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BadLouie

BadLouie

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Like many of you, I have a food problem. I'm hungry, I'm always hungry. So, what I specifically need is something to reduce the food noise.

I recently started my research on Cagri. I've read many stories about how strong it was for food noise suppression. My experience has not been what I expected.

Background.

I've been taking GLP medication for 2 years not. Currently taking 15mg Tirz weekly. I gained tolerance quite quickly and have really seen no kind of notable results after 10mg weekly. Early on it had great results, now I feel it VERY little. I briefly tried adding Sema to my regimen specifically for the food noise suppression. I had nearly no response at all, I was completely convinced I had fake product because a 2.5 had literally no effect on me even with the Tirz. My GF tried it and 6 months later she is down probably 60lbs and thinks its a miracle drug, so yeah its real and works lol. I stopped after a month.

I then tried a 90 day break. I def noticed i was absolutely starving after a couple weeks off but it subsided after a bit. I then jumped back on the tirz excited to get back after my tolerance break. Unfortunately, by the 3rd week my tolerance had come back. I was back to having no noticeable effect.

Then I tried RETA. Wow what a waste of time and money. I quickly reached 12mg weekly and I felt nothing at all. After going through several bottles, I just put it back on the shelf.

Now on to Cagri.
Week 1- .25 mg dosage with the 15mg tirz. Very mild stomach discomfort.
Week 2- .5 mg with 15mg tirz. Still nothing really of note.
Week 3- 1mg with 15 tirz. Now we got something... Felt similar to Tirz working, def helped for about 5 days.
Week 4- 1mg with 15 tirz, Maybe 15 minutes of feeling like i need to burp.
Week 5- 1mg with 15 tirz, not even a grumble.
Week 6- I think im going to step up again, try a 1.5

Is it common to have such a tolerance for these medications? Everyone I know that uses these is having much more of a response than I am. My gf is on like .5mg sema and having great results, Mother 7.5 tirz and works wonderfully. I'm feeling a bit lost here. I think my next experiment will be with just larger doses of Tirz since it's the only one I've had good results with. I've seen some posts about people exceeding 20mg. That seems to be the path.

Have you tried Cagri and been unimpressed with the hype?
Do you know of any cheat codes i dont?
What could be unique with me that im not responding as well as so many others?
 
Low responders are a thing. There are trials in the works for much higher doses. I know of people taking 30mg of tirz or 20-25mg of reta.

I know one person who was on 12mg of reta for 6 months and their cholesterol was greatly improving but they weren't loosing weight. She is now on 20mg of reta and losing weight.

If you're not having side effects and you don't titrate too fast, it seems to be pretty safe to go to much higher doses if you need it.
 
I'm currently doing 5mg Tirz and didn't want to up my dose after just 2 months..Food noise was hitting me on day 5, I decided to go to every 5 days (maybe you want to try that?) it worked for me a bit too much, so, I went back to 7 days and added Cagri.
I started very low (just 125mcg's) Actually just started yesterday and wow..I felt very full after just 6 or 7 hours after pinning. I'm at day 2 and I just had a light breakfast and wow, full again...Glass of water? Full! so...If Tirz and Cagri isn't working for you, like I said, maybe use the GLP pllotter https://glp1plotter.com/ and move to a 5 or 6 day schedule?
Good luck with your research!
 
BadLouie said:
Like many of you, I have a food problem. I'm hungry, I'm always hungry. So, what I specifically need is something to reduce the food noise.

I recently started my research on Cagri. I've read many stories about how strong it was for food noise suppression. My experience has not been what I expected.

Background.

I've been taking GLP medication for 2 years not. Currently taking 15mg Tirz weekly. I gained tolerance quite quickly and have really seen no kind of notable results after 10mg weekly. Early on it had great results, now I feel it VERY little. I briefly tried adding Sema to my regimen specifically for the food noise suppression. I had nearly no response at all, I was completely convinced I had fake product because a 2.5 had literally no effect on me even with the Tirz. My GF tried it and 6 months later she is down probably 60lbs and thinks its a miracle drug, so yeah its real and works lol. I stopped after a month.

