Odd announcement shared by vendor.
- Thread starter mtomm
- Start date
Mr. Blonde
GLP-1 Enthusiast
They looking big picture. The sooner your stash goes bunk the sooner you buy more.
spanky2026
GLP-1 Enthusiast
Huh? That makes no sense.
cheesecake
GLP-1 Apprentice
That is... odd? I understand that UV light and freeze - thaw cycles are bad, but no organic molecule should be impacted by freezing, if sufficiently dry
spanky2026
GLP-1 Enthusiast
Where did you see this? Did they not offer any other info? Weird on so many levels..
BNLFL
GLP-1 Specialist
Where's that stated?
So much bad info lately but that is actually true. To be more specific moving through the peptides glass transition temperature (which can vary slightly) can degrade lyophilized peptides. This is one of the reasons for people buying lower temp freezers on battery backups as well as the original purpose behind the whole hydropeak storage craze.
CNCCurrency
GLP-1 Specialist
Well shit talk about
Ah yes, I was waiting for a random vendor to give me peptide storage advice. I get all of my peptide knowledge and instructions straight from the grey market suppliers I buy from, or don’t buy from…
Unfortunately, they're right.
The Detrimental Effects of Crystalline Excipients: How They Jeopardize the Long-Term Stability of Freeze-Dried Polypeptide Formulations
Gao et al, 2025 Nov
CNCCurrency
GLP-1 Specialist
Most of those are proteins, so?
No, they explicitly focused their research on understanding what happens with peptides like sema and tirz. Their research model is based on insulin and glucagon. I think this is to prevent the results from being influenced by the hydrophobic chain of tirz/sema.
Airborne Daddy
GLP-1 Specialist
Same asshats cant post product or price. Join our telegram and send 500 to our btc address well later claim was a scammer that jumped on the page. I put the bride on 18 month frozen SSA tirz and shes down 26lbs in 9 weeks.
Last edited:
WeezinDaJuice
GLP-1 Enthusiast
Can I have your address and trash pickup day?
RetCurious
GLP-1 Enthusiast
Sounds like half baked goods to me. Folks chasing the lowest prices are getting exactly what they're paying for.
"A well-formulated lyophilized peptide with appropriate excipients and less than 1-2% residual moisture typically has a Tg well above room temperature, ensuring stability at -20°C with a substantial safety margin."
Temperature Effects on Peptides: Thermal Degradation, Cold Chain, and Storage Optimization
Temperature effects on peptides: Arrhenius kinetics, glass transition, freeze-thaw damage, cold chain, and storage protocols.
HereKittyKitty
GLP-1 Enthusiast
Simplify it for me, please. Are we now not freezing for storage?
Flash-BCR
GLP-1 Apprentice
Well, if we aren't I've got a 8lb pot roast and a couple bags of frozen hash browns sitting on top of my pep bag at the bottom of the freezer...might be a few weeks before I can dig them out...in the mean time.....FOLLOWING
randompersonrandom
GLP-1 Specialist
I'm happy for her! Everything I've ever heard about her makes me think she and I would be friends.
sheilarae74
GLP-1 Enthusiast
This is another reason I am hesitant to buy more than two years of anything. I always see conflicting info about freezer temps, storage protocols and time.
Flash-BCR
GLP-1 Apprentice
My strategy (based on freezer claims) has targeted 8-10 years worth...but realistically, I am at an age that my excess supply will become part of my estate that the kids fight over... 😎 👍
I mean I don't personally worry about it but I've seen the study where it can be an (admittedly minor) issue with common freezer temperature swings. Especially "frost free" freezers. Which will go above -20C (-4) on a regular basis. This cyclying is what causes the most degradation, at least that was what I understood.Sounds like half baked goods to me. Folks chasing the lowest prices are getting exactly what they're paying for.
"A well-formulated lyophilized peptide with appropriate excipients and less than 1-2% residual moisture typically has a Tg well above room temperature, ensuring stability at -20°C with a substantial safety margin."
Temperature Effects on Peptides: Thermal Degradation, Cold Chain, and Storage Optimization
Temperature effects on peptides: Arrhenius kinetics, glass transition, freeze-thaw damage, cold chain, and storage protocols.aminocoreresearch.com
Do I worry at all about this? No. I toss my kits in the garage freezer and don't think about it.
RetCurious
GLP-1 Enthusiast
I, on the other hand, have spent the last hour or so querying Claude about my stash's TG. 😅
I am thinking that I'll hold off on any new purchases until I work through most of what I have. Fresh is good.
I am thinking that I'll hold off on any new purchases until I work through most of what I have. Fresh is good.
Last edited:
5byfive
GLP-1 Enthusiast
Did y'all read the paper? Where does it say that freezing caused the problem? I'm not seeing that. It is talking about degradation despite freezing and what compounds are more protective. The paper suggests that freezing might not be enough to maintain long term stability but not that causes a problem. It also goes against a lot of other research and common lab practices. It suggests there could be an issue with long term storage but I don't know that it is conclusive.
2 things to consider. This would only be a problem if the vial does not have proper vacuum which would in turn leave too much moisture in the product which would lead to degradation when frozen. The other would be the vendor could use it as an excuse when selling you an inferior product, and then blame it on the practice of freezing, which most of us do. Either way, they're just covering their ass!
MikeyMike
GLP-1 Apprentice
This does not address the effect of freezing freeze dried peptides. This is examining the effect of crystalline excipients.
All the literature out supports freezing lyophilized peptides at -20C. Peter Majic also discusses this in several videos when asked about storing peptides long term.
spanky2026
GLP-1 Enthusiast
Yeah, Peter's video basically makes the case for them being damn near indestructible.
