My Cagri Chronicle: ongoing updates on progress with cag starting October 2024

Just wanted to say thanks for keeping us updated! I'm so happy for you with your results. I also have 10/10 "CagriSema" in my freezer (gift from vendor) so I'm anxious to see if you proceed with the blend. I'm at 1.25 Cagri so I'd have to discontinue Tirz and start Sema separately from Cagri to work up to 1.25 to initialize and equal parts blend. Never tried Sema but I'm at goal so I can experiment.

Thx again and Happy Holidays 😁
 
nonyabizznez said:
Just wanted to say thanks for keeping us updated! I'm so happy for you with your results. I also have 10/10 "CagriSema" in my freezer (gift from vendor) so I'm anxious to see if you proceed with the blend. I'm at 1.25 Cagri so I'd have to discontinue Tirz and start Sema separately from Cagri to work up to 1.25 to initialize and equal parts blend. Never tried Sema but I'm at goal so I can experiment.

Thx again and Happy Holidays 😁
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Thank you and happy holidays! I was close to giving up on the cagri for a couple weeks but suddenly everything fell into place. This journey is fits and starts for sure.
 
Ayyy this cagrisema is some good shit
12.5 tirz Monday, 0.5 cag Thursday, 0.25/0.25 cagrisema Saturday

I feel great, not fatigued, not nauseated, but could just not care less about food this weekend.

Not intending to stay in this stack permanently, just using up some vials, but it is working well right now
 
still doing tirz 12.5mg, cagrisema 0.75mg
still working. no major sides. still losing weight.
hit a new low today, hit my january goal. my end of feb goal is another 5 pounds and now i have an extra 2 weeks to get it done.

today i took my first grey market tirz after a ousia vial ran out. not my first grey market jab though, the cag and cagrisema is all grey.

i've now lost 13 pounds since i started cagri in october to break a stall. guess it broke the stall. really seeing that paper towel roll effect lately, body is shrinking rapidly. even recent clothes are loose. i notice i look different in the mirror. and my wife finally decided to try out tirz - she only has maybe 10-15 to lose so she started at 1.25mg. says she feels nothing.

when this vial of cagrisema runs out, it's back to tirz + straight cag for me. unless maybe i pick up some cheap sema from somewhere. but the cagrisema mix is expensive.

everything is going well right now, just cruising along and stalking these forums to see what happens with the qsc drama
 
clayd said:
still doing tirz 12.5mg, cagrisema 0.75mg
still working. no major sides. still losing weight.
hit a new low today, hit my january goal. my end of feb goal is another 5 pounds and now i have an extra 2 weeks to get it done.

today i took my first grey market tirz after a ousia vial ran out. not my first grey market jab though, the cag and cagrisema is all grey.

i've now lost 13 pounds since i started cagri in october to break a stall. guess it broke the stall. really seeing that paper towel roll effect lately, body is shrinking rapidly. even recent clothes are loose. i notice i look different in the mirror. and my wife finally decided to try out tirz - she only has maybe 10-15 to lose so she started at 1.25mg. says she feels nothing.

when this vial of cagrisema runs out, it's back to tirz + straight cag for me. unless maybe i pick up some cheap sema from somewhere. but the cagrisema mix is expensive.

everything is going well right now, just cruising along and stalking these forums to see what happens with the qsc drama
Click to expand...
Sema is relatively cheap AF. If you're placing an order for anything else I'd throw a sema kit on and make your own cagrisema, if you like the combo.
 
I'm thinking of starting cagri when I'm about 20lbs from my goal weight which will actually be sooner than I think (probably a couple of months!).

did you buffer your cagri? there have been so many posts about cagri but it all devolves into arguing and i'm still confused about whether it requires buffering lol. i did buy ph strips, but nothing else yet.
 
chmuse said:
Sema is relatively cheap AF. If you're placing an order for anything else I'd throw a sema kit on and make your own cagrisema, if you like the combo.
Click to expand...
that's the conclusion i came to. i wouldn't mix the vials though so the only downside is another shot. i don't mind the shots at all, but i'm going to be riddled with holes if I'm doing 3+ per week :)
 
mopo89 said:
I'm thinking of starting cagri when I'm about 20lbs from my goal weight which will actually be sooner than I think (probably a couple of months!).

did you buffer your cagri? there have been so many posts about cagri but it all devolves into arguing and i'm still confused about whether it requires buffering lol. i did buy ph strips, but nothing else yet.
Click to expand...
I did not buffer my cagri but I don't think it's a bad idea.

Do NOT do what I tried: I read up on acetic acid and learned that's what's in household vinegar. I had a few very cheap vials of cagrisema i got secondhand. online calculators told me that 195 units of bac water + 5 units of vinegar would give me a ph of 4 so I added 5 units of vinegar to a vial and it immediately went cloudy.
I googled it and learned that the mix going cloudy means the proteins had "denatured" which means the chains unfolded and the peptides would be useless.

I did see a couple other people out there that were able to buy acetic acid on amazon and added a little to their bac water to drop the ph of their cagri successfully. I don't know why that's any different than vinegar but I guess it is. you'd have to calculate your own proportions, or just add a little bit at a time and test the ph.

here's a post in this forum with a successful ph adjustment https://glp1forum.com/threads/i-tweaked-the-ph.2200/
 
clayd said:
I did not buffer my cagri but I don't think it's a bad idea.

Do NOT do what I tried: I read up on acetic acid and learned that's what's in household vinegar. I had a few very cheap vials of cagrisema i got secondhand. online calculators told me that 195 units of bac water + 5 units of vinegar would give me a ph of 4 so I added 5 units of vinegar to a vial and it immediately went cloudy.
I googled it and learned that the mix going cloudy means the proteins had "denatured" which means the chains unfolded and the peptides would be useless.

