Pep Chart

[SunMoonStars]

Anyone have chart of peps not to run together? I tried searching but couldn’t find. Thanks.

 

[Waclive]

I think a "harm reduction chart" would be a useful thing, especially when it comes to stacking different GLP-1s.

Right off hand, I cannot think of any absolute no-no's but I'm following this thread just in case anyone else does!

 

[Calm Logic]

Peptide interaction chart

Saw this somewhere thought of sharing with ya'll...

glp1forum.com

For mixing peptides, I believe it gives a false sense of security since we are mostly dealing with unknowns.

On the positive side, the biggest point of the chart was not to mix any GLPs together.

 

[Waclive]

I agree but there is a large population on reddit mixing tirz and reta together. Seems like a thing growing in popularity with people stacking them that are having diminished returns from one or the other.

 

[tubby]

Peptide interaction chart

Saw this somewhere thought of sharing with ya'll...

glp1forum.com

View attachment 11708

For mixing peptides, I believe it gives a false sense of security since we are mostly dealing with unknowns.

On the positive side, the biggest point of the chart was not to mix any GLPs together.

What's the thinking behind not mixing GLPs? I mean I'm not saying a person should do it, but (due to the long half-lives) every time a person switches from one GLP to another, they're de facto mixing, whether they realize it or not.

 

[Calm Logic]

What's the thinking behind not mixing GLPs? I mean I'm not saying a person should do it, but (due to the long half-lives) every time a person switches from one GLP to another, they're de facto mixing, whether they realize it or not.

I work in marketing, so I use Google Gemini, haha:

GLP-1s are large, complex protein molecules (peptides) that are highly sensitive to their environment. Each brand is formulated at a specific pH level and with specific preservatives (like phenol or metacresol) to keep the proteins folded correctly.

• The Risk: If you mix two different GLP-1 formulations in one vial, the different pH levels or chemical additives can cause the proteins to "unfold" or clump together.
• The Result: This can create a cloudy "precipitate" (tiny solids) in the liquid. If you inject a precipitated or degraded peptide, it may be ineffective or, worse, trigger an immune response or injection-site reaction.

 

[Waclive]

It sounds like from what I've been reading, the biggest issue is people over doing it because 1mg =/= 1mg from GLP-1 to GLP-1. Some people love the effects of reta and micro dose tirz for the food noise and slight appetite suppressant as the reta doesn't accomplish that for them. Some people are seeing plateaus and think more is good so they mix another one in.

I'm sure there are other reasons I'm not thinking of right now but that's the jist of it. I mean why mix cocaine and caffeine? Some people just like it I guess or are hella curious and like to push the limits. Or they're just adventurous scientists 😎

 

[Waclive]

I work in marketing, so I use Google Gemini, haha:

😂😂
Context is everything!
I wonder what it would say if you don't mean in a single vial but in the same bloodstream simultaneously 😆

 

[Calm Logic]

😂😂
Context is everything!
I wonder what it would say if you don't mean in a single vial but in the same bloodstream simultaneously 😆

It did that already too, to some degree (and was fine with both being in the system):

Pharmacokinetic Unpredictability

When you switch medications, the "mixing" in your blood is predictable because your liver and kidneys are processing each drug according to its known half-life.

• The Risk: If you mix them in a vial, they may interact before they ever enter your body. This can change how quickly the drug is absorbed from the fat under your skin into your bloodstream.
  
  
• The Result: You could end up with a "spike" of medication that causes severe nausea/vomiting, or a "dud" dose that doesn't control your blood sugar or appetite at all.

From playing with Gemini before, it talks about "pharmacological competition" at the GLP receptors.

For example:

Not all GLP-1s are created equal. They have different binding affinities—essentially, how "sticky" they are to the receptor.

• Semaglutide (Ozempic/Wegovy): Has an extremely high affinity for the GLP-1 receptor. It’s like a person who sits in the chair and refuses to move.
  
  
• Tirzepatide (Mounjaro/Zepbound): Interestingly, it has a weaker affinity for the GLP-1 receptor than native GLP-1 or Semaglutide. However, it makes up for this by also targeting the GIP receptor.
  
  
• The Competition: If you "mix" them in your blood, the Semaglutide might actually block the Tirzepatide from hitting the GLP-1 receptors efficiently. You're paying for a dual-action drug (Tirzepatide) but physically preventing it from performing half of its job.

 

[tubby]

I work in marketing, so I use Google Gemini, haha:

You may not have a technical background, but you're sharper about these things than you give yourself credit for.

And be sure to let Gemini know that we're not cracking open vials and mixing them together and that we're not sophisticated enough to use anything fancier than BAC water to reconstitute. LOL

 

[Waclive]

Grok had a bit to say about mixing them. Basically saying that it's growing in popularity to mix reta and tirz for the reasons I stated above. Reta being praised for superior in all ways except for the food noise. So mixing in a little tirz fixes that and people are having tremendous results with it.

However, mixing the others, tirz and sema, doubles the side effects and cancels out the benefits in most cases.

 

[tubby]

Grok had a bit to say about mixing them. Basically saying that it's growing in popularity to mix reta and tirz for the reasons I stated above. Reta being praised for superior in all ways except for the food noise. So mixing in a little tirz fixes that and people are having tremendous results with it.

However, mixing the others, tirz and sema, doubles the side effects and cancels out the benefits in most cases.

I see there being two possibilities when it comes to the reta vs tirz food noise controversy:

1: It's like you say (reta just isn't as good at that for some reason).
2: Reta is actually just as good at cancelling out food noise; however, the metabolic enhancements that come with reta are so good that your body is that much more energy-starved and the food noise is kind of a last ditch effort response to that. This would be similar to how (GLPs aside) someone will often feel hungrier after an intense workout than they would feel if they hadn't worked out.

 

[MsGizmo]

Peptide interaction chart

Saw this somewhere thought of sharing with ya'll...

glp1forum.com

View attachment 11708

For mixing peptides, I believe it gives a false sense of security since we are mostly dealing with unknowns.

On the positive side, the biggest point of the chart was not to mix any GLPs together.

What that chart is trying to say is to not take ANYTHING along with a GLP. While at the same time the chart itself combines all the GLPs into one. In my opinion this chart is almost entirely useless because there it no source given for the data.

I also don't think this is intended to be an interaction chart but is a "can this be mixed into one injection chart."

 

[Chili777]

Peptide interaction chart

Saw this somewhere thought of sharing with ya'll...

glp1forum.com

View attachment 11708

For mixing peptides, I believe it gives a false sense of security since we are mostly dealing with unknowns.

On the positive side, the biggest point of the chart was not to mix any GLPs together.

When this came out, I thought I saw something saying this was guidance for mixing in the same vial or syringe? I'm not sure this is saying don't stack them or use them together, is it?