Nexaph testing

[brentm]

I had to ask the oracle about Histidine vs Mannitol excipients.

Histidine​

• Type: Amino acid
• Primary Use: Buffering agent
  • Histidine is commonly used to maintain the pH of a solution within a stable range, particularly in injectable drugs or biologics.
• Advantages:
  • Provides excellent buffering capacity at physiological pH (~6-7).
  • Compatible with many proteins and peptides, minimizing degradation.
  • Reduces oxidative stress in formulations, often protecting sensitive molecules.
• Limitations:
  • Limited solubility at high concentrations.
  • May not provide other stabilizing effects beyond pH control.

---

Mannitol​

• Type: Sugar alcohol (polyol)
• Primary Use: Bulking agent, cryoprotectant, or stabilizer
  • Used in freeze-dried (lyophilized) formulations or as an osmotically active agent in tablets and injectable drugs.
• Advantages:
  • Enhances stability during freeze-drying and long-term storage.
  • Provides structure to lyophilized cakes.
  • Improves isotonicity in parenteral formulations.
• Limitations:
  • Does not act as a buffer; typically combined with a separate buffering agent like histidine.
  • Hygroscopic (absorbs moisture), which can affect stability if not stored properly.

Combination Use​

In some formulations, histidine and mannitol are used together. For instance:

• Histidine serves as the buffer.
• Mannitol provides structural integrity and stabilization, especially in freeze-dried formulations or for long-term storage.

Their complementary roles ensure the drug remains effective, stable, and safe for administration.

 

[spnyc138]

Show me a list of complaints by actual customers, all of these "complaints" are from non customers. Ask these "complainers" for receipts of purchase.

Only been a customer of Nex for a few months now, but what I've received has been fantastic, the service is fantastic. The amount of toxicity towards Cain after reading everything and having my own experience is just silly. I mean is this just other vendors alienating? Yeah yeah...I'm a new account but would be glad to share my social media profiles to show I'm not some alt. If you don't want to use Nex then don't but stop the bullshit exaggerating about them because your life sucks so bad you need to be jaggoff on the internet.

 

[exploitedworkerbee]

Only been a customer of Nex for a few months now, but what I've received has been fantastic, the service is fantastic. The amount of toxicity towards Cain after reading everything and having my own experience is just silly. I mean is this just other vendors alienating? Yeah yeah...I'm a new account but would be glad to share my social media profiles to show I'm not some alt. If you don't want to use Nex then don't but stop the bullshit exaggerating about them because your life sucks so bad you need to be jaggoff on the internet.

Not concerned about the shillery on your first post but walking in calling the forum members jagoffs isn’t the best way to be taken seriously.

Welcome im sure you’re going to fit right in.

 

[Dee X]

Only been a customer of Nex for a few months now, but what I've received has been fantastic, the service is fantastic. The amount of toxicity towards Cain after reading everything and having my own experience is just silly. I mean is this just other vendors alienating? Yeah yeah...I'm a new account but would be glad to share my social media profiles to show I'm not some alt. If you don't want to use Nex then don't but stop the bullshit exaggerating about them because your life sucks so bad you need to be jaggoff on the internet.

What is being exaggerated specifically?

 

[Superchicken1]

@Cain_SPC - while you’re here:
1. Does SNP/SPC finish their own peptides?
2. Does SNP/SPC own the finishing facility?
3. Does SNP/SPC synthesize any peptides?

I asked these questions on your Telegram but got banned.

Did these questions get answered?
@Cain_SPC

 

[DevynL90]

that latest screenshot from SNP's telegram (with cain admitting trying hist w/ reta) sure looks like the smoking gun. if cain decides to no longer reply back at this point, i think we've got our answer folks.

 

[keangkong]

that latest screenshot from SNP's telegram (with cain admitting trying hist w/ reta) sure looks like the smoking gun. if cain decides to no longer reply back at this point, i think we've got our answer folks.

I have never used SNP's products. I can't comment on their quality. However, Cain has established that he cannot be trusted. I am unlikely to ever buy from them.

 

[nccane]

Can cain address why:

1. he went from small moq that were in stock on the website and pre vendor tested

to

2. Mostly prebuys that won't get vendor tested until after the product is received.

This shift in methodology does cause me somewhat concern that nexaph actually does not own a finishing operation or is a manufacturer. Instead, it makes me think nexaph is a reseller who simply has close relationships with suppliers in CN that allow custom orders/wholesale pricing. The only logical reason to do a group buy instead would be cash flow problems. I'm sure the answer will probably be to "dial in supply quantities", but that could easily be done with a poll/survey without getting money upfront.

Most vendors are resellers anyway, so not a big deal in my book. Just looking for the truth.

And yes cain, I am a former and current customer. You know that. Not trying to start a witch hunt. Just curious.

 

[beefsteak]

that latest screenshot from SNP's telegram (with cain admitting trying hist w/ reta) sure looks like the smoking gun. if cain decides to no longer reply back at this point, i think we've got our answer folks.

It all makes sense once you stop believing he's a manufacturer and start believing he's a group buy reseller. He has no idea what goes into his products.

 

[exploitedworkerbee]

It all makes sense once you stop believing he's a manufacturer and start believing he's a group buy reseller. He has no idea what goes into his products.

Not knowing what is in his products is his entire defense against the histidine fiasco, where he said without hesitation that it was in the reta multiple times and then said oooopsy dooopsy lol nm it was just lousy process. Obviously he isn’t in control of the manufacturing.

