Once you meet your goal - Cycle off or find a maintenance amount and cruise...

gimmeshelter

GLP-1 Enthusiast
Member Since
Feb 22, 2026
Posts
201
Likes Received
341
Location
NC
United-States
I am just curious with those that have met the weight goal they had in mind. For example, you went from 200lbs to 165lbs. Once you get to 165lbs are some lowering the dosage but staying on a schedule or do you cycle off and then back on as needed?

For those that find a maintenance number is it near the amount you started at? Below? Above? Thanks !
 
In the past I have cycled off, so as not to become dependant on exogenous molecules. I've only ever had 10-15 lbs creep back in times of inadequate diet/exercise/stress, and deal with it accordingly with another short cycle.

I find the best maintenance number is not so much a number, but where your body can comfortably sit without excessive effort. To me, too much maintenance effort is a sign that the goals are unsustainable. The lower the body fat the harder it is to maintain without rigorous diet/exercise, and then you have the hormonal BS that goes with it, chronically high cortisol, loss of hair, loss of menses (for women).

What about you? What's your take on it?
 
I'll tell you in 6 months. Folks I know, including my Dr. cycled off and only pin when needed. (seldom)
Whoops! Just noticed this is in the Reta group. N/M
 
I'm currently trying to find equilibrium. I'm extending time between doses while also tweaking my dose. Currently at 2.2mg/5days. Will continue to adjust as necessary. I don't plan on attempting to discontinue use.
 
I am just curious with those that have met the weight goal they had in mind. For example, you went from 200lbs to 165lbs. Once you get to 165lbs are some lowering the dosage but staying on a schedule or do you cycle off and then back on as needed?

For those that find a maintenance number is it near the amount you started at? Below? Above? Thanks !
Been in "maintenance" for 6 months. I have yet to find the sweet spot of doseages and frequency. I was on tirz for 2 years went from 255 down to 190. I never went above 5mg .. I responded well to the low dose. Currently doing 2.5 every 5 days, but still playing with it. I have not gained more than a few pounds but have been able to lose it back. I dont think ill ever stop being on a glp. Everyone responds differently and depending what glp your taking or if your stacking your "maintenance" will be a process until you are comfortable of where your at.
 
This is a metabolic optimizing drug, I won't be cycling off. My A1c is on point, my fasting insulin stays low, my egfr is the highest it's ever been. I'm at goal. Some luckier people have been able to reduce dosage to maintain , but I haven't been one of those people.
 
I figure the dose that got me there is probably the dose that'll keep me there. I just did what I hope will be my last increase (to 9mg) and I've only got six pounds to go.

I DO plan to stop the survo, though. I really only started doing it to fight tirz fatigue, and I suspect that after six months, I may not have it anymore. Or I may never have had it at all and just thought I did and was just tired because I wasn't eating enough to support my then-bigger body comfortably. Plus, because all my compulsive nature vanishing overnight meant that until my brain adjusted, I didn't have compelling reason to do anything but sit on the couch. But my brain adjusted to being able to feel motivation, and I'm pretty sure when I stop the survo, I won't get tired again
 
Even if I was not trying to keep off more than half my bodyweight, I would be staying on it forever to prevent heart attacks, stroke, heart failure, diabetes and probably cancer. I am likely to be at above average risk, but so are a very high percentage of people who have had obesity long term.
 
The lesson from SURMOUNT-4:

"The consistency of these data across therapeutic classes... suggests that obesity is a chronic metabolic condition...requiring long-term therapy in most patients. Much of [the] initial improvement in cardiometabolic risk factors had been reversed [after stopping tirzepatide]."
 
Last edited:
For people who have or had severe long term obesity, and lost the weight using GLP's, stopping it after losing the weight is pretty much wishful thinking. By all means try, especially if you have better eating and exercise patterns, but I think it would be important to restart it sooner rather than later if weight started increasing , otherwise you are basically back to yo yo dieting, which if you stay on them you may never need to do again. I strongly agree with the comment above that if it takes constant mental effort to keep the weight off by eating less than your body tells you to, it is not really sustainable, almost everyone will run out of that sort of effortful mental energy eventually.
For people who are not in this category, ( less severe obesity or more recent ) it is not quite as straightforward , although I think the same issues apply in the end. Putting back on 10 or even 20 kg is not great for health but not anywhere near as destructive as bmi's in the 40's or more. The biggest advantage of GLP drugs is that you can keep the weight off. It does make it a bit easier to lose the weight in the first place, but almost everyone who has any kind of weight problem will have lost some weight successfully at some point, it really is not the hard part. The hard part is months or years after, still having to resist eating things you want to eat, if you do not want to regain the weight. And doing this when stressed or upset or at Christmas or on holidays etc. GLP drugs essentially solve the problem, given that in this weight range they are good enough to get to healthy body weights or non overweight BMI's, and it does not require that constant forever mental effort, just keep taking the GLP, and from what is currently known but not yet proven in healthy populations, they are likely to make you live a longer healthier life. Assuming side effects are not a problem, it really is a no brainer, and if you do not stay on them and put weight back on the chances are you will end up needing blood pressure pills and statins and maybe anti diabetes medications in the long term anyway so you do not necessarily escape relying on medication either way.
 