I then tried a 90 day break. I def noticed i was absolutely starving after a couple weeks off but it subsided after a bit. I then jumped back on the tirz excited to get back after my tolerance break. Unfortunately, by the 3rd week my tolerance had come back. I was back to having no noticeable effect.

Then I tried RETA. Wow what a waste of time and money. I quickly reached 12mg weekly and I felt nothing at all. After going through several bottles, I just put it back on the shelf.

Now on to Cagri.
Week 1- .25 mg dosage with the 15mg tirz. Very mild stomach discomfort.
Week 2- .5 mg with 15mg tirz. Still nothing really of note.
Week 3- 1mg with 15 tirz. Now we got something... Felt similar to Tirz working, def helped for about 5 days.
Week 4- 1mg with 15 tirz, Maybe 15 minutes of feeling like i need to burp.
Week 5- 1mg with 15 tirz, not even a grumble.
Week 6- I think im going to step up again, try a 1.5

Is it common to have such a tolerance for these medications? Everyone I know that uses these is having much more of a response than I am. My gf is on like .5mg sema and having great results, Mother 7.5 tirz and works wonderfully. I'm feeling a bit lost here. I think my next experiment will be with just larger doses of Tirz since it's the only one I've had good results with. I've seen some posts about people exceeding 20mg. That seems to be the path.

Have you tried Cagri and been unimpressed with the hype?
Do you know of any cheat codes i dont?
What could be unique with me that im not responding as well as so many others?
Click to expand...
I think you can do 4.5mg a week on cagri
 
I notice much of the OP seems to be assessing results based on how the OP "feels" when using a certain compound. To be sure, OP, were you also tracking your weight during these periods and verified that no changes were occurring there? If you're not tracking weight changes and just going off of perceived appetite, that's probably not going to be very objective. You're also going to be hyperfixated on appetite and food noise, if those are the variable you're tracking the most closely, which may cause them to seem greater simply due to your fixation on them.

Assuming weight loss has been stalled this entire time, as others have noted, there's massive variability in results from person to person. I don't have a link to it handy, but if you can hunt down the phase 2 data supplement for retatrutide, the variability is insane. There was one person in the placebo group who lost over 20% of their body weight during the trial. Meanwhile, there were several people on 4mg/week who actually gained weight during the trial!

An interesting thought problem (that would be impossible to study, short of developing portals to other dimensions) is pondering how the result for a given person would vary, depending on if they were on different dosage levels of a given med. For example if I ran a 48 week trial on you at 2mg, hit the rewind button on time, and then ran the same 48 week trial on you at 4mg, 8mg, etc. how would your results vary? The closest we can come to estimating what that result might be is to look at the results achieved by the top 5% and bottom 5% losers for each dosage level. These can be eyeballed from the "waterfall" plots. In the case of retatrutide, I'm seeing:

Worst 5%:
Placebo: ~+5%
1mg: ~-1%
4mg: ~-3%
8mg: ~-6%
12mg: ~-6%

Best 5%:
Placebo: ~-14%
1mg: ~-30%
4mg: ~-38%
8mg: ~-40%
12mg: ~-42%

And that's for retatrutide, arguably the "best" that's currently available. Sadly, for ~5% of people, even at the highest dosages, they're going to be quite underwhelmed by their results.
 
It's amazing how different we all are, Tirz. immediately killed my appetite at even the lowest doses. Unfortunately it gave me severe Gerd and tons of other side effects so I quit at 7.5mg.
I'm much happier on Reta, very mild so far except for some fatigue.

What about adding something like Contrave (naltrexone/bupropion) to deal with appetite suppression separately?
 
BadLouie said:
Like many of you, I have a food problem. I'm hungry, I'm always hungry. So, what I specifically need is something to reduce the food noise.

I recently started my research on Cagri. I've read many stories about how strong it was for food noise suppression. My experience has not been what I expected.

Background.