 

[Cain_SPC]

Can cain address why:

1. he went from small moq that were in stock on the website and pre vendor tested

to

2. Mostly prebuys that won't get vendor tested until after the product is received.

This shift in methodology does cause me somewhat concern that nexaph actually does not own a finishing operation or is a manufacturer. Instead, it makes me think nexaph is a reseller who simply has close relationships with suppliers in CN that allow custom orders/wholesale pricing. The only logical reason to do a group buy instead would be cash flow problems. I'm sure the answer will probably be to "dial in supply quantities", but that could easily be done with a poll/survey without getting money upfront.

Most vendors are resellers anyway, so not a big deal in my book. Just looking for the truth.

And yes cain, I am a former and current customer. You know that. Not trying to start a witch hunt. Just curious.

I've stated multiple times that our production capacity isn't huge and that we are currently in the process of expanding. This is the reason most of the items currently are pre orders. There is a difference between pre orders and group buys. When the product is scheduled to be produced, we open up the pre orders to a certain amount of kits that are being produced, once they run out they run out. I think you have seen the uptick in demand in our products and can understand why we are doing this model instead currently. I don't see this as an issue because we back our products anyways, so if any issues do arise we address them and re ship them.

 

[Cain_SPC]

For the people asking about the Reta histidine:

Yes i assumed at first that it had histidine since when Jano emailed me stating there is an issue with the testing and an unknown filler had been used, i assumed it was histidine since the other samples that were sent in at the same time did have it. This is why i sent in a sample of the histidine to be tested against it. After confirmation from Jano that histidine was not present in the Reta, we went ahead and re produced the batch and sent it out to everyone.

 

[beefsteak]

There's a nice trick to see how much stock he has. Add an in stock product to your cart and set the quantity to 999, it'll automatically adjust to available stock.

His prebuys are infinite stock, so he collects the money and then places the order with whatever chinese vendor he uses. His margins most of the them are less than $100 but more than $50. Probably racking up at least 30k a month flipping chinese peptides.

 

[Cain_SPC]

There's a nice trick to see how much stock he has. Add an in stock product to your cart and set the quantity to 999, it'll automatically adjust to available stock.

His prebuys are infinite stock, so he collects the money and then places the order with whatever chinese vendor he uses. His margins most of the them are less than $100 but more than $50. Probably racking up at least 30k a month flipping chinese peptides.

Yes because doing a pre order and then shipping it out the same week gives me enough time to do all that.

Another non customer that doesn't know what they are talking about.

 

[DwightTheDelight]

There's a nice trick to see how much stock he has. Add an in stock product to your cart and set the quantity to 999, it'll automatically adjust to available stock.

His prebuys are infinite stock, so he collects the money and then places the order with whatever chinese vendor he uses. His margins most of the them are less than $100 but more than $50. Probably racking up at least 30k a month flipping chinese peptides.

I personally don't care about this portion of the argument, because I'd pay a bit more to get what I want easily and quickly. They are good at that.

I'm more concerned with the safety of the batches that were sent out. I apologize if this has been talked about already and I missed it, did we ever figure out what was causing the purity issues of the first batches if histidine wasn't the issue?

 

[beefsteak]

Yes because doing a pre order and then shipping it out the same week gives me enough time to do all that.

Another non customer that doesn't know what they are talking about.

You should have enough liquidity now have stock on hand. The prebuy is just buying time for slow processing times and avoid customer complaints. And international express shipments takes less than 3 days in the event you do exceed your inventory.

 

[MarisWinter]

Only been a customer of Nex for a few months now, but what I've received has been fantastic, the service is fantastic. The amount of toxicity towards Cain after reading everything and having my own experience is just silly. I mean is this just other vendors alienating? Yeah yeah...I'm a new account but would be glad to share my social media profiles to show I'm not some alt. If you don't want to use Nex then don't but stop the bullshit exaggerating about them because your life sucks so bad you need to be jaggoff on the internet.

Thank you.

 

[Cain_SPC]

I personally don't care about this portion of the argument, because I'd pay a bit more to get what I want easily and quickly. They are good at that.

I'm more concerned with the safety of the batches that were sent out. I apologize if this has been talked about already and I missed it, did we ever figure out what was causing the purity issues of the first batches if histidine wasn't the issue?

Most likely it was the actual freeze drying process. The process itself is complicated and if any missteps happen it can cause issues. Issues such as having too much residual moisture in the product.

Either way the old product can be tossed if you are not comfortable using it, the new product that shipped already has the testing available for it via the QR code on the package.

 

[YoYoFat]

Sounds like we're working towards progress.

Cain's response was helpful.

Vendor testing is vendor testing. Usually if they pay for it, it includes the right to change the name on the test to the vendor. I guess the only real gotcha is, if Cain knows who's doing the testing, he could stack the deck to make sure they got good product, and swap out lower quality to the rest of the non-testers.

I think that's the real fly in the ointment, with Cain paying for testing @YoYoFat - it's too easy to stack the deck.

My only other mediation suggestion would be to stop calling Cain/Nexa/Nexaph/SPC the term "baba". It sounds derogatory.

*Only one weasel word was harmed in the making of this message.

Nope. Because he sends the product before we know who’s going to be sending in vials directly to the lab. He can only influence the testing by sending *everyone* good product. And what would be wrong with that? Eh?

 

[Sun&Stars]

IMHO - I'm a 3x customer of Nexa and I'm aware of the history. Cain offers some products as a "pre buy" at a heavily discounted price from other CN or GB sources. The price is increased when they are listed as in stock on the site which is a huge benefit to me. I have my own sheet of trending prices for various peps and sources. Personally, I know if I have an issue of any kind, Cain will work with me towards an acceptable solution. I think it's really a question of personal comfort level for all of us. He has a vested interest in ensuring the safety and efficacy of his products. I think we would be hard pressed to find any of the CN sources (Tracy, Alan, Lisa, Olina, Rebecca, etc.) answering questions Cain has answered. I'm a single mom working harder than an ugly stripper who just wants to be healthy and skinny so be nice y'all