Most people probably won't be able to maintain the weight loss, hence here we are with the GLP1's and probably needing some sort of small dose to be compliant. Me included! I have found 1mg Reta & 1-1.5mg Tirz to work pretty well for me, keeping the Demons at bay. I fought this all my life (like most people) I'm down about 400lbs, between weight loss surgery and the help of a GLP-1. It takes about 6 weeks for it to leave your system, I've done this 3X and gained some weight right back like I'm a Rock Star and have to go back in rehab! (I'll say hi to Lyndsey Lohan for us) Honestly still makes me feel like a bit of a disappointment. Sooo

Glasses Why Dont We Have Both GIF by nounish ⌐◨-◨
shut up and take my money GIF
 
This is a metabolic optimizing drug, I won't be cycling off. My A1c is on point, my fasting insulin stays low, my egfr is the highest it's ever been. I'm at goal. Some luckier people have been able to reduce dosage to maintain , but I haven't been one of those people.
I, too, began using primarily for metabolic health. Had bloodwork done 12/28/25, began Reta the next day. Bloodwork done on 2/23/26 showed 0.2 drop in A1C, total cholesterol dropped 8%, triglycerides dropped 28%, HDL which was already great rose 5% to 96(!), and my LDL reduced by 30%. As I experiment for a few months with Tirz, I think I'm in for life (figuratively and literally.)
 
Honestly still makes me feel like a bit of a disappointment. Sooo

I don't feel like a disappointment at all. I knew going in that if these drugs worked for me, then it was likely that I'd have to keep taking them for them to keep working for me. I didn't even know about SURMOUNT, but it just seemed like common sense. If bp meds only bring your bp down as long as you keep taking them, and statins only keep your cholesterol down as long as you keep taking them, and ADHD meds only keep you able to funciton as long as you keep taking them, then why on earth would I expect that "don't be overweight" meds would keep working without me having to keep taking them?

I don't have time to hand wring about whether I should feel bad for needing these meds to keep the weight off because I'm buying shirts that don't hide the lines of my waist, because I paid too much money for this waist and waited too long for it to come into existence to throw it into shirts that hang down from my bust and make me look like a tank.
 
My non scientific theory is if you were metabolically broken you'll probably be a lifer. If you just over ate and needed some will power help you could cycle off. I lost the same 5-10lbs with diet and exercise and now have lost almost 20lbs with close to same diet and exercise I was doing before Reta.🤷🏻‍♀️
 
I don't feel like a disappointment at all. I knew going in that if these drugs worked for me, then it was likely that I'd have to keep taking them for them to keep working for me. I didn't even know about SURMOUNT, but it just seemed like common sense. If bp meds only bring your bp down as long as you keep taking them, and statins only keep your cholesterol down as long as you keep taking them, and ADHD meds only keep you able to funciton as long as you keep taking them, then why on earth would I expect that "don't be overweight" meds would keep working without me having to keep taking them?

I don't have time to hand wring about whether I should feel bad for needing these meds to keep the weight off because I'm buying shirts that don't hide the lines of my waist, because I paid too much money for this waist and waited too long for it to come into existence to throw it into shirts that hang down from my bust and make me look like a tank.
I get what you're saying 110% and appreciate it. I'm old, lifetime of bullying, parents not wanting a huge child, body dysmorphia, etc! It was always hard work, move more, eat less etc. I have worked in production all my life, been on my feet all my life and it's been hard to come down off that shelf and except that I can't do it by myself. The weight loss surgery was 17 years ago, after regaining 150lbs 14 years later and I needed help again. I've had 13 surgeries, 2 more this year and a few more in my future. Mostly Orthopedic, being in pain everyday and trying to stay out of a nursing home. I'm just being honest with myself, trying function while I can and hoping peptides can help limp along into retirement or disability (whichever hits 1st)

Maybe that's a little too much or too real or sounds exaggerated, I'm on the slow fast track and I think if I don't feel like this. I'll lose the fight!
 
Maybe that's a little too much or too real or sounds exaggerated, I'm on the slow fast track and I think if I don't feel like this. I'll lose the fight!

