My Cagri Chronicle: ongoing updates on progress with cag starting October 2024

are you taking vitamins or lipo-c? also liquid IV helps me out alot
Only oral vitamins. B-complex, vitamin D, methylfolate, magnesium.
if you are certain about the amount you took, yeah, that is an exceedingly small dose to get very sick on. fwiw i also bought some leftover cagrisema from someone else on here who said it made them throw up a lot, so maybe there's something in there that doesn't agree with some people.

sorry to hear it's bothering you so much. i agree with supertrips that generally electrolytes and vitamin b12 seem to help me ward off side effects but this sounds like something worse than standard side effects

i did note that novo's recent release with trial results showed only like 59% of cagrisema patients stayed on it through the whole trial, but they've been a little shifty about why...
I'm over the worst of it now. It was bad nausea for about three hours but it's settled down now that I've had some crackers and an energy drink.
You haven't had great luck lately. I am so sorry you are sick again. 😢
I appreciate the sentiment. 🥰 I'm feeling a bit better now. I've always had a weak stomach.
 
this page would not let me copy to clipboard so here's a screenshot.
10% reported allergic reactions but nobody reported serious ones. also looks like it caused some amount of gallstones and notably, half of the patients developed anti-cagri antibodies but it didn't prevent it from working.

I wonder if chmuse is having an immune response
 

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You haven't had great luck lately. I am so sorry you are sick again.
You guys are making it sound like she's been in ICU for last month or so. She perfectly fine, stop being so sorry for her😂 She's a tough girl she can handle it.
 
this page would not let me copy to clipboard so here's a screenshot.
10% reported allergic reactions but nobody reported serious ones. also looks like it caused some amount of gallstones and notably, half of the patients developed anti-cagri antibodies but it didn't prevent it from working.

I wonder if chmuse is having an immune response
I wonder if it would exacerbate existing gallstones.
 
You guys are making it sound like she's been in ICU for last month or so. She perfectly fine, stop being so sorry for her😂 She's a tough girl she can handle it.
This is why we're researchers. Sometimes when you research, you discover something new. Like the fact that I'm a weenie.
 
You guys are making it sound like she's been in ICU for last month or so. She perfectly fine, stop being so sorry for her😂 She's a tough girl she can handle it.
Puking for 3 days is not fine... that is definitely not on my bingo card.
 
Puking for 3 days
all I can say is OUCH! Yeah, that does not sound much fun. I think I've been blessed (I guess) as have yet to have ANY (and do mean ANY) side effects from peptides. Have tried at least 15 different ones already, and absolutely no side effects, nothing. The only negative I ever got was from MOT-C, it had a bit of sting at injection site, but even that was minor...
 
all I can say is OUCH! Yeah, that does not sound much fun. I think I've been blessed (I guess) as have yet to have ANY (and do mean ANY) side effects from peptides. Have tried at least 15 different ones already, and absolutely no side effects, nothing. The only negative I ever got was from MOT-C, it had a bit of sting at injection site, but even that was minor...
Aw, you deleted the other comment before I could reply. 😘 I can tell you I wasn't down for months on that one. 😁
 
Aw, you deleted the other comment before I could reply
I chickened out, 😂 my banter has gotten me in trouble before, and still may need these boards for expertise in future. Plus, new in here, don't know how tough the mods are.
I can tell you I wasn't down for months on that one.
Could be the reason for your bad reaction to the small one/dose 😂
 
I chickened out, 😂 my banter has gotten me in trouble before, and still may need these boards for expertise in future. Plus, new in here, don't know how tough the mods are.

