is there any hope of getting vendors to offer SS-31 at standard dosages?

[clayd]

SS-31 appears to be a very promising drug candidate with a host of potential benefits, including improved vision, brain health, cleaning up of free radicals, movement/mobility, and exercise performance.

but the clinical trials i've read use dosages of 40-60mg/day for like 24 weeks. That's between 6700mg and 10000mg for a full course. Currently vendors sell kits with 100-250mg for the $100-200 range approximately, meaning you'd need 25-30 kits for a full course. That's over $5000.

the peptide people seem to like 2-4mg doses daily, but it would be good if the vendors wanted to compete on a full regimen for a reasonable price.
is there any chance of engaging with vendors to make this happen? or are they just selling stuff with a markup vs. their production cost?

 

[RocketGotRobbed]

Those are therapeutic disease-targeting doses aimed at sick populations (mitochondrial myopathy, heart failure, Barth syndrome) where aggressive intervention was justified. When longevity clinics began recommending a much smaller dose for us labrats, it was because:
1. Risk vs. reward — If not in a disease state like end-stage cardiomyopathy, then you’re layering SS-31 into a broad longevity / optimization protocol with others (think NAD+, MOTS-c, Retatrutide, KLOW, etc.) A lower “signal dose” is more about nudging mitochondrial resilience rather than going all-in on a pharmaceutical-strength rescue.
2. Safety + supply — Most physicians using SS-31 off-label in wellness/athletic settings use 5–10 mg SC daily or every other day, an order of magnitude lower, and still report subjective improvements in recovery, endurance, or fatigue. Once these anecdotal findings spread through the community, others joined in and found similar success.

There are many reports from clinics who pushed clientele near clinical doses and found no additional benefits. But I get it.

 

[rkl123]

Those are therapeutic disease-targeting doses aimed at sick populations (mitochondrial myopathy, heart failure, Barth syndrome) where aggressive intervention was justified. When longevity clinics began recommending a much smaller dose for us labrats, it was because:
1. Risk vs. reward — If not in a disease state like end-stage cardiomyopathy, then you’re layering SS-31 into a broad longevity / optimization protocol with others (think NAD+, MOTS-c, Retatrutide, KLOW, etc.) A lower “signal dose” is more about nudging mitochondrial resilience rather than going all-in on a pharmaceutical-strength rescue.
2. Safety + supply — Most physicians using SS-31 off-label in wellness/athletic settings use 5–10 mg SC daily or every other day, an order of magnitude lower, and still report subjective improvements in recovery, endurance, or fatigue. Once these anecdotal findings spread through the community, others joined in and found similar success.

There are many reports from clinics who pushed clientele near clinical doses and found no additional benefits. But I get it.

There's also the fact that even amongst the folks it is designed for/tested on it has hardly done anything. It's trials have been quite mediocre.

 

[clayd]

There's also the fact that even amongst the folks it is designed for/tested on it has hardly done anything. It's trials have been quite mediocre.

I wouldn't expect its effects to be super visible to the layperson

 

[clayd]

Those are therapeutic disease-targeting doses aimed at sick populations (mitochondrial myopathy, heart failure, Barth syndrome) where aggressive intervention was justified. When longevity clinics began recommending a much smaller dose for us labrats, it was because:
1. Risk vs. reward — If not in a disease state like end-stage cardiomyopathy, then you’re layering SS-31 into a broad longevity / optimization protocol with others (think NAD+, MOTS-c, Retatrutide, KLOW, etc.) A lower “signal dose” is more about nudging mitochondrial resilience rather than going all-in on a pharmaceutical-strength rescue.
2. Safety + supply — Most physicians using SS-31 off-label in wellness/athletic settings use 5–10 mg SC daily or every other day, an order of magnitude lower, and still report subjective improvements in recovery, endurance, or fatigue. Once these anecdotal findings spread through the community, others joined in and found similar success.

There are many reports from clinics who pushed clientele near clinical doses and found no additional benefits. But I get it.

