Is 4mg+ really the key?

Bruh132

Bruh132

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I’ve seen a lot of back and forth on whether or not 4mg or more is where you truly get the benefits of Retatrutide compared to Trizepitide. To my understanding the argument supports that the Glucogon agonist doesn’t really get activated until you hit the 4mg+ a week. I’ve titrated up from .5mg to 4mg over a course of an couple of months and have been cruising there for about 3 weeks and haven’t really noticed anything different effect wise (Other than the continuous benefits of Reta obviously lol). Can anyone share their own experience?
 
I am curious to that number as well. I am only at .75mg twice a week. But I only had 15lbs to lose. Mostly visceral fat.
 
Bruh132 said:
I’ve seen a lot of back and forth on whether or not 4mg or more is where you truly get the benefits of Retatrutide compared to Trizepitide. To my understanding the argument supports that the Glucogon agonist doesn’t really get activated until you hit the 4mg+ a week. I’ve titrated up from .5mg to 4mg over a course of an couple of months and have been cruising there for about 3 weeks and haven’t really noticed anything different effect wise (Other than the continuous benefits of Reta obviously lol). Can anyone share their own experience?
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When I was researching/learning for my transition from Tirz to Reta, the range I settled on for meaningful GCGR activation was 6-8mg, so I made it a point to get to that point quickly. I got to 8mg in early Feb, ~35lb ago.

I'm decidedly not avoidant of higher doses, I'm down 55lb I still have ~40lb to go. No regrets thus far, things are going better than I expected/projected.
 
I've done a year+ at 4mg, and still don't like 6mg. I tried 8 mg a few months ago and it was some bullshit I had a hard time with protein shakes and I pooped 3 times in 2 weeks.

So yeah, n=1 here but 4mg is definitely the sweet spot, I don't have any side effects at all it's perfect I'm going to stay on this indefinitely.
 
It depends mostly on how much weight you are trying to lose.
If you want to lose 10kg 4mg might be too much, if you want to lose 50kg 4mg is very unlikely to be enough.
For people without significant obesity , low dose reta is probably a good option, 1mg of reta for a year caused 9% weight loss, much more than low doses of sema or tirz. And many many people on this forum without obesity seem to get good results from low doses of reta, in the 1-4mg range. So I do not think 4mg is anything special. And individual responses vary a lot. For some people 1mg causes side effects and huge decreases in appetite for others it might take 10mg to have that effect.
The glucagon agonism is going to be happening at all doses, you might need bigger doses to be able to measure changes in energy expenditure from reta, but I think that has more to do with the precision of the testing than the way the drug works.
And you need to adjust the doses based on effects on weight loss and hunger and side effects, if you are hungry or not losing weight then increase dose so long as side effects are not a problem.
 
Bruh132 said:
I’ve seen a lot of back and forth on whether or not 4mg or more is where you truly get the benefits of Retatrutide compared to Trizepitide. To my understanding the argument supports that the Glucogon agonist doesn’t really get activated until you hit the 4mg+ a week. I’ve titrated up from .5mg to 4mg over a course of an couple of months and have been cruising there for about 3 weeks and haven’t really noticed anything different effect wise (Other than the continuous benefits of Reta obviously lol). Can anyone share their own experience?
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Based on my personal experience so far it seems to be the case for me. I initially in my first 4 weeks starting off at 1 mg and then titrating up to 2 mg, lost a total of 14 lbs but then it sort of stagnated from there and i plateaued. 2 weeks of no weight loss until i then titrated up to 3 mg and realized food noise was slowing down and didnt have any more side effects so bumped it up to 4 and ive lost an additional 5 lbs so far since then.
 
I always say, biology in general is not maths. And not always 2+2 =4. There's no one rule, because all depends on a particular - personal case. But like above was said the less you need to lose, the lower dose will do for you. Also it matters whether you have some activity or not, your diet etc...
 
Have you found that it takes more mg of Reta for the same effect as less mg of Tirz?
 
Mz-Ace said:
4 m g was my sweet spot 👌
Real game changer from that dose onwards & I haven't exceeded 6 m g.
Journey has been 8 + months personally.
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Wait till you hit 8mg. Wife and I kind of slowed down/stalled on the last 2 6mg and two weeks at 7mg. Started 8mg and zing, appetite suppression is back, weights down 3.2lbs on my Tuesday check. BMI was down .5 and BF down .6% in 4 days
 
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JimGainz said:
Have you found that it takes more mg of Reta for the same effect as less mg of Tirz?
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A couple things here-

You should not ever practically compare mg dosage of any of the different GLP meds. When speaking of the general scope/range of dosages: 2mg of Semaglutide will never be close to 2mg of Tirzepatide, which will never be close to 2mg of Retatrutide, as threshold limits and therefore scale, are all very different.

Aside from that, it really depends what “effect” you’re trying to use as a metric.. I’m going to go on a limb and say you’re talking about food suppression? If so, always keep in mind that the primary agonist weight for Reta is not focused on food suppression like it is for Tirz/Sema. If that effect is your primary litmus of whether a GLP is “working” or not then Tirz or Sema are significantly better options.

Food suppression intensity on Reta comes different for everyone and at different dosages, but to simply answer your question (now that I’ve placed context)- yes it will take more mg of Reta than Tirz to achieve similar food suppression. This is by design, as again, suppression shouldn’t be the only metric for efficacy when discussing Reta.
 
