I have two cents! NAD+ has low bioavailability in the oral form. Subcutaneous is better, but infusion is the best. Some people swear by NAD+, while others don’t feel anything. Because it is a little pricey, I would suggest that you try a B-Complex injection first. Something like NEUROBION, or Polibion/Polybcon that is $0.50 or less per IM injection. B3 (nicotinamide) is a precursor to NAD+ anyway and with a lot of these peptides and supplements you won’t feel much of anything unless it is something you are deficient in. I think it’s why so many people go for Clenbutetol or stimulants. It isn’t natural and you can feel it working.
| Rank | Method | Description | Potential NAD+ Impact | Key Considerations |
|---|---|---|---|---|
| 1 | NAD+ IV Therapy | Direct infusion into bloodstream. | Highest, Rapid | Medical procedure, Costly, Limited long-term data. |
| 2 | NAD+ Subq Injection | Injection under the skin. | Significant, Relatively Rapid | Requires sterile technique, Less human research than oral, Potential site reactions. |
| 3 | NR Supplements | Oral NAD+ precursor, well-studied. | Significant | Oral, Good bioavailability, Quality control important. |
| 4 | Oral NAD+ Supplements | Direct oral NAD+ delivery. | Potentially Significant (bioavailability dependent) | Oral, Bioavailability research ongoing, May require specific formulations for better absorption. |
| 5 | NMN Supplements | Oral NAD+ precursor, promising research. | Significant | Oral, Bioavailability research ongoing, Quality control important. |
| 6 | NMN Subq Injection | Injection of NMN under the skin. | Potentially Significant, May have better bioavailability than oral NMN | Requires sterile technique, Less human research than oral NMN/NR, Dosage protocols evolving. |
| 7 | High-Dose NAM | Oral Vitamin B3 precursor, high doses can inhibit sirtuins. | Moderate | Oral, Lower cost, High doses may have negative effects. |
| 8 | Sirtuin Activators | Compounds like Resveratrol, enhance NAD+ effects. | Indirect | Often dietary, Bioavailability varies, Efficacy under investigation. |
| 9 | Exercise | Regular physical activity. | Mild, Gradual | Numerous other health benefits, Sustainable. |
| 10 | Caloric Restriction/IF | Reduced calorie intake or eating windows. | Mild, Gradual | Requires planning, Not for everyone. |
| 11 | Dietary B3 | Foods containing Niacin/Nicotinamide. | Minimal | Essential for health, Dietary intake alone has limited impact on boosting NAD+. |
Below is a table from Google (Gemini). It may be horribly wrong (had to correct it twice already), but the general idea I get is that NAD+ subq looks like it may be worth the greater cost (depending on age, tolerance to oral stimulants like clen, etc). Or trying oral NR supplements (or oral NAD+ and NMN (NMNH)), like on Amazon.
Rank Method Description Potential NAD+ Impact Key Considerations 1 NAD+ IV Therapy Direct infusion into bloodstream. Highest, Rapid Medical procedure, Costly, Limited long-term data. 2 NAD+ Subq Injection Injection under the skin. Significant, Relatively Rapid Requires sterile technique, Less human research than oral, Potential site reactions. 3 NR Supplements Oral NAD+ precursor, well-studied. Significant Oral, Good bioavailability, Quality control important. 4 Oral NAD+ Supplements Direct oral NAD+ delivery. Potentially Significant (bioavailability dependent) Oral, Bioavailability research ongoing, May require specific formulations for better absorption. 5 NMN Supplements Oral NAD+ precursor, promising research. Significant Oral, Bioavailability research ongoing, Quality control important. 6 NMN Subq Injection Injection of NMN under the skin. Potentially Significant, May have better bioavailability than oral NMN Requires sterile technique, Less human research than oral NMN/NR, Dosage protocols evolving. 7 High-Dose NAM Oral Vitamin B3 precursor, high doses can inhibit sirtuins. Moderate Oral, Lower cost, High doses may have negative effects. 8 Sirtuin Activators Compounds like Resveratrol, enhance NAD+ effects. Indirect Often dietary, Bioavailability varies, Efficacy under investigation. 9 Exercise Regular physical activity. Mild, Gradual Numerous other health benefits, Sustainable. 10 Caloric Restriction/IF Reduced calorie intake or eating windows. Mild, Gradual Requires planning, Not for everyone. 11 Dietary B3 Foods containing Niacin/Nicotinamide. Minimal Essential for health, Dietary intake alone has limited impact on boosting NAD+.
Ideally, for fatigue, I would combine approaches like something for NAD+ (subq NAD+, oral precursor, whatever), along with peptides/vitamins/supplements/TRT, and a low-dose stimulant for extra "support" as needed.
Regarding tirz fatigue specifically, more calories or carbs (even a daily potato 🥔 or glass of Fairlife chocolate milk) may give a boost (at least over time):
Gah! Can't do it. Do you have a runner up? LOL
www.frontiersin.org
Google Gemini said:
pmc.ncbi.nlm.nih.gov
Capsules are a waste of money, based on the available research. Mots-c, and maybe Semax might a good option.
@Calm Logic beat me to it, but I was going to say, espresso ☺️. We're both in CA, my machine is on.
I just take a 750mg 1x a day, was like 15$ for bottle
Google Gemini said:
Google Gemini said:
I started taking 50mg NAD on Monday and Friday over two weeks ago and it has helped me tremendously. I just bumped up to 75mg my last pin. I actually feel awake during the day now. It doesn’t affect my sleep I can still definitely take a nap during the day if I try but the NAD I feel has really helped me be a functional human again 🤣
Could be the NAD, I definitely felt really sleepy from it, until I made sure I took TMG. And what is zip fizz?
Got some on the way, thanks 🙏
Hey Andy! Do you use L-carnitine? I see a lot of local brands here in India selling L-carnitine - 1000mg/5ml injections, But its written on the packaging that its for IV use. Can this be used for IM or do people get it separately for IM?
I do not. I tried it and had bad reactions. There are people here who do and there is a thread dedicated to it.
Thank you! Will search for it
