New year new me

I struggle to sleep more than 5 hours at a stretch and haven't noticed any major changes at 3 weeks in but I'm hopeful.
 
woundcarping said:
I haven't noticed sleep benefits I attribute to Reta, but I am sleeping longer/better with the addition of 360mg of supplemental magnesium.
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I've been chewing a 250mg magnesium citrate gummy in the morning, is that in the ballpark?
 
I started with tirz and my sleep definitely improved. I've now experienced the same on reta. I just wanted to mention to remember that it's not a race to lose the weight, and 5 lbs. per week is extreme (after your initial water shed). Be careful not to overdo it and remember to eat and prioritize protein, electrolytes, and hydration. Otherwise, sounds like you are doing great!
 
I take fiber daily with my first protein shake. No issues with plumbing on GLP; I actually reduced my supplemental fiber to a third after starting mag glycinate.


I started taking glycinate specifically for the (alleged) benefit to sleep, the nervous system, and cramp reduction (not a big issue but it was on the radar).

I didn't start tracking sleep until after I started taking glycinate.
 
My system seems to be too sensitive to fiber types of anti-constipation relief, can't find the line between all or nothing. I'll try adding glycinate to the mix instead of another fiber pill and see if that gets me in the ballpark. Thank you.
 
My fiber is PHGG.

Glycinate can be osmotic, but its primary uses typically don't include constipation.

Drink plenty of water and get some steps in, both help keep things flowing.

"Anti-Constipation Relief" sounds like you need Imodium 🤣
 
TirzCore said:
I started with tirz and my sleep definitely improved. I've now experienced the same on reta. I just wanted to mention to remember that it's not a race to lose the weight, and 5 lbs. per week is extreme (after your initial water shed). Be careful not to overdo it and remember to eat and prioritize protein, electrolytes, and hydration. Otherwise, sounds like you are doing great!
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Well said, I lost 4 the first week. Basically stayed the same 2 and 3 and then week 4 lost another. 4 pounds 4 weeks. I'm happy. This week I notice that my food noise came back earlier in the week. Next week I'm going to jump to 1mg.
 
woundcarping said:
Watching that, he compares 2mg/week to .1mg/day. I'm still working my way through it, but he seems to be conflating micro dosing and split dosing.

He compares 2mg/week to .7mg/week, and says it "kinda sounds like you might be getting close to the same amount, right? Wrong." Who thinks that .7mg/week sounds the same as 2mg/week?

I don't know where he gets 2mg/week creates a "consistent amount in your system, about 3.6mg on average". It peaks at 3.6mg, troughs at 1.6mg, and averages 2.5mg.

Using what I think is his math (bolus, all instantly available vs a 24 hour absorption window, for example):
-If you take the 1mg twice a week, you end up with a peak of 3mg, trough of 2mg, and average of 2.5mg.
-If you take .285mg daily, the peak is 2.62mg, trough is 2.33mg, and the average is still 2.5mg.
-If you take 4mg every other week, the peak is 5mg, the trough is 1mg, and the average is still 2.5mg.

I agree that you need a minimum effective dose and half lives stack. Taking the same amount per week, split into multiple injections raises troughs and suppresses peaks, creating a tighter band of exposure/signaling (less variability).

Average amount is relatively irrelevant, otherwise we could take a dose once every 4 weeks (for example) and radically reduce the pin cushion effect. The problem with this is the symptoms would likely be massive, receptors could be blunted, and the adjustment window is very coarse. The way I think about it is peaks trigger symptoms and troughs need to be high enough to be therapeutically effective. Split dosing can reduce symptoms and keep the floor high enough to work.
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Thank you, you caught his error. This makes more sense for minimizing the peaks and troughs. I had to run it through the plotter so I could visualize it. 😆
We're on week 4 of .5mg of Reta and have comfortably lost around 2 lbs a week with low sides but appetite increases around day 4 post injection. At this point my plan is when we increase to go to a twice a week dose of .5 for the gentler ride.
 
RetCurious said:
Thank you, you caught his error. This makes more sense for minimizing the peaks and troughs. I had to run it through the plotter so I could visualize it. 😆
We're on week 4 of .5mg of Reta and have comfortably lost around 2 lbs a week with low sides but appetite increases around day 4 post injection. At this point my plan is when we increase to go to a twice a week dose of .5 for the gentler ride.
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That's great on such a low dose. My understanding is Reta at those low doses is functionally similar Tirz, the GCGR signaling is well below the typical threshold for it to enable the metabolic benefits.

I started on Zepbound at 2.5mg, week 3 I took my regular injection, food noise came back mid week, so I took my 4th 2.5mg dose on 12/29 and started my split dosing journey there... it just made sense from what I was experiencing and had learned along the way. My plan on Tirz was to stay at the minimum effective dose which I defined as keeping appetite managed and food noise gone.

Since 1/10, I've split dosed the heck outta Reta (13 pins) to get my levels up while negating sides and coming off Tire. I've dropped 12lbs since 1/10 for a total of 22lb lost since the 12/10 start. My minimum effective dose on Reta being defined as no food noise, controlled appetite (not entirely flattened), and GCGR meaningfully signaled, which is typically ~6-8mg/week it based on what I've learned.

