NAD+ for fatigue?

[cmath]

Tirz seems to be depleting my energy quite a bit. I'm doing all the things like protein and water and exercising, etc. Does anyone have any success with NAD + either capsule or SQ? Open to other suggestions as well

 

[Calm Logic]

For some people at least, MOTS-c has more energy/feelz. But I haven't tried anything for energy yet.

 

[AndyPanda]

Tirz seems to be depleting my energy quite a bit. I'm doing all the things like protein and water and exercising, etc. Does anyone have any success with NAD + either capsule or SQ? Open to other suggestions as well

I have two cents! NAD+ has low bioavailability in the oral form. Subcutaneous is better, but infusion is the best. Some people swear by NAD+, while others don’t feel anything. Because it is a little pricey, I would suggest that you try a B-Complex injection first. Something like NEUROBION, or Polibion/Polybcon that is $0.50 or less per IM injection. B3 (nicotinamide) is a precursor to NAD+ anyway and with a lot of these peptides and supplements you won’t feel much of anything unless it is something you are deficient in. I think it’s why so many people go for Clenbutetol or stimulants. It isn’t natural and you can feel it working.

 

[Calm Logic]

Below is a table from Google (Gemini). It may be horribly wrong (had to correct it twice already), but the general idea I get is that NAD+ subq looks like it may be worth the greater cost (depending on age, tolerance to oral stimulants like clen, etc). Or trying oral NR supplements (or oral NAD+ and NMN (NMNH)), like on Amazon.

Rank	Method	Description	Potential NAD+ Impact	Key Considerations
1	NAD+ IV Therapy	Direct infusion into bloodstream.	Highest, Rapid	Medical procedure, Costly, Limited long-term data.
2	NAD+ Subq Injection	Injection under the skin.	Significant, Relatively Rapid	Requires sterile technique, Less human research than oral, Potential site reactions.
3	NR Supplements	Oral NAD+ precursor, well-studied.	Significant	Oral, Good bioavailability, Quality control important.
4	Oral NAD+ Supplements	Direct oral NAD+ delivery.	Potentially Significant (bioavailability dependent)	Oral, Bioavailability research ongoing, May require specific formulations for better absorption.
5	NMN Supplements	Oral NAD+ precursor, promising research.	Significant	Oral, Bioavailability research ongoing, Quality control important.
6	NMN Subq Injection	Injection of NMN under the skin.	Potentially Significant, May have better bioavailability than oral NMN	Requires sterile technique, Less human research than oral NMN/NR, Dosage protocols evolving.
7	High-Dose NAM	Oral Vitamin B3 precursor, high doses can inhibit sirtuins.	Moderate	Oral, Lower cost, High doses may have negative effects.
8	Sirtuin Activators	Compounds like Resveratrol, enhance NAD+ effects.	Indirect	Often dietary, Bioavailability varies, Efficacy under investigation.
9	Exercise	Regular physical activity.	Mild, Gradual	Numerous other health benefits, Sustainable.
10	Caloric Restriction/IF	Reduced calorie intake or eating windows.	Mild, Gradual	Requires planning, Not for everyone.
11	Dietary B3	Foods containing Niacin/Nicotinamide.	Minimal	Essential for health, Dietary intake alone has limited impact on boosting NAD+.

Ideally, I would combine approaches like something for NAD+ (subq NAD+, oral precursor, whatever), along with peptides/vitamins/supplements/TRT, and a low-dose stimulant for extra "support" as needed.