I've been taking GLP medication for 2 years not. Currently taking 15mg Tirz weekly. I gained tolerance quite quickly and have really seen no kind of notable results after 10mg weekly. Early on it had great results, now I feel it VERY little. I briefly tried adding Sema to my regimen specifically for the food noise suppression. I had nearly no response at all, I was completely convinced I had fake product because a 2.5 had literally no effect on me even with the Tirz. My GF tried it and 6 months later she is down probably 60lbs and thinks its a miracle drug, so yeah its real and works lol. I stopped after a month.

I then tried a 90 day break. I def noticed i was absolutely starving after a couple weeks off but it subsided after a bit. I then jumped back on the tirz excited to get back after my tolerance break. Unfortunately, by the 3rd week my tolerance had come back. I was back to having no noticeable effect.

Then I tried RETA. Wow what a waste of time and money. I quickly reached 12mg weekly and I felt nothing at all. After going through several bottles, I just put it back on the shelf.

Now on to Cagri.
Week 1- .25 mg dosage with the 15mg tirz. Very mild stomach discomfort.
Week 2- .5 mg with 15mg tirz. Still nothing really of note.
Week 3- 1mg with 15 tirz. Now we got something... Felt similar to Tirz working, def helped for about 5 days.
Week 4- 1mg with 15 tirz, Maybe 15 minutes of feeling like i need to burp.
Week 5- 1mg with 15 tirz, not even a grumble.
Week 6- I think im going to step up again, try a 1.5

Is it common to have such a tolerance for these medications? Everyone I know that uses these is having much more of a response than I am. My gf is on like .5mg sema and having great results, Mother 7.5 tirz and works wonderfully. I'm feeling a bit lost here. I think my next experiment will be with just larger doses of Tirz since it's the only one I've had good results with. I've seen some posts about people exceeding 20mg. That seems to be the path.

Have you tried Cagri and been unimpressed with the hype?
Do you know of any cheat codes i dont?
What could be unique with me that im not responding as well as so many others?
Click to expand...

Although it seems to be very rare, something for low responders to consider is the possibility that they might have developed some level of antibodies to their peptide.

A study affiliated with EL noted that one study participant developed “anti-drug antibodies” to Reta.

To be clear, I do not know exactly what this means scientifically. It just stuck out to me.

I have attached the paper. The sentence is on the bottom of p. 1241 (Don’t worry - that’s the page number in the journal. It’s on page 9 of the attached pdf, which is only 24 pages.)
 

Attachments

Retazempic said:
Although it seems to be very rare, something for low responders to consider is the possibility that they might have developed some level of antibodies to their peptide.

A study affiliated with EL noted that one study participant developed “anti-drug antibodies” to Reta.

To be clear, I do not know exactly what this means scientifically. It just stuck out to me.

I have attached the paper. The sentence is on the bottom of p. 1241 (Don’t worry - that’s the page number in the journal. It’s on page 9 of the attached pdf, which is only 24 pages.)
Click to expand...
Not that uncommon, really. See Table 3 in the phase 2 trial here:

Looks like 9% of study participants developed anti-drug antibodies. Although I'm not sure I understand the full significance and meaning of that being detected. Most surprisingly, one of those people was even in the placebo group! Not sure if that's a fluke, there's some deeper meaning I'm not understanding, or if one of the "placebo" people secretly took gray market reta during the trial. I guess that could explain how that one person in the placebo group lost 20% of their body weight! Or maybe the researchers screwed up and mixed up study participants. I'd like to believe they would have controls in place such that it couldn't happen, though.
 
BadLouie said:
Like many of you, I have a food problem. I'm hungry, I'm always hungry. So, what I specifically need is something to reduce the food noise.

I recently started my research on Cagri. I've read many stories about how strong it was for food noise suppression. My experience has not been what I expected.

Background.

I've been taking GLP medication for 2 years not. Currently taking 15mg Tirz weekly. I gained tolerance quite quickly and have really seen no kind of notable results after 10mg weekly. Early on it had great results, now I feel it VERY little. I briefly tried adding Sema to my regimen specifically for the food noise suppression. I had nearly no response at all, I was completely convinced I had fake product because a 2.5 had literally no effect on me even with the Tirz. My GF tried it and 6 months later she is down probably 60lbs and thinks its a miracle drug, so yeah its real and works lol. I stopped after a month.