Could be the reason for your bad reaction to the small one/dose 😂
Bee lets us get away with pretty much anything as long as we aren't political or bigoted. I'm a good sport unless I think you're a misogynist or any kind of -phobe. I found it hilarious. 😘
 
all I can say is OUCH! Yeah, that does not sound much fun. I think I've been blessed (I guess) as have yet to have ANY (and do mean ANY) side effects from peptides. Have tried at least 15 different ones already, and absolutely no side effects, nothing. The only negative I ever got was from MOT-C, it had a bit of sting at injection site, but even that was minor...
Same.. I have been EXTREMELY blessed. I have not had ANY symptoms either and it has been 3 years. Let's hope we didn't just jinx ourselves 😉
 
Is it possible to to be allergic to cagri?

Took 1ml of the vial I'd already made (6.46 mg to 3.1ml bac) and added 2ml bac in a pen to make it easier to dose. Did 6u, which is .0415mg. There's NO WAY I should feel this sick with that dose. 🤢 But maybe I'll break my stall of a month?
Yes, 10% of Novo test subjects reported allergic reactions. Ever wonder if allergic to Benzyl, or the mannitol maybe? Its almost the same volume of Mannitol in a 5mg vial or a 30mg vial, so at low doses from 5mg, you get more sugar. Ever tried just injecting Bac alone? Or Saline Bac?

Symptoms of a benzyl alcohol allergy can include hives, difficulty breathing, and swelling of the face, lips, tongue, or throat.
 
Yes, 10% of Novo test subjects reported allergic reactions. Ever wonder if allergic to Benzyl, or the mannitol maybe? Its almost the same volume of Mannitol in a 5mg vial or a 30mg vial, so at low doses from 5mg, you get more sugar. Ever tried just injecting Bac alone? Or Saline Bac?

Symptoms of a benzyl alcohol allergy can include hives, difficulty breathing, and swelling of the face, lips, tongue, or throat.
Cagri is my add on to sema, using the same bottle of hospira I used to make the sema.

I did .125mg cagri the first time and was physically ill for a few days. I did .0415mg cagri this time and had nausea a few hours in, for a few hours, which then faded. I'm okay now.
 
What is the smallest dose of Cagri you’ve taken before without the sick reaction? I was planning on starting with .025mg, but I’ve heard to start with .00125mg from some sources.
I think your numbers are off unless I wildly miscalculated. I saw starting numbers at .1-.3, so I did .125 for my dosing. If .025 is a good starting dose, buying a 5mg kit is WILD.
 
Cagri is my add on to sema, using the same bottle of hospira I used to make the sema.

I did .125mg cagri the first time and was physically ill for a few days. I did .0415mg cagri this time and had nausea a few hours in, for a few hours, which then faded. I'm okay now.
I have to take an OTC anti nausea pill when I microdose LSD (even for 5-10mcg) which helps. Also these peppermint ginger chews ward off nausea and are a nice refreshing treat after dinner.

IMG_8613.jpeg
 
I think your numbers are off unless I wildly miscalculated. I saw starting numbers at .1-.3, so I did .125 for my dosing. If .025 is a good starting dose, buying a 5mg kit is WILD.
Yep, I missed your follow up comment with your starting doses and then realized my shit math and deleted. 🤐 It is kind of a mystery for you as to whether the severe reaction is due to an allergy or a sensitivity to the cagri reaching a certain level in your blood. I wonder if it would be different with the sema completely out of your system, but that’s a risk that may not be worth the experiment.

I’ve gotta sharpen my math skills to better estimate when most of my residual Tirz and Reta will be out of my system before starting Cagri. I know that’s not necessarily a big deal, but I’m curious how it feels on its own.
 
Yep, I missed your follow up comment with your starting doses and then realized my shit math and deleted. 🤐 It is kind of a mystery for you as to whether the severe reaction is due to an allergy or a sensitivity to the cagri reaching a certain level in your blood. I wonder if it would be different with the sema completely out of your system, but that’s a risk that may not be worth the experiment.