Appreciate this reply, would love to read up on these longevity/wellness results if you have some links. Thanks for the explanation

 

[rkl123]

I wouldn't expect its effects to be super visible to the layperson

I’m saying the effects are hardly seen even in the folks it is tailor made for who are hand selected for the studies.

 

[peptidepower77]

There were some CFS/ME guys on Reddit that tried it, they almost felt 10mg per day was too much. So YMMV. I think there is still value in a lower dose myself.

 

[Peotidethrowaway]

I take 4mg personally. I’ve seen some chatter that testing at lower doses has found it to be effective

 

[desinr-gal]

Those are therapeutic disease-targeting doses aimed at sick populations (mitochondrial myopathy, heart failure, Barth syndrome) where aggressive intervention was justified. When longevity clinics began recommending a much smaller dose for us labrats, it was because:
1. Risk vs. reward — If not in a disease state like end-stage cardiomyopathy, then you’re layering SS-31 into a broad longevity / optimization protocol with others (think NAD+, MOTS-c, Retatrutide, KLOW, etc.) A lower “signal dose” is more about nudging mitochondrial resilience rather than going all-in on a pharmaceutical-strength rescue.
2. Safety + supply — Most physicians using SS-31 off-label in wellness/athletic settings use 5–10 mg SC daily or every other day, an order of magnitude lower, and still report subjective improvements in recovery, endurance, or fatigue. Once these anecdotal findings spread through the community, others joined in and found similar success.

There are many reports from clinics who pushed clientele near clinical doses and found no additional benefits. But I get it.

Thank you for this information

 

[RocketGotRobbed]

Personally, I run 5mg per day for 28 days and then shift immediately to MOTSc

 

[RocketGotRobbed]

Appreciate this reply, would love to read up on these longevity/wellness results if you have some links. Thanks for the explanation

It's not so much scholarly, peer reviewed articles as it is reading through websites, blogs, forums regarding longevity clinics and actually conversations with longevity folks in the clinics. I attended one for 2 years from 2010 until early 2012 and still have several contacts in the community. But one such link would be https://revolutionhealth.org/blogs/news/peptide-therapy-ss-31 wheree they comment on thheir use of 4mg per day. If you reach out to them, I am sure you will get a breakdown of what they have found in their clientele anecdotally.

 

[RocketGotRobbed]

Appreciate this reply, would love to read up on these longevity/wellness results if you have some links. Thanks for the explanation

This one was more of an actual study. But
The dosing regimen—as clearly documented in the abstract and methods—was as follows:

• Cohort 1: 0.005 mg·kg⁻¹·h⁻¹
• Cohort 2: 0.05 mg·kg⁻¹·h⁻¹
• Cohort 3 (highest dose group): 0.25 mg·kg⁻¹·h⁻¹

The article "Novel Mitochondria-Targeting Peptide in Heart Failure Treatment: A Randomized, Placebo-Controlled Trial of Elamipretide" by Daubert et al., published in Circulation: Heart Failure (2017), demonstrated that a single infusion of elamipretide was safe and well-tolerated in heart failure patients with reduced ejection fraction (HFrEF). The study found that a high dose of elamipretide was associated with favorable, short-term changes in left ventricular (LV) volumes, suggesting a potential for improving cardiac function by targeting mitochondrial bioenergetics.
Study design and purpose

• Study type: This was the first randomized, double-blind, placebo-controlled clinical trial of elamipretide in patients with HFrEF.
• Purpose: To examine the safety, tolerability, and effect of elamipretide on cardiac structure and function in heart failure patients.
• Rationale: The study was based on the premise that mitochondrial dysfunction and energy depletion are key components of heart failure, and that elamipretide, a novel peptide that targets and increases mitochondrial energy, could have a therapeutic effect.

