Mots-c Potency Loss

[ftv10hb]

Went down a research rabbit hole yesterday and came across AI reference to a finding that said reconstituted MOTS-C left at room temp for 2-3 hours could have a potency-loss of 80-90%. Looked a little further and it does have methionine and tryptophan in its sequence which apparently are 2 of the 3 peptides most prone to oxidation at room temp.

I don’t have anywhere near the scientific knowledge to judge the validity of that or the interest in looking at the sequencing of all the other common peptides out there, but wondering if those who do know better have an opinion on this or a suggestion based on that what other peptides would be most susceptible to this? I travel a lot and while I have an insulated case with a solid ice pack that works well, sometimes it’s just too long before I can get to a fridge and my peps are occasionally close to or at room temp for a bit, would love to know which ones would be better off left at home lol.

Also could this explain some of the disparity in experiences people have had with MOTS-C? For anyone that hasn’t felt much or anything while taking it, was it possibly at room temperature for a bit and that could be the cause? If a couple hours loses 80-90% I’d imagine even 30-40 minutes would have some significant effect, especially if dosing was already on the lower end

 

[Chili777]

Went down a research rabbit hole yesterday and came across AI reference to a finding that said reconstituted MOTS-C left at room temp for 2-3 hours could have a potency-loss of 80-90%. Looked a little further and it does have methionine and tryptophan in its sequence which apparently are 2 of the 3 peptides most prone to oxidation at room temp.

I don’t have anywhere near the scientific knowledge to judge the validity of that or the interest in looking at the sequencing of all the other common peptides out there, but wondering if those who do know better have an opinion on this or a suggestion based on that what other peptides would be most susceptible to this? I travel a lot and while I have an insulated case with a solid ice pack that works well, sometimes it’s just too long before I can get to a fridge and my peps are occasionally close to or at room temp for a bit, would love to know which ones would be better off left at home lol.

Also could this explain some of the disparity in experiences people have had with MOTS-C? For anyone that hasn’t felt much or anything while taking it, was it possibly at room temperature for a bit and that could be the cause? If a couple hours loses 80-90% I’d imagine even 30-40 minutes would have some significant effect, especially if dosing was already on the lower end

I've read that reconstituted Mots-C should be used within 30 days even when refrigerated. There is a study on the interwebs that shows it can have a 7% degradation at ~30 days and increasing over time. Most other peptides have a much better shelf life. I have not found the reference that AI is using, and it sounds high to me, but I wouldn't be completely surprised based on the study I read. LLMs are still somewhat suspect regarding peptides, although I think Gemini 3.0 is getting better, so I would try to find a corroborating source.

 

[ftv10hb]

I've read that reconstituted Mots-C should be used within 30 days even when refrigerated. There is a study on the interwebs that shows it can have a 7% degradation at ~30 days and increasing over time. Most other peptides have a much better shelf life. I have not found the reference that AI is using, and it sounds high to me, but I wouldn't be completely surprised based on the study I read. LLMs are still somewhat suspect regarding peptides, although I think Gemini 3.0 is getting better, so I would try to find a corroborating source.

Yea it had a citation link for it but I didn’t click through, I expected it would be a little too much science for the interest I had at that time of night lol. From my impression it did seem to imply it was something of an outlier among peptides, but I would be curious to know what a more common potency loss for a few hours at room temp is for other peptides, because if I’m losing something significant when I have long travel days then I would rather either adjust my pin schedule to leave some at home or invest in one of those electric insulin travel coolers as an upgrade over my insulated ice pack carrier.

 

[Chili777]

Yea it had a citation link for it but I didn’t click through, I expected it would be a little too much science for the interest I had at that time of night lol. From my impression it did seem to imply it was something of an outlier among peptides, but I would be curious to know what a more common potency loss for a few hours at room temp is for other peptides, because if I’m losing something significant when I have long travel days then I would rather either adjust my pin schedule to leave some at home or invest in one of those electric insulin travel coolers as an upgrade over my insulated ice pack carrier.

I think an insulated insulin travel kit with freezer packs would work in most cases for short trips. I use one, but typically stay at suite hotels with refrigerators. If that's not an option then an electric one may be best.

As far as other peptides go, I would feed them into Gemini and review the citations. I have read that Tirz is the hardiest of the bunch, but haven't investigated the more common ones. I don't think a few hours is going to have a significant effect, but I would research that.

Typo