I then tried a 90 day break. I def noticed i was absolutely starving after a couple weeks off but it subsided after a bit. I then jumped back on the tirz excited to get back after my tolerance break. Unfortunately, by the 3rd week my tolerance had come back. I was back to having no noticeable effect.

Then I tried RETA. Wow what a waste of time and money. I quickly reached 12mg weekly and I felt nothing at all. After going through several bottles, I just put it back on the shelf.

Now on to Cagri.
Week 1- .25 mg dosage with the 15mg tirz. Very mild stomach discomfort.
Week 2- .5 mg with 15mg tirz. Still nothing really of note.
Week 3- 1mg with 15 tirz. Now we got something... Felt similar to Tirz working, def helped for about 5 days.
Week 4- 1mg with 15 tirz, Maybe 15 minutes of feeling like i need to burp.
Week 5- 1mg with 15 tirz, not even a grumble.
Week 6- I think im going to step up again, try a 1.5

Is it common to have such a tolerance for these medications? Everyone I know that uses these is having much more of a response than I am. My gf is on like .5mg sema and having great results, Mother 7.5 tirz and works wonderfully. I'm feeling a bit lost here. I think my next experiment will be with just larger doses of Tirz since it's the only one I've had good results with. I've seen some posts about people exceeding 20mg. That seems to be the path.

Have you tried Cagri and been unimpressed with the hype?
Do you know of any cheat codes i dont?
What could be unique with me that im not responding as well as so many others?
Click to expand...
I think you might benefit somewhat from stacking cagri with tirzepatide or semaglutide, or both. Don't be afraid to go beyond current max dose either. Some people are doing 20mg tirzepatide with no issue.
 
I'm so sorry that the magic isn't working for you. That would break my heart.

Have you already examined for psychological factors? I don't know you or know anything about your life, so please don't think I'm judging you or assuming anything about you, but for those of us who come from a BED background, the physical effects on hunger/satiety/appetite/digestion sometimes don't translate all the way over to "I do not have the constant urge to eat." It doesn't for me, and I'm on tirz AND survo. They make it much, MUCH easier for me to not eat all of the food all of the time, but I've never experienced the "I put something really good in the fridge and then forgot about it" that I hear other people talking about.
 
Stimulants may also help give a weight loss boost in the short term, such as seeing an obesity specialist about phentermine. Jardiance is another option for polypharmacy (and the brand name is available direct from India).

For potentially aggressive stacking, I like the posts by @Super Trips, at least for the shock value.
 
Last edited:
Calm Logic said:
Stimulants may also help give a weight loss boost in the short term, such as seeing a doctor about phentermine. Jardiance is another option for polypharmacy (and the brand name is available direct from India).

For potentially aggressive stacking, I like the posts by @Super Trips, at least for the shock value.
Click to expand...
I got all excited on one of them, and thought I'd found a new drama thread to read, then discovered midway through that I was an active participant in it. Man, my memory is NOT what it used to be, and I'm not old enough for that to be the case!
 
So I had this issue with tirzepatide, i was on 15mg weekly and it just stopped working altogether and i was putting weight back on fast.

I stopped and restarted after leaving it 1-2 months and still nothing even when i ramped back up to 15mg again.

So i took a break - i put on shit loads of weight. almost ended up where i was before i started.
Started again on reta probably 6-7 months after id stopped taking tirz and it hit me like a truck - was on 2mg and the suppression was crazy.
I honestly think your body just builds up tolerance to it and unfortunately you need to give it a break and start again in a while.
 
theway85 said:
So I had this issue with tirzepatide, i was on 15mg weekly and it just stopped working altogether and i was putting weight back on fast.

I stopped and restarted after leaving it 1-2 months and still nothing even when i ramped back up to 15mg again.

So i took a break - i put on shit loads of weight. almost ended up where i was before i started.
Started again on reta probably 6-7 months after id stopped taking tirz and it hit me like a truck - was on 2mg and the suppression was crazy.
I honestly think your body just builds up tolerance to it and unfortunately you need to give it a break and start again in a while.
Click to expand...
Perhaps the switch to reta had a lot to do with it adding a pathway to the mix could be the ticket.
 
