Itching Reaction all over the Body

[ItIsWell]

So I have been on Zepbound since February 2024 and I have met my goal weight. My physician has reduced me back to 10MG.

Since I started the Zepbound last year I have had the normal side effects, but I also got to experience itching all over my body. I was even taken to the hospital and they couldn't figure out why I was so itchy. They insisted it was NOT the Zepbound medication. I've also gone to the allergist and they informed me that yes I am allergic to it and she said I could stay on it as long as I take Zyrtec and she gave me Montelukast and Pepcid AC. It helps me a lot, but when I take an injection I feel the itching more for the first and 2nd day.

Has anyone else experienced that while taking the medication?

 

[GLP1Pharmacist]

No, Semaglutide is cheap and worth a shot??

 

[vewdew34]

Like he said, I would try something else I have had Hives and that itching all over its not fun.

 

[AndyPanda]

So I have been on Zepbound since February 2024 and I have met my goal weight. My physician has reduced me back to 10MG.

Since I started the Zepbound last year I have had the normal side effects, but I also got to experience itching all over my body. I was even taken to the hospital and they couldn't figure out why I was so itchy. They insisted it was NOT the Zepbound medication. I've also gone to the allergist and they informed me that yes I am allergic to it and she said I could stay on it as long as I take Zyrtec and she gave me Montelukast and Pepcid AC. It helps me a lot, but when I take an injection I feel the itching more for the first and 2nd day.

Has anyone else experienced that while taking the medication?

You could try ARA-290 for the itching if it’s related your blood sugar or some form of neuropathy, otherwise I think switching is good advice to try. Semaglutide is super cheap from China. Probably cheaper than a supply of name brand Zyrtec for the same time period that a kit will last.

 

[ZippityDooDah]

There was some clinical trial data showing that a certain percentage of people did develop allergic reactions to tirzepatide. My recollection that it didn't reach a severity that caused anything like anaphylaxis, but that it did cause some people to discontinue use. At the same time it apparently wasn't a big enough concern to result in a black box warning or even a mention of it as a possible side-effect.

It may be worth trying different antihistamines to see if there's one that does a better job than others to reduce the itching, or potentially trying sema if all else fails.