MK-0616 there’s a possibility that this may be available soon from china. It’s a pcks9 inhibitor. Science nerds please chime in.

[jg1979]

This peptide may be available soon! Does anyone know what the dosage would be? 40mg daily? Or less if pinning it? Any info would be much appreciated!

 

[FartfulCodger]

This would be really great. Let's hope it works!

From the phase 2b writeup: "Participants were assigned randomly (1:1:1:1:1 ratio) to MK-0616 (6, 12, 18, or 30 mg once daily) or matching placebo."

See https://www.jacc.org/doi/10.1016/j.jacc.2023.02.018

 

[Jfrick11]

Does anyone know what the dosage would be? 40mg daily? Or less if pinning it?

It's a PCSK9 inhibitor and you wouldn't pin it. This is the oral version of the injectable that's already available. The injectable is crazy expensive, so this would be a huge win for both convenience and cost.
In phase 2 studies they tested these dosages: 6, 12, 18, or 30 mg once daily. All showed clinically meaningful reductions of LDL-C and ApoB w/ >55% placebo-adjusted reduction observed at doses of 12 mg and higher. MK-0616 was well tolerated and there were no overall trends in AEs across treatment groups
They're in phase 3 now, targeting a 20mg dose.

 

[jg1979]

It's a PCSK9 inhibitor and you wouldn't pin it. This is the oral version of the injectable that's already available. The injectable is crazy expensive, so this would be a huge win for both convenience and cost.
In phase 2 studies they tested these dosages: 6, 12, 18, or 30 mg once daily. All showed clinically meaningful reductions of LDL-C and ApoB w/ >55% placebo-adjusted reduction observed at doses of 12 mg and higher. MK-0616 was well tolerated and there were no overall trends in AEs across treatment groups
They're in phase 3 now, targeting a 20mg dose.

Yea I saw that after. but nobody has it for injection & the suppliers in china don't yet have the injectable. they are missing out on big $$$ though. so many of us with a genetic predisposition to high LDL would go on it right away!

 

[Bioexplorer]

J

Yea I saw that after. but nobody has it for injection & the suppliers in china don't yet have the injectable. they are missing out on big $$$ though. so many of us with a genetic predisposition to high LDL would go on it right away!

Yeah, evolocumab is by far the most effective drug I've tried for lipid control. About 30% and 50% reduction in LDL and Triglycerides switching from statin. But it's costly even with good insurance and it's a royal pain getting reapproved every year because insurers suck.

It hurts my conscience a little bit buying illegal drugs still under patent protection but I could handle the guilt if a cheap knock off became available in the "gray" market. But I don't expect this any time soon. This is a large complex protein, not a simple 39 amino acid peptide. Oh well.

I'm curious if retatrutide lipid effects will be additive with Repatha or if Reta acts through the same PCSK9 inhibition pathway with minimal added improvement. I may find out in a couple months.