Oh no, no shade or scorn at all--and my experience isn't yours, and doesn't cancel it or is at all intended to invalidate it. I only hope to be able to pass you some of my refusal to bully MYSELF, the rest of the world can try it if they want to, but I won't help them by saying their mean shit in my head to myself.
 
In the past I have cycled off, so as not to become dependant on exogenous molecules. I've only ever had 10-15 lbs creep back in times of inadequate diet/exercise/stress, and deal with it accordingly with another short cycle.

I find the best maintenance number is not so much a number, but where your body can comfortably sit without excessive effort. To me, too much maintenance effort is a sign that the goals are unsustainable. The lower the body fat the harder it is to maintain without rigorous diet/exercise, and then you have the hormonal BS that goes with it, chronically high cortisol, loss of hair, loss of menses (for women).

What about you? What's your take on it?
Hoping to meet goal and lifestyle change makes it stick, we shall see but it is def something I am already thinking about as I start my journey.
 
I am just curious with those that have met the weight goal they had in mind. For example, you went from 200lbs to 165lbs. Once you get to 165lbs are some lowering the dosage but staying on a schedule or do you cycle off and then back on as needed?

For those that find a maintenance number is it near the amount you started at? Below? Above? Thanks !
Excellent question... I was thinkin about starting a thread asking for info as to maintenance dose/ frequency of Tirz but curios of other GLP's also. I'm nowhere near going maintenance yet...
 
Hoping to meet goal and lifestyle change makes it stick, we shall see but it is def something I am already thinking about as I start my journey.
It really can stick, even if we have metabolic or autoimmune issues that make it more difficult for pudge to budge. I lost 70 lbs 26 years ago (the old WeightWatchers way) and have kept it off ever since.

When I do gain, its only ever 10 to 15 lbs, and it's only happened twice in the two plus decades since. Those were times when indulgence increased, fitness decreased, and self care went out the window (stress + holidays + breakups = 😵‍💫).

You really do work on yourself, inside and out. You learn your patterns and consciously work to change them (like going to the fridge when bored or stressed). You learn to love and respect yourself, and change your entire lifestyle. It's possible, and it's glorious.

The better you feel in your body, the better you start to treat yourself, and you decide not to hurt yourself anymore. It takes time, but it can stick. 🙂
 
The lesson from SURMOUNT-4:

"The consistency of these data across therapeutic classes... suggests that obesity is a chronic metabolic condition...requiring long-term therapy in most patients. Much of [the] initial improvement in cardiometabolic risk factors had been reversed [after stopping tirzepatide]."
I dunno, Calm. Did you read the conflicts of interest and study funding? If I or my shareholders made money off of you buying it for life, I'd tell you to stay on it too.
 
I dunno, Calm. Did you read the conflicts of interest and study funding? If I or my shareholders made money off of you buying it for life, I'd tell you to stay on it too.
Well, good luck to you. It's painfully obvious to me.
 
I dunno, Calm. Did you read the conflicts of interest and study funding? If I or my shareholders made money off of you buying it for life, I'd tell you to stay on it too.
This. Just like you need to be on that ridiculous titration schedule..
I will see for myself. I may be happiest doing exactly what I'm doing now forever, who knows.
 
If I had more control of my home food environment, I would possibly never have needed GLPs, but it's hard to know with getting older, etc. I was of normal BMI until after I got married at age 35. I never bought mayonnaise and rarely chips, and never donuts or brownie mix.

My lean spouse has a mean sweet tooth, and there is an 870-calore slice of carrot cake on the counter now. With GLPs, I may have a bite or two at the most. Without GLPs, God help me, even with putting temptations out of the way.

Each family kitchen can be a microcosm of our society's food environment as a whole, with the commercials for Papa John's new pan pizza keeping the mental marathons going.
 
Last edited:
If I had more control of my home food environment, I would possibly never have needed GLPs, but it's hard to know with getting older, etc. I was of normal BMI until after I got married at age 35. I never bought mayonnaise and rarely chips, and never donuts or brownie mix.

My lean spouse has a mean sweet tooth, and there is an 870-calore slice of carrot cake on the counter now. With GLPs, I may have a bite or two at the most. Without GLPs, God help me, even with putting temptations out of the way.

Each family kitchen can be a microcosm of our society's food environment as a whole, with the commercials for Papa John's new pan pizza keeping the mental marathons going.
SAME. I am fine on my own, but my family wants chips, appetizers, deserts... and it's Everywhere!
I agree with you. I didn't know what was meant by food noise; until it was GONE!
 
It really can stick, even if we have metabolic or autoimmune issues that make it more difficult for pudge to budge. I lost 70 lbs 26 years ago (the old WeightWatchers way) and have kept it off ever since.

