See Table 3 in the phase 2 trial here:

https://www.nejm.org/doi/full/10.1056/NEJMoa2301972#t3

Looks like 9% of study participants developed anti-drug antibodies. Although I'm not sure I understand the full significance and meaning of that being detected. Most surprisingly, one of those people was even in the placebo group! Not sure if that's a fluke, there's some deeper meaning I'm not understanding, or if one of the "placebo" people secretly took gray market reta during the trial. I guess that could explain how that one person in the placebo group lost 20% of their body weight! Or maybe the researchers screwed up and mixed up study participants. I'd like to believe they would have controls in place such that it couldn't happen, though.