My current cumulative exposure (Shotsy is well worth it to me with calculating all the smaller doses) is around around the peak of a steady state 5.5mg/weekly dose, 9.8mg. Tuesday is likely my next Reta dose, and I'll either keep the same peak I had now (4mg first thing in the morning), or push it up to 6mg/weekly dose's peak (6mg that evening). From there I'll probably be down to roughly 2 doses a week, being at the minimum effective level and letting my steady state normalize.

This uses my assumptions of a 6 day half life, 24 hours from injection to peak, first order elimination. Might be helpful for someone.
1769887704405.webp
 
Latest weigh in ( this morning) has me at 212 down 7 pounds. Felt the food noise early in the week, didn't give in and saw the biggest drop in weight this week. Was going from .5 to 1 when I pin later tonight but really debating staying at .5 since it's obviously still working. Anyone see a reason to jump to 1 ??
 
weightlossking84 said:
Latest weigh in ( this morning) has me at 212 down 7 pounds. Felt the food noise early in the week, didn't give in and saw the biggest drop in weight this week. Was going from .5 to 1 when I pin later tonight but really debating staying at .5 since it's obviously still working. Anyone see a reason to jump to 1 ??
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I'm obviously no expert but I am in the same boat, I was thinking of going up on a biweekly basis to cut the food noise. I'm down 9 lbs 3 days into week 4.
 
Dose escalation going .5mg to 1mg seems entirely up to you, same with split dosing. No trials tested either methodology, but neither or both seem remotely risky or aggressive.
 
weightlossking84 said:
Latest weigh in ( this morning) has me at 212 down 7 pounds. Felt the food noise early in the week, didn't give in and saw the biggest drop in weight this week. Was going from .5 to 1 when I pin later tonight but really debating staying at .5 since it's obviously still working. Anyone see a reason to jump to 1 ??
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I started at 1 mg and just began week 5. I’m still losing weight at this dose, so I don’t see any reason to move up until it stops working for me. I also feel that losing a lot of weight too fast can lead to extra skin, so going slow works better for me.
 
Just a quick check in... 5 weeks in and still at .5mg. Didn't feel the need to go to 1 just yet. Total loss is 7 pounds. Food noise definitely creeps in earlier in the week then when I started but I have been so busy I'm able to push it aside. Sleeping better then I ever have. Only side effect would be dry mouth but there's enough salt on these NYC streets that could be causing that as well. Bowel movements have been so so but I think it's due to eating healthier. Have been keeping up in the gym and honestly overall feel great.
 
Retatrutide is the only GLP peptide that showed really quite good, but a bit surprising effectiveness at low doses. About 9% average weight loss at 1mg per week over about a year. Tirzepatide and semaglutide have not shown anywhere near that level of effectiveness at low doses. It seems to be working exactly like that in weightlossking84.
I would guess you will find someone who says that some peptides help with stretch marks, but I would be surprised if any actually did. If they are newer and darker or red then they usually fade to skin colour eventually , but they are essentially scars so do not really go away.
 
Newest weight in. Down another pound a half. Enjoyed 3 beers and a nice sandwich while watching the game. Haven't focused on calories, just eating fairly clean, lots of water, electrolytes and exercise. Debating a jump to .75 or even 1mg but at the same time 5 weeks in the .5 is doing the job.
 
Weekly update... .75 mg for the 2nd week in a row. Totally forgot to weigh myself yesterday due to being super busy. At this point #s are nice but I notice how I feel and how my clothes fit so much better. People have made comments at work so I know it's working. Slow and steady. Ate slightly unhealthy this weekend and probably had too many drinks but a guys gotta live right ? For me it isn't some magic overnight pill but a tool that's helping me on this journey. As always open for any questions/comments.
 
weightlossking84 said:
Weekly update... .75 mg for the 2nd week in a row. Totally forgot to weigh myself yesterday due to being super busy. At this point #s are nice but I notice how I feel and how my clothes fit so much better. People have made comments at work so I know it's working. Slow and steady. Ate slightly unhealthy this weekend and probably had too many drinks but a guys gotta live right ? For me it isn't some magic overnight pill but a tool that's helping me on this journey. As always open for any questions/comments.
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FYI for people just starting to follow my first 5 weeks were .5 and went to .75 for 6 and 7
 
weightlossking84 said:
FYI for people just starting to follow my first 5 weeks were .5 and went to .75 for 6 and 7
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I went to .5mg 2X a week w/ a 3 day off set on week 5. This got rid of the hunger and appetite issues I was experiencing at the end of the 7 day cycle. Added another fiber pill to my routine,
I don't know about you but pulling up these smaller doses are difficult to see for me, I'm not sure I could be accurate on a .75. 😆
 
Jumped on the scale this morning. No movement in my weight but according to my Amazon smart scale ( take it for what it is) I gained muscle and lost fat. In addition I will say for the first time since Jan 4 and my first pin i noticed elevated heart rate before bed. Able to sleep but not the way I have been, had a coffee later then normal but surprised if that's what actually effected me. Was right around the 24-28 hour mark on the pin from monday. Interested to see how tonight goes.
 
7 weeks in and starting yesterday, I had what I would describe as an insatiable appetite. Its almost as of my stomach hurt because I was so incredibly hungry. Odd part is, I don't starve myself in the least. Same feeling today. I had steak broccoli and potatoes for lunch. Protein shake and peanuts as a snack and chicken strips for dinner. I even had oreo's before I started typing this. Anyone ever have this happen or anything similar? 5 weeks at .5 and last two weeks at .75.
 
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