I did see a couple other people out there that were able to buy acetic acid on amazon and added a little to their bac water to drop the ph of their cagri successfully. I don't know why that's any different than vinegar but I guess it is. you'd have to calculate your own proportions, or just add a little bit at a time and test the ph.

here's a post in this forum with a successful ph adjustment https://glp1forum.com/threads/i-tweaked-the-ph.2200/
Click to expand...
What did teh pH test at 5 units of vinegar? That seems like a lot
 
clevesand said:
What did teh pH test at 5 units of vinegar? That seems like a lot
Click to expand...
That's 0.05mL out of 2mL total, didn't seem like much to me. Sorry, I don't think I actually tested the pH after mixing it because it went cloudy. But the calculators assured me it would be right at 4.0
 
clayd said:
I did not buffer my cagri but I don't think it's a bad idea.

Do NOT do what I tried: I read up on acetic acid and learned that's what's in household vinegar. I had a few very cheap vials of cagrisema i got secondhand. online calculators told me that 195 units of bac water + 5 units of vinegar would give me a ph of 4 so I added 5 units of vinegar to a vial and it immediately went cloudy.
I googled it and learned that the mix going cloudy means the proteins had "denatured" which means the chains unfolded and the peptides would be useless.

I did see a couple other people out there that were able to buy acetic acid on amazon and added a little to their bac water to drop the ph of their cagri successfully. I don't know why that's any different than vinegar but I guess it is. you'd have to calculate your own proportions, or just add a little bit at a time and test the ph.

here's a post in this forum with a successful ph adjustment https://glp1forum.com/threads/i-tweaked-the-ph.2200/
Click to expand...
okay, I will definitely not use vinegar! 😂
 
clayd said:
That's 0.05mL out of 2mL total, didn't seem like much to me. Sorry, I don't think I actually tested the pH after mixing it because it went cloudy. But the calculators assured me it would be right at 4.0
Click to expand...
What is the purpose of adjusting the cagri to 4.0?
 
chmuse said:
Fibrils and oligomers

*jazz hands*
Click to expand...
Ah, thanks for the rabbit hole. I appear to have missed the drama while I was away.

Since I am not set up to replicate the formulation - important according to the research, simply being 4.0 is not enough, several buffers still resulted in formation. And of course being grey, we have no idea what it was manufactured with - I will stick with tirz :)

This is the final (of many) formulation settled on:
  • One (1) cagrilintide formulation at pH 4.0 was prepared, with the following composition:
  • Cagrilintide: 9.6 mg/ml
  • Glutamate: 5 mM (added as 0.74 mg/ml L-glutamic acid)
  • Glycerol: 24 mg/ml
  • Hydrochloric acid (HCl), as necessary to obtain pH 4.0
  • Sodium hydroxide (NaOH), as necessary to obtain pH 4.0
  • Water for Injection (WFI) as solvent.
 
FrankTdog said:
Ah, thanks for the rabbit hole. I appear to have missed the drama while I was away.

Since I am not set up to replicate the formulation - important according to the research, simply being 4.0 is not enough, several buffers still resulted in formation. And of course being grey, we have no idea what it was manufactured with - I will stick with tirz :)

This is the final (of many) formulation settled on:
  • One (1) cagrilintide formulation at pH 4.0 was prepared, with the following composition:
  • Cagrilintide: 9.6 mg/ml
  • Glutamate: 5 mM (added as 0.74 mg/ml L-glutamic acid)
  • Glycerol: 24 mg/ml
  • Hydrochloric acid (HCl), as necessary to obtain pH 4.0
  • Sodium hydroxide (NaOH), as necessary to obtain pH 4.0
  • Water for Injection (WFI) as solvent.
Click to expand...
Hah, sorry, I should have linked to a few of the threads. I wasn't sure I wanted to drum them up again. 😂
 
clayd said:
Ayyy this cagrisema is some good shit
12.5 tirz Monday, 0.5 cag Thursday, 0.25/0.25 cagrisema Saturday

I feel great, not fatigued, not nauseated, but could just not care less about food this weekend.

Not intending to stay in this stack permanently, just using up some vials, but it is working well right now
Click to expand...
I'm new in here and new to GLP1/peptides so pardon my ignorance but been reading elsewhere that people are worried about the PH of cagri? Do you have that issue or you been ignoring the noise around that, and do you have an opinion or a solution (to basically bring the ph under 4 of the constituted cagri). Have a bunch and being new I'm a bit scared to try. thanks,
 
Fisherman2356 said:
I'm new in here and new to GLP1/peptides so pardon my ignorance but been reading elsewhere that people are worried about the PH of cagri? Do you have that issue or you been ignoring the noise around that, and do you have an opinion or a solution (to basically bring the ph under 4 of the constituted cagri). Have a bunch and being new I'm a bit scared to try. thanks,
Click to expand...
i run it with just bac and have no problems.
just use the vial a little faster
 
Fisherman2356 said:
I'm new in here and new to GLP1/peptides so pardon my ignorance but been reading elsewhere that people are worried about the PH of cagri? Do you have that issue or you been ignoring the noise around that, and do you have an opinion or a solution (to basically bring the ph under 4 of the constituted cagri). Have a bunch and being new I'm a bit scared to try. thanks,
Click to expand...
I did try adding some vinegar to a vial but that killed the peptides and made it cloudy.

You can use bac water and add acetic acid until you get the right pH

I just use bac water
 
went straight to 1mg/1mg of cagrisema with the last dose on friday and i'll be going back down to 0.75 this week. walked around with low key nausea all weekend and into today, almost skipped my tirz dose because i still felt off and still didn't want to eat.

when this vial of cagrisema runs out i'll go back to straight cag for my stack.
 
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