Oprah Winfrey Admits She’ll Likely Stay on GLP-1s for Life After Quitting for a Year and Regaining 20 Pounds

That seems like some hubris that she struggled with weight all her life and then thought she could just stop taking the GLP-1 when she hit goal weight. She is now on her own taper by spacing out doses by 10-14 days. I think spacing out administration and/or reducing dose by slow taper is a better approach in maintenance. Slow titrate up when it weight loss mode and then similar approach during taper. But I give her a lot of credit to admitting publically that she is taking a GLP-1 and then admitting her error and lesson learned.
 

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People need to look at GLP-1s the same way they look at high blood pressure medications or insulin. Once you need them, you need them for life.

The problem is most humans don't want to be dependant on anything for life. Since I work in medicine for a living, that was never a issue for me. I understood that from the beginning.

The second thing which should probably be first, is cost. Most people on GLPs are paying Pharmaceutical Cartel prices for their GLPs. Even with insurance, some find it expensive. Imagine paying out of pocket $500 a month for the rest of your life to keep your weight and health in check. For many who need these drugs, it's unpossible.

If people could obtain their GLPs the way we do, compliance would be a nonstarter.
 
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