I’ve gotta sharpen my math skills to better estimate when most of my residual Tirz and Reta will be out of my system before starting Cagri. I know that’s not necessarily a big deal, but I’m curious how it feels on its own.
I took my first dose 1/21 and was ill, then my second dose was today 2/6 (had to gather courage and wanted it 100% out of my system to try again) shortly after midnight. When I woke up I had nausea for a few hours (but was not physically ill)- it had faded most of the way by lunch, and it's now 9:30 pm and I'm still good. I have not needed to take a break from sema.
 
first week going up to 15mg tirz, also pinned 1mg cagri on the same day this time, very effective this time, was low-key nauseated/disinterested in food for a couple days but not bad. was going to add another 0.5mg cagri on thurs or friday but i haven't needed to yet.

new low weight this morning, 1.5 pounds away from my february goal so i should be easily able to get there. 7.5 pounds from my overall goal but i think that will need to be adjusted.
 
first week going up to 15mg tirz, also pinned 1mg cagri on the same day this time, very effective this time, was low-key nauseated/disinterested in food for a couple days but not bad. was going to add another 0.5mg cagri on thurs or friday but i haven't needed to yet.

new low weight this morning, 1.5 pounds away from my february goal so i should be easily able to get there. 7.5 pounds from my overall goal but i think that will need to be adjusted.
Keep pinning that cagri man. Blows everything else out of the water. Not even close. I think i'm addicted to it. Pinned my 2mg this morning again.
 
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It did not do the best in clinical trials but it sure is good for shutting off the appetite and food noise
Well, that too, but for me it does something which feels different than other GLP1's. I feel really good after a day or two taking it. I feel as if I am stronger or something and I'm more motivated to do stuff and that is a welcome feeling since I'm generally a lazy fuck LOL.
 
man, i'm getting super tempted to start pinning cagri based on these replies. i was planning to wait another 10lbs but i'm getting FOMO 😂
Don't even blink, go right ahead and go big or go home. Do it like me the very first pinning I did 4mg(by mistake btw). Everyone in here was making arrangements to send flowers to my funeral, yet I felt like flying the very next day lol. Now I'm hooked.

No, no don't do too much of a dose since some people had it real rough even though I did not have any side effects other than appetite suppression. You never know which card you'll be dealt.
 
Don't even blink, go right ahead and go big or go home. Do it like me the very first pinning I did 4mg(by mistake btw). Everyone in here was making arrangements to send flowers to my funeral, yet I felt like flying the very next day lol. Now I'm hooked.

No, no don't do too much of a dose since some people had it real rough even though I did not have any side effects other than appetite suppression. You never know which card you'll be dealt.
i've got a long weekend coming up next weekend so I may pin it depending on whether I've lost weight this week (struggling since hitting 40lbs lost!). that way if it knocks me out, I can sleep all weekend. but i'm probably gonna start at .125 😂
 
Don't even blink, go right ahead and go big or go home. Do it like me the very first pinning I did 4mg(by mistake btw). Everyone in here was making arrangements to send flowers to my funeral, yet I felt like flying the very next day lol. Now I'm hooked.

No, no don't do too much of a dose since some people had it real rough even though I did not have any side effects other than appetite suppression. You never know which card you'll be dealt.
at 1.5mg every other day or sometimes 3 days its not as bad. i added some reta 4mg to the mix and got real hunger munchies and super tired though
 
i've got a long weekend coming up next weekend so I may pin it depending on whether I've lost weight this week (struggling since hitting 40lbs lost!). that way if it knocks me out, I can sleep all weekend. but i'm probably gonna start at .125 😂
Always best to start a new thing low, you don't have to lose it all on week 1
 
Cagri is my add on to sema, using the same bottle of hospira I used to make the sema.

I did .125mg cagri the first time and was physically ill for a few days. I did .0415mg cagri this time and had nausea a few hours in, for a few hours, which then faded. I'm okay now.
I started Cagri at 0.13mg only. Still, was nauseous for a few days. 6 weeks later, am at 0.3mg. No side effects.