Key findings

• Safety and tolerability: A single, short-term infusion of elamipretide was found to be safe and well-tolerated across different dose levels.
• Cardiac remodeling: In the highest dose group, patients experienced a significant reduction in left ventricular end-diastolic volume (LVEDV) and end-systolic volume (LVESV) at the end of the infusion compared to placebo.
• Mechanism of action: The favorable changes in LV volume correlated with peak plasma concentrations of elamipretide, suggesting a dose-dependent effect.
• Study limitations: The authors noted that the observed improvements in LV volumes should be considered provisional due to the small number of patients and the study's short duration. Further research was needed to determine long-term safety and efficacy.

Context and subsequent research

• This Phase I study offered encouraging preliminary evidence that targeting mitochondrial energetics could be a promising new approach for treating heart failure.

 

[RadicalCrimson]

I’ve been taking SS-31 at 10 mg/day along with MOTS-C 5mg/day, and I’m continuously extremely tired.
I think I’ll take a break.

 

[Jlykken]

I have CHFrEF RS is using 4mg 5 days per week, NAD 2x’s per week and about to add Mots, I do feel extremely tired several days out of the week. I’m not very active as my job is sit down. I know I need to move more, per my cardiologist. Idk if any of this is helping, but rs feels a jolt when using NAD and was glad to up the dosage to 100mg twice per week! I’m looking forward to adding the Mots and it’s known to also give energy.

 

[RocketGotRobbed]

I’ve been taking SS-31 at 10 mg/day along with MOTS-C 5mg/day, and I’m continuously extremely tired.
I think I’ll take a break.

Clinically and in longevity circles, these two aren’t usually stacked daily at full doses together. Instead, they’re often cycled or sequenced to prevent “metabolic overlap” and to better evaluate response. For example:

• Some clinics run SS-31 as a 4–8 week pulse, especially in situations of mitochondrial stress or cardiovascular need, then switch to MOTS-c for a longer metabolic phase.
• Others stagger them in the same protocol but inject at different times of day (SS-31 in the morning fasted, MOTS-c later with food or pre-training) to reduce any chance of competing signals. I have only seen this a couple of times.

The concern with running 10 mg SS-31 daily plus 5 mg MOTS-c daily, simultaneously and long term, is that you may be “pushing” mitochondrial pathways in two directions at once. One focused on membrane preservation, the other on energy demand signaling. In theory, this could blunt the hormetic (adaptive stress) response MOTS-c is supposed to create, or make it harder to tell which compound is providing the benefit. I am totally spitballing here but just based upon some reading.

Both SS-31 and MOTS-c can shift cellular energy dynamics pretty strongly, and fatigue is a known early effect if the system gets “pushed” too hard at once.

• SS-31 improves electron transport efficiency, but in doing so it can temporarily alter redox balance. People sometimes feel a dip in energy before things normalize, especially if their mitochondria are already stressed.
• MOTS-c activates AMPK, which is like hitting the “caloric restriction/exercise” switch. That lowers available glucose for immediate energy in favor of long-term metabolic benefits. For someone new, this can feel like running on empty.

Stacking 10 mg SS-31 + 5 mg MOTS-c daily is basically a double metabolic stressor. Instead of getting a clean performance lift, you are basically signaling “repair + fasting state” simultaneously, which can absolutely manifest as tiredness, brain fog, or lack of drive. THIS IS MY BET FOR YOU.

I would

• Run them in sequence: do 4–6 weeks of SS-31 alone, then switch to MOTS-c.
• If combining, reduce dose: for example, SS-31 at 5 mg daily + MOTS-c at 2.5 mg 2–3x per week, then titrate.
• Timing matters: SS-31 fasted in the morning tends to feel energizing for some, while MOTS-c is often better pre-workout or early afternoon with a meal, not stacked directly.

If your fatigue is already pronounced, the simplest move is to stop one of them, keep the other, and see if energy improves within 48–72 hours. That feedback will tell you quickly which compound is the culprit for making you drag.

 

[RadicalCrimson]

Thanks. I did one week of MOTS-C alone, two weeks of SS-31 alone, then both, for a month now.
The fatigue is from the last couple weeks only.