Cagri stopped working for me but I may have a bad batch. I finished a batch from Nexa then had no suppression when I switched to my SRY batch (no 3rd party testing). I’ve titrated up on the SRY from 1.25mg to 4mg and have felt nothing. I may give the cagri to my son to try. I will likely skip cagri at this point as I’m trying to rely more on good habits rather than increased appetite suppression as I get closer to goal weight.

On another note, I did a 48 hour water fast this week and noticed a big boost in appetite suppression following the fast. I typically maintain an 18/6 fast/eating schedule and shoot for a 48-60 hour monthly water fast. I’m currently on 12mg tirz but was up to 15mg for a few weeks. I decided to reduce the tirz dose to a level where I am still losing weight albeit slowly (1 lb/month) and manage any food noise/appetite via better habits.
 
I thought, Tirz low responders is about 10-15 % and non about 5-10 % ?
It 's not rare to not respond.
I had absolutely no effect of Sema, but Tirz was amazing from first shot 2,5 mg
It's just very individual.
You could stack, or you could try Maz or Survo out, or higher doses.
 
Last edited:
I'm convinced that you can take full dose and you can literally just saturate and it stops working. Then you need to take a big break to reset if it happens and start again.
 
theway85 said:
I'm convinced that you can take full dose and you can literally just saturate and it stops working. Then you need to take a big break to reset if it happens and start again.
Click to expand...
It seems much more likely that the "therapeutic range" would be different in non-responders. You get much fewer non-responders at the highest dosage levels, suggesting that as dosage level increases, non-responders are converted to responders.

It's just not clear what that means, since nobody has run clinical trials that test non-responders at mega-doses so at best we would have N=1 data on that. And it's unclear if doing so would be safe or not.
 
Retazempic said:
It might stop working bc ppl’s metabolism slows down bc they’re not eating enough and the body adapts

Look into “reverse dieting”

It worked for me
Click to expand...
People often confuse "stop working" with reaching the maximum effect for a given situation.

Stop Working implies gaining back all the weight you lost. Other than 1 person in this thread claiming that happened to them, this is unheard of in the community and the scientific trials.

Reaching the maximum effect happens all the time with most drugs. You will loose weight until a certain point at which the drug and your body reach an equilibrium. You might even gain a small amount of weight from there but not much and slowly. In order to loose more weight, you need to change something else. more drugs, different drugs, focus on your diet or exercise, etc...
 
thatkatmat said:
I'm currently doing 5mg Tirz and didn't want to up my dose after just 2 months..Food noise was hitting me on day 5, I decided to go to every 5 days (maybe you want to try that?) it worked for me a bit too much, so, I went back to 7 days and added Cagri.
I started very low (just 125mcg's) Actually just started yesterday and wow..I felt very full after just 6 or 7 hours after pinning. I'm at day 2 and I just had a light breakfast and wow, full again...Glass of water? Full! so...If Tirz and Cagri isn't working for you, like I said, maybe use the GLP pllotter https://glp1plotter.com/ and move to a 5 or 6 day schedule?
Good luck with your research!
Click to expand...
I'm on week 3, didn't feel much after week 2 and another .125, so...went up to .25 and i can feel it again, low and slow for me. Hopefully it lasts a little longer than the last dose...(just an update) Cheers!
 
thatkatmat said:
I'm on week 3, didn't feel much after week 2 and another .125, so...went up to .25 and i can feel it again, low and slow for me. Hopefully it lasts a little longer than the last dose...(just an update) Cheers!
Click to expand...
You know that it takes a full month for the effect of any given dose to take effect right? Changing your dose every week means you never reach equilibrium.
 
zpped said:
You know that it takes a full month for the effect of any given dose to take effect right? Changing your dose every week means you never reach equilibrium.
Click to expand...
Yes, I understand that. that's why I waited until week 3 as I was on a preclinical dose to get the feel of it and made the decision to move up to a more typical starting dose of .25. I appreciate the input.
 
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