As a note, when I started Tirz 2.5mg with compounding Pharma, I got a month supply of Ondansetron 4mg for nausea. Was wondering what did I get myself into. Never used it for Tirz.
 
I started Cagri at 0.13mg only. Still, was nauseous for a few days. 6 weeks later, am at 0.3mg. No side effects.

As a note, when I started Tirz 2.5mg with compounding Pharma, I got a month supply of Ondansetron 4mg for nausea. Was wondering what did I get myself into. Never used it for Tirz.
I'm on a baby dose, but my stall broke, so.... I'll just titrate slow like I did with sema.

I did debate ordering some zofran. 😂
 
Are you all reconstituting with acetic acid to avoid fibrils? That stuff burns like a holy hell nightmare for me.
 
What are you guys reconstituting with? Just bac water? I have a kit of cagri and want to start my stack but unsure if it’s just bac water I mix it with
 
I'm just using bac water. I don't really buy into the fibrils scandal, I'm not shaking the vial or anything either.

I hadn't done Cagri in a long while because it gave me a low-grade nausea feeling. But I am trying it again at .25 mg. because day 5 of Tirz is rearing its ugly hungry head recently. I really think I have to up it to .5 or just below because 24-36 hrs later I'm still looking for food after dinner.
 
I'm using just bac water and am up to 1.25 after 5 months. No issues and no alien fibril or oligomer poking it's way through my abdomen. Too soon to tell on the Alzheimer's.

I still have a pulse and enough energy get dressed in my Covid quarantine sweats and go through my rigorous daily routine of reaching for the remote or phone, moving around the couch to find my skinny butt a comfy spot under a heated blanket etc... it's grueling!
 
had a hungry couple weeks after i hit a new low. felt like i wasn't on anything this week. I think that happens sometimes. I added cagri with my monday tirz shot this week, skipped the thursday cagri reup because i'm going on a weekend trip and didn't want to be tired and unable to enjoy a couple decent meals. back to hitting it hard next week.
 
I used 50% AA, 50% bac
Dude, are you sure you are doing it right? I thought I read elsewhere in these forums that the minute you add AA the vial must be pinned and what's left is garbage (it loses potency in matter of minutes or hours?). Can greater minds in here chime in as I have no clue myself on these matters and science wasn't my favorite subject at school anyway LOL.
 
Dude, are you sure you are doing it right? I thought I read elsewhere in these forums that the minute you add AA the vial must be pinned and what's left is garbage (it loses potency in matter of minutes or hours?). Can greater minds in here chime in as I have no clue myself on these matters and science wasn't my favorite subject at school anyway LOL.
Me bad. Sorry. Used AA@0.6% .
 
Me bad. Sorry. Used AA@0.6% .
ok but how about what other people are saying- That once you mix AA into the vial it should be used immediately or it goes bad, meaning if you constitute a 5mg cagri with AA and BAC water, and you use 1mg cagri, the rest is useless and can't be used since it goes bad within max an hour or so?
 
ok but how about what other people are saying- That once you mix AA into the vial it should be used immediately or it goes bad, meaning if you constitute a 5mg cagri with AA and BAC water, and you use 1mg cagri, the rest is useless and can't be used since it goes bad within max an hour or so?
I haven't heard this
 
ok but how about what other people are saying- That once you mix AA into the vial it should be used immediately or it goes bad, meaning if you constitute a 5mg cagri with AA and BAC water, and you use 1mg cagri, the rest is useless and can't be used since it goes bad within max an hour or so?
It's when you use pure BAC that it degrades faster (not that fast tho) because it's most stable in a acidic pH solution.
 
ok but how about what other people are saying- That once you mix AA into the vial it should be used immediately or it goes bad, meaning if you constitute a 5mg cagri with AA and BAC water, and you use 1mg cagri, the rest is useless and can't be used since it goes bad within max an hour or so?
People are often wrong. And moreso in a somewhat controversial topic like Cagri.
 
