Re microdosing: I'm pretty sure I'm spinning my wheels and wasting product to cater to my cautious nature and we'll be going up in our dosage next (3rd) week... probably up it to 1mg for a couple of weeks, reevaluate and move to 2mg (the starting trial dose) for the next month.
This video kind of explains my thought process.
How To Properly Dose Retatrutide (And Why Microdosing Doesn't Work)
Watching that, he compares 2mg/week to .1mg/day. I'm still working my way through it, but he seems to be conflating micro dosing and split dosing.
He compares 2mg/week to .7mg/week, and says it "kinda sounds like you might be getting close to the same amount, right? Wrong." Who thinks that .7mg/week sounds the same as 2mg/week?
I don't know where he gets 2mg/week creates a "consistent amount in your system, about 3.6mg on average". It peaks at 3.6mg, troughs at 1.6mg, and averages 2.5mg.
Using what I think is his math (bolus, all instantly available vs a 24 hour absorption window, for example):
-If you take the 1mg twice a week, you end up with a peak of 3mg, trough of 2mg, and average of 2.5mg.
-If you take .285mg daily, the peak is 2.62mg, trough is 2.33mg, and the average is still 2.5mg.
-If you take 4mg every other week, the peak is 5mg, the trough is 1mg, and the average is still 2.5mg.
I agree that you need a minimum effective dose and half lives stack. Taking the same amount per week, split into multiple injections raises troughs and suppresses peaks, creating a tighter band of exposure/signaling (less variability).
Average amount is relatively irrelevant, otherwise we could take a dose once every 4 weeks (for example) and radically reduce the pin cushion effect. The problem with this is the symptoms would likely be massive, receptors could be blunted, and the adjustment window is very coarse. The way I think about it is peaks trigger symptoms and troughs need to be high enough to be therapeutically effective. Split dosing can reduce symptoms and keep the floor high enough to work.
