Peptides for Arthritis?

Did you try the 🔍 tool? There’s 3 pages of posts about arthritis.

It would help to know the specific type of arthritis - osteo, erosive osteo, rheumatoid, etc as they all have different inflammatory markers and may be less responsive to a peptide.
 
PopTart said:
Did you try the 🔍 tool? There’s 3 pages of posts about arthritis.

It would help to know the specific type of arthritis - osteo, erosive osteo, rheumatoid, etc as they all have different inflammatory markers and may be less responsive to a peptide.
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I have. Seems like some people have had good experience with tirz but all sorts of results are all over different threads... Would just like everybody's experience to be in one place and it seemed like this was the right subforum...

PsA is the one I'm most concerned about, but I'd love to hear everybody's experiences regardless if they're willing to share.
 
I have rheumatoid. Tirz helped in the beginning but hasn't helped lately. Idk if it's cause it's crazy cold where I am or what. I also tried tb & bpc, didn't see much difference in day to day relief but it did help overall soreness and stiffness after a workout.
 
I'm also curious... I have osteoarthritis in my knees. I've taken Synvisc which is a liquid membrane but it only lasted maybe a month... it was supposed to last 6 months.
 
pepshi said:
I'm also curious... I have osteoarthritis in my knees. I've taken Synvisc which is a liquid membrane but it only lasted maybe a month... it was supposed to last 6 months.
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Same for me, tried Synvisc, lasted about 4 months, switched to Euflexxa, that lasted about a year. Next step is Durolane but insurance can't seem to make up their mind on coverage grrr. My brother on the other hand has had very good luck with Synvisc, going on 4+ years with only 3 injections, he's running around the basketball court like the energizer bunny.
 
Anon7482 said:
PsA is the one I'm most concerned about, but I'd love to hear everybody's experiences regardless if they're willing to share.
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I have a family member with PsA. Humira worked until insurance stopped covering it this year. They are trying a generic replacement when the Humira stockpile runs out. As far as peptides, KLOW didn’t do much. We are considering options if the generic Humira replacement doesn’t work. Since they are of normal weight without other factors, GLP-1s aren’t on the table unless maybe a small dose of Tirz helps. I don’t want to introduce GI side effects.
 
I am also very interested in this. GLPs helped to a point, but that was maybe just less weight on the old knees
 
CheesyPotato said:
Same for me, tried Synvisc, lasted about 4 months, switched to Euflexxa, that lasted about a year. Next step is Durolane but insurance can't seem to make up their mind on coverage grrr. My brother on the other hand has had very good luck with Synvisc, going on 4+ years with only 3 injections, he's running around the basketball court like the energizer bunny.
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Glad it worked for your brother... at this point I would go for surgery if they could repair it somehow but that's not an option yet 🙁
 
Anon7482 said:
Anybody here have to deal with arthritis? What helped? Insurance isn't helpful and neither is popping twelve ibuprofens a day...
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PopTart said:
Did you try the 🔍 tool? There’s 3 pages of posts about arthritis.

It would help to know the specific type of arthritis - osteo, erosive osteo, rheumatoid, etc as they all have different inflammatory markers and may be less responsive to a peptide.
Click to expand...
Like PopTarT said......Here is my experience.

 
CheesyPotato said:
Gila monster venom, never in a million years would I have guessed that, very interesting. Honestly, never dove into the history, thanks for sharing this.
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Yeah .. it just highlights the fact that all species are valuable and we shouldn't let them die out. You never know where a useful medicine is going to come from.
 
Anon7482 said:
Anybody here have to deal with arthritis? What helped? Insurance isn't helpful and neither is popping twelve ibuprofens a day...
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I put a pack of plain gelatin in my EAAs every day. Learned that from my grandparents.

Don't need it in the summer time though.
 
This is pretty basic, but a critical tool I use for managing joint inflammation and autoimmune is my diet. There's plenty of other stuff, but simply replacing/avoiding foods that are inflammatory for me was life-changing.
I would rather avoid and limit certain foods in order to be able to walk, work, sleep, socialize, enjoy my hobbies, etc...
 