It's when you use pure BAC that it degrades faster (not that fast tho) because it's most stable in a acidic pH solution.
Here part of the discussion from another forum: So basically at a ph of higher than 4 supposedly (i have no proof of it) fibrils can be formed, but if you lower the ph with AA then the risk of fibrils (again supposedly) goes away, but the reconstituted cagri needs to be used ASAP or it loses effectiveness. I personally ignored such concern as people were all over the place with some claiming that the risk were very low, so I've been just constituting with BAC and using it within about 10 days. But I was wondering anyway if such claims were valid or not...
Don't they speak to the different pH levels (4 and 7.5) while subjecting Cagri to mechanical stress?

And they couldn't form any fibrils? Are you saying that this is incorrect and they didn't use the right equipment to test for formation of harmful molecules?
Fibrils are of secondary importance in this discussion. You could almost leave them out of it.

The real toxic species are oligomers. Oligomers eventually become fibrils, but they raise a lot of hell on the way.

And yes, they subjected many different amylin analogues to mechanical stress to see which ones fibrillate. Fibrils are a lot easier to detect than oligomers.

Two important points about those tests:

1. Almost every single amylin analogue fibrillated at pH 7.5 (including cagrilintide). The only one that didn't was rejected for low potency.
2. Many of the amylin analogues did *not* fibrillate at pH 4.0 (not just cagrilintide).
 
Here part of the discussion from another forum: So basically at a ph of higher than 4 supposedly (i have no proof of it) fibrils can be formed, but if you lower the ph with AA then the risk of fibrils (again supposedly) goes away, but the reconstituted cagri needs to be used ASAP or it loses effectiveness. I personally ignored such concern as people were all over the place with some claiming that the risk were very low, so I've been just constituting with BAC and using it within about 10 days. But I was wondering anyway if such claims were valid or not...

Fibrils are of secondary importance in this discussion. You could almost leave them out of it.

The real toxic species are oligomers. Oligomers eventually become fibrils, but they raise a lot of hell on the way.

And yes, they subjected many different amylin analogues to mechanical stress to see which ones fibrillate. Fibrils are a lot easier to detect than oligomers.

Two important points about those tests:

1. Almost every single amylin analogue fibrillated at pH 7.5 (including cagrilintide). The only one that didn't was rejected for low potency.
2. Many of the amylin analogues did *not* fibrillate at pH 4.0 (not just cagrilintide).
Humm. I've been using mine for 4 weeks/vial. Say more?
 
Humm. I've been using mine for 4 weeks/vial. Say more?
Me too, with plain bac water.

I don't think Novo would be proceeding with a substance as fragile and/or dangerous as some Internet virtual scientists speculate. They are even doing a small 18 wk study with both Sema and Cagri in the same chamber which is scheduled to conclude in April ('25). This timing and small size of the study could be an indicator of confidence in a singular delivery of both peptides. Novo over projected expected results with investors regarding CagriSema yet the result is a formidable competitor for tirzepatide (until Reta hits).
 
Say more?
I honestly don't know anything about it other than what I've read on some other forums in these boards, but some were saying there is a remote possibility of cagri that has a greater than PH of 4 when constituted can be problematic (may form fibrils which are dangerous supposedly) and to lower its ph people recommended using AA. However, they were saying that if you use AA then the vial needs to be used very soon (hours not days) or it loses it potency completely. But then there were some others saying the risk of fibrils is so remote that they would not be worried about it. But the consensus seemed to be it is best to use within a shorter period of time lets say within 20 days. Because I had no side effects I've actually been using a relatively high dose (2mg on days 1, 8 and 15 cause I bought the 5mg bottles that were testing 6mg +) and finishing the vial withing 15 days of constituting it with BAC. I actually bought AA but never bothered to use it since everyone was saying it destroys the potency unless used immediately. I intend to keep using it this way.
 

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