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Bruh132 said:
I’ve seen a lot of back and forth on whether or not 4mg or more is where you truly get the benefits of Retatrutide compared to Trizepitide. To my understanding the argument supports that the Glucogon agonist doesn’t really get activated until you hit the 4mg+ a week. I’ve titrated up from .5mg to 4mg over a course of an couple of months and have been cruising there for about 3 weeks and haven’t really noticed anything different effect wise (Other than the continuous benefits of Reta obviously lol). Can anyone share their own experience?
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From what I can tell it's different for everyone. When I hit 4 mg the glucagon agonist really seemed to get turned on.
 
I started seeing the different at 4mgs. But again, I also started at 4mgs after 4 weeks, and many people say that 4 weeks is actually the key. But 4mgs at 4 weeks really started the weight loss for me.
 
DragonOfTheSea said:
A couple things here-

You should not ever practically compare mg dosage of any of the different GLP meds. When speaking of the general scope/range of dosages: 2mg of Semaglutide will never be close to 2mg of Tirzepatide, which will never be close to 2mg of Retatrutide, as threshold limits and therefore scale, are all very different.

Aside from that, it really depends what “effect” you’re trying to use as a metric.. I’m going to go on a limb and say you’re talking about food suppression? If so, always keep in mind that the primary agonist weight for Reta is not focused on food suppression like it is for Tirz/Sema. If that effect is your primary litmus of whether a GLP is “working” or not then Tirz or Sema are significantly better options.

Food suppression intensity on Reta comes different for everyone and at different dosages, but to simply answer your question (now that I’ve placed context)- yes it will take more mg of Reta than Tirz to achieve similar food suppression. This is by design, as again, suppression shouldn’t be the only metric for efficacy when discussing Reta.
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Have you ever seen anything 'real' in terms of conversions, especially from Tirz->Reta? I keep poking around in the studies or patents to try to figure out how the 'ratio' changed from last gen to next gen but can't really seem to narrow it down.
 
The sweet spot is your sweet spot. I am losing on avg 2lbs a week. 4 days at gym, walks most nights 1.5 miles. Tracking 90% of food to the gram, I work at home , it's easy. I do cardio 3-4 hrs a week - road bike riding. Without the extras my weight loss would be less but I have almost no side effects , I wanted to go low dose as possible and slowly move down. I did not want nasia, I wanted to be able to eat any meal within reason and be active.


I did .5mg for a month, then .8mg. 1mg and just pinned 1.3mg.

If a sweet spot exists it might be for folks only pinning reta vs all the other things one should consider doing w it. Just my 2 cents 🙂
 
LongevitybroTX said:
Have you ever seen anything 'real' in terms of conversions, especially from Tirz->Reta? I keep poking around in the studies or patents to try to figure out how the 'ratio' changed from last gen to next gen but can't really seem to narrow it down.
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I think you missed my point, my man. You should not be looking at any “conversion” so to speak, they behave differently, and your body will behave differently. Best course of action is to give it a go with responsible titration and listen to your body.
 
BNLFL said:
Wait till you hit 8mg. Wife and I kind of slowed down/stalled on the last 2 6mg and two weeks at 7mg. Started 8mg and zing, appetite suppression is back, weights down 3.2lbs on my Tuesday check. BMI was down .5 and BF down .6% in 4 days
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I need all the zing I can get !! 😉
 
Reta melted the fat off my body at 1mg twice a week. It went after the fatty parts I would have preferred to keep first. Then it started on my stomach and arms.

I was getting full benefits and some side effects at that dose and when I tried to move up to 1.5 on the misguided idea that I’d see “full benefits” at higher doses I got good and sick instead.

We are all designed differently. Listen to your body.
 
I didn’t see any loss at 12mg and even then had to add a couple mg of tirz to round it out. That broke a 6 month or so stall. However long it took to titrate Reta to 12
 
I am seeing slow fat loss with low dose, .75mg twice a week. I am moving to 1mg twice a week. But I also take Tesa/Ipa blend and Mots-c…
 
I was wondering the same thing. Both my wife and I are on around 1mg weekly with the aim to turn some fat into muscles rather than purely lose weight. I am still playing to find the sweet spot, likely we will stay around 0.8 - 1.2 for now. With these dosages we did see, particularly in my wife, an increase in heart rate, which according to my research on the internet is an indicator of glocagon response.

The 4mg (and I would prefer not to go that far myself) come from the fact that during the Eli Lilly trials BHB - the ketone the body makes through fat oxidation - became clearly measurable in the participants blood samples, well later than measurable acivation of GLP1 and GIP (EC50 for glucagon activation is nearly 10x that of the other receptors, meaning it is a lot slower to achieve its full (or half in that case) effect. )

One more thing: There is a likely a big difference from person to person. From a ketogenic (ultra low carb) diet that keeps you in a fatburnign state I know that some people are very quick to go into a keto state (= produce BHB) and others, particularly those which are heavily overweight and were used to eating throughout the day) take a lot longer since the body "forgot" how to make ketones. Going into Keto, sometimes adding a BHB salt can help in that situation since having BHB in the blood can support the body to acticate the creation of BHB by the liver. If that is in ANY way at all appliccable for Reta I have no idea, but what I take from that is that bodies react very differntly to a number of factors.
 
I should have added, I am not trying to loose a lot of weight. Maybe 10 pounds total. I already have abs, not too much sub fat but I have visceral fat. I have lost a lot in 3 months with those stack, just looking to loose as much as possible for health reasons.
So the reta dosage really depends on what you are trying to achieve…
 
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