I felt that taking a boron supplement was a game changer. I wasn't able to sleep on my side due to hip pain which also made me stop running my daily 2-4 miles. After taking boron, I feel the pain is reduced significantly. It is an essential mineral which should be in foods but as soils nowadays are so depleted of nutrients, we barely get any from crops as we should. It has also helped me hormonally with perimenopause. Another interesting fact is that it can decalcify the pineal gland caused by fluoride in our water. Interesting enough, a lot of peps work by stimulating the pineal gland, so it might even help boost their effectiveness. There is a NIH PubMed article called "Nothing boring about boron". Good read if you want to understand more in detail.
 
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Crumplestiltskin said:
This is pretty basic, but a critical tool I use for managing joint inflammation and autoimmune is my diet. There's plenty of other stuff, but simply replacing/avoiding foods that are inflammatory for me was life-changing.
I would rather avoid and limit certain foods in order to be able to walk, work, sleep, socialize, enjoy my hobbies, etc...
Click to expand...
what foods?
 
Crumplestiltskin said:
This is pretty basic, but a critical tool I use for managing joint inflammation and autoimmune is my diet. There's plenty of other stuff, but simply replacing/avoiding foods that are inflammatory for me was life-changing.
I would rather avoid and limit certain foods in order to be able to walk, work, sleep, socialize, enjoy my hobbies, etc...
Click to expand...
💯. The AIP diet helps a lot. For me, triggers were foods with white vinegar, synthetic citric and malic acids, synthetic sugars, and sometimes uric acid from purine in some meats.
 
laansasa said:
I felt that taking a boron supplement was a game changer. I wasn't able to sleep on my side due to hip pain which also made me stop running my daily 2-4 miles. After taking boron, I feel the pain is reduced significantly. It is an essential mineral which should be in foods but as soils nowadays are so depleted of nutrients, we barely get any from crops as we should. It has also helped me hormonally with perimenopause. Another interesting fact is that it can decalcify the pineal gland caused by fluoride in our water. Interesting enough, a lot of peps work by stimulating the pineal gland, so it might even help boost their effectiveness. There is a NIH PubMed article called "Nothing boring about boron". Good read if you want to understand more in detail.
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are there any specifics about the boron you take? Ie is it like Magnesium with many forms?
 
desinr-gal said:
are there any specifics about the boron you take? Ie is it like Magnesium with many forms?
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I take 1/8 teaspoon sodium borate (borax) but the FDA and big pharma have demonized it even though it is what my grandparents took. You can get boron citrate (nutircost) or bororganic glycine (NOW supplements) on amazonnif you are scared of Borax. There is a huge group on FB filled with testimonials like mine.
 
laansasa said:
💯. The AIP diet helps a lot. For me, triggers were foods with white vinegar, synthetic citric and malic acids, synthetic sugars, and sometimes uric acid from purine in some meats.
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AIP is a huge help! Dairy, gluten, soy, and nightshades were all major contributors to inflammation.
That's awesome you were able to identify even the uric acid issue.
By the way, do you find boron to be estrogenic at all for you?
 
Crumplestiltskin said:
AIP is a huge help! Dairy, gluten, soy, and nightshades were all major contributors to inflammation.
That's awesome you were able to identify even the uric acid issue.
By the way, do you find boron to be estrogenic at all for you?
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I think so. It has helped my menstual cycle become more regular since perimenopause. I was always clockwork accurate my whole life until 2 years ago it began to shift by 1 week (sometimes early sometimes late). I'm 46 and back to normal. I have bloodwork coming up soon and should be interesting to see levels after noticing they were slowly decreasing. I am also taking shatavari to regulate hormones. I took oral birth control for 1 year in 2025 as suggested by my OB/GYN but it made things worse (instead of better) . It tanked everything including my progesterone, libido, and metabolism.
 
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laansasa said:
I think so. It has helped my menstual cycle become more regular since perimenopause. I was always clockwork accurate my whole life until 2 years ago it began to shift by 1 week (sometines early sometimes late). I'm 46 and back to normal. I have bloodwork coming up soon and should be interesting to see levels after noticing they were slowly decreasing. I am.also taking shatavari to regulate hormones. I took oral birth control for 1 year in 2025 as suggested by my OB/GYN but it made things worse (instead of better) . It tanked everything including my progesterone, libido, and metabolism.
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That is really helpful to know about the support for peri. I had tried it years ago and had estrogenic symptoms, but I think it would helpful to try again.
By the way, I have to add for anyone else: it was not at ALL toxic. Boron is awesome.
 
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