When I do gain, its only ever 10 to 15 lbs, and it's only happened twice in the two plus decades since. Those were times when indulgence increased, fitness decreased, and self care went out the window (stress + holidays + breakups = 😵‍💫).

You really do work on yourself, inside and out. You learn your patterns and consciously work to change them (like going to the fridge when bored or stressed). You learn to love and respect yourself, and change your entire lifestyle. It's possible, and it's glorious.

The better you feel in your body, the better you start to treat yourself, and you decide not to hurt yourself anymore. It takes time, but it can stick. 🙂
Congratulations on having lost weight and kept it off in the pre GLP era. It is certainly something I tried very hard to achieve and failed to do, best ever was getting to normal BMI and staying there for nearly 3 years then putting weight back on and ending up at 145kg about 8 years later. Every bit of research I have ever read says that while it can be done, it is genuinely rare, with only around 5% of people who achieve massive weight loss through diet and exercise keeping the weight off long term.
For most people with significant obesity and especially those with health problems associated with obesity, staying on them long term for weight maintenance and added heath benefits are a better option than stopping them. Most people who have lost a lot of weight who stop them will either end up regaining weight or restarting the GLP's or both.
In most or all people with severe obesity who lose lots of weight there are processes occurring that make keeping the weight off hard. With weight loss hunger increases, and metabolic rate decreases. While obese metabolic rate is above normal usually due to extra lean and fat mass and the extra energy required to move that extra mass around. With massive weight loss this falls to normal as extra mass is lost and then metabolic adaptation reduces daily energy expenditure to below levels that would be usual for someone of that weight, age and activity level. So that to maintain the weight loss calorie intake has to be lower than average, despite the increased hunger, and this problem continues for years or possibly forever. Maintaining this requires mental effort and in nearly everyone this eventually is exhausted and weight regain occurs as food intake increases.
I only started GLP's for maintenance.
I have the fairly recent experience of losing 70kg or so without GLP medication, and staying there for a year. At that point as far as I knew the costs were just not viable for me. Eventually I worked out that there was a reasonably inexpensive legit option for ozempic in Australia and started that. The difference in maintaining that weight loss with and without GLP medication is huge, even with low dose ozempic it was worth putting up with the nausea and malaise for a year in exchange for less hunger. And once I discovered grey GLP's , they made a much bigger difference as I was able to tolerate normal doses of tirzepatide, and added a bit of retatrutide as well to increase the effect.
Trying to keep the weight off without GLP's I was constantly worried that I would mess up and eat the wrong foods or start putting on weight and did not really believe I would be able to keep it off long term, as that is what had happened every time in the past. And was hungry a lot of the time. This was despite daily exercise and a very healthy diet.
With GLP medication I have reasonable confidence the weight will stay off. And life is more pleasant without the near constant hunger and fears of triggering excessive eating. I am asking a lot more than the studies have shown in getting them to assist in keeping off a weight loss of 54%, but so far it seems to be working.
For most people staying on GLP's after the weight loss improves people chances of maintaining healthier lifestyle choices. Several studies have shown people buy and eat healthier, less processed, lower fat and sugar foods while taking them. And exercise is easier, more pleasant and less likely to cause injuries or long term joint damage at lower weights, increasing odds of continuing exercise by preventing weight regain. For most of the population cost is a major factor on staying on them long term. The price for grey GLP's is so low at 25c/mg for tirzepatide and around 50c/mg for retatrutide that this is a non issue even for fairly poor people.
 
I am just curious with those that have met the weight goal they had in mind. For example, you went from 200lbs to 165lbs. Once you get to 165lbs are some lowering the dosage but staying on a schedule or do you cycle off and then back on as needed?

For those that find a maintenance number is it near the amount you started at? Below? Above? Thanks !
From a starting weight of 232.6 lbs on June 6, 25 (I lost 10 lbs prior from 245 with willpower alone and it sucked), I met my original goal weight (190) October of last year annd then proceeded to take another 5 lbs off for good measure. October of last year I was on 7.5 mg of tirz and 1.8 mg of survo and have stayed on that regimen ever since. I haven't gone above 190 since then and average 187.5 for months now. I eat whatever I want when I want (which admittedly is vastly different and healthier than pre-June 2025) and I do finally enjoy exercising and - believe it or not - walking - especially stairs. I still get a big kick out of being able to do stairs without being completely wiped. Grey glps are dirt cheap and I see no reason whatsoever to judge myself for taking care of myself or believing the old moral effort and backbone bullcrap regarding will power and weakness and character-deficit. What a waste of time, energy, and emotion to think that I have anything at all to prove. To who? For what purpose? Geez
 

Trending Topics

Latest Posts

Forum Statistics

Threads
17,627
Posts
182,870
Members
59,290
Newest
tt11019
Back
Top Bottom