Peptides for brain health / dementia

[Bsqueezin]

There are a lot more smart people than me in these forums and I am curious your thoughts on the best peptides for brain health / dementia prevention?

My family is extremely prone to dementia to the point where if you're a male, you are at a 100% chance of getting it later in life. I would love any idea on any peptides that you fine people may know that could help with brain function and/or help prevent dementia. I know there won't be anything that 100% blocks it, but anything that can help slow it down when I get to my older age would be awesome.

 

[eidos]

Cyclic Glycine-Proline Improves Memory and Reduces Amyloid Plaque Load in APP/PS1 Transgenic Mouse Model of Alzheimer's Disease

https://pmc.ncbi.nlm.nih.gov/articles/PMC9995210/

One tablespoon of dried blackcurrants per day provides the amount used in the study.

 

[headward]

This might be a good place to start:

My Limitless Stack - Nootropics

I have to admit, I’m only mildly interested in GLP-1s, and I know this forum is primarily dedicated to them. To be fair, I was on Reta for six months and also briefly tried Cagri, but my main area of interest is performance enhancement, particularly nootropics. These are the compounds I’m...

glp1forum.com

 

[rkbleddyn]

Cerebrolysin is the one I keep hearing about. I did find one source for that. I have not tried it myself.

That being said, I do use a peptide to try to increase BDNF and dampen down the stress I have to endure from my high stress job. That peptide is Semax and it does work, for me. It is also supposed to be neuroprotective, as is Selank, which I also use.

Those are the main 3 that I know about.

 

[bada bing]

Not peptides, but preventatives I use:
Omega 3 (fish oil) - get your Omega 3 index tested and maintain it at least 8%, 12% is better
Lithium - low dose OTC supplement
MCT oil - good coffee creamer. The ketones it creates are an alternative brain fuel
Get your APOE4 gene status tested.
And of course, keep your weight down and your HbA1c low. Reta and/or Tirz

I have a family history of dementia, nearly 100%, but all my grandparents, parents, aunts and uncles made it to 85 or later before it showed up. In my family, at least so far, we all live long lives but spend the last 2-5 years out of our friggin minds.

 

[tendency]

There are a lot more smart people than me in these forums and I am curious your thoughts on the best peptides for brain health / dementia prevention?

My family is extremely prone to dementia to the point where if you're a male, you are at a 100% chance of getting it later in life. I would love any idea on any peptides that you fine people may know that could help with brain function and/or help prevent dementia. I know there won't be anything that 100% blocks it, but anything that can help slow it down when I get to my older age would be awesome.

Start with the basics. Have you done baseline bloods?

Without seeing these a good starting point, IMO, would be to microdose Tirz to heal and keep healthy your metabolism.

 

[Goonwise]

https://pmc.ncbi.nlm.nih.gov/articles/PMC9995210/

One tablespoon of dried blackcurrants per day provides the amount used in the study.

Amyloid plaques are not confirmed to be the reason behind Alzheimers or dementia. It seems to be correlated though.

 

[eidos]

Amyloid plaques are not confirmed to be the reason behind Alzheimers or dementia. It seems to be correlated though.

None of this has been elucidated yet.

cGP affects IGF-1 levels (https://www.nature.com/articles/srep04388)
that it is known to activate the insulin receptor.
There are links between Alzheimer's disease and type 2 diabetes (https://pubmed.ncbi.nlm.nih.gov/35269827/)
I'm hypothesis that there's a link on that side.

Another factor that adds to this is how aGLP-1s have a nootropic effect and are being considered as a treatment for Alzheimer's.
I've already mentioned in another thread the cognitive acuity I regained after the first few months of Victoza, and which has remained with Tirz and Reta. (Just old, not completely senile, yet...)

 

[Meritocrat]

1. Cerebrolysin
2. P-21 Adamantane.
3. Adalank- Adamax + Selank
4. Noopept, Citicholine, Modafinil, Irisin.
5. Amylin, PHPD5, FGL, NAP
6. pentapeptide Nle1-YIHP and tetrapeptide Nle1-YIH.
7. SPADIN, DIHEXA, Cholecystokinin Octapeptide (CCK-8), ARA-290, Vesugen, vilon
8. Cortagen, Racetams, Bemethyl, Methylene Blue, 4'-DMA-7,8-DHF (Eutropoflavin), 9-Methyl-β-carboline (9-me-bc), PRL-8-53 (methyl 3-(2-(benzyl(methyl)amino)ethyl)benzoate),

 

[coach chickpea]

There are a lot more smart people than me in these forums and I am curious your thoughts on the best peptides for brain health / dementia prevention?

My family is extremely prone to dementia to the point where if you're a male, you are at a 100% chance of getting it later in life. I would love any idea on any peptides that you fine people may know that could help with brain function and/or help prevent dementia. I know there won't be anything that 100% blocks it, but anything that can help slow it down when I get to my older age would be awesome.

Have u looked into selank/semax?

 

[lessthanhalf]

I do not know if there are hereditary syndromes causing dementia that are preventable at this point with conventional medicine, but if risks are that high it might be worth a neurologist opinion. Unless you prefer not to know of course.

GLP peptides have a lot of preclinical data saying they are strongly neuroprotective, but evidence in humans is much weaker and less consistent. It is possible that they need to be started before any substantial damage is done to prevent dementia, but this is far from proven, but much better evidence than other peptides.

One of the enormous problems with Alzheimer's is that of basically all the different treatments tried that work in mice or rat models of the disease, have failed when tested in humans, at least a dozen totally different approaches.

 

[Builderman]

I have heard those diseases being called “type 3 diabetes” and not sure how true that is. So I really wonder what kind of effect the glp1s would have on preventing.

 

[lessthanhalf]

There is definitely something going wrong with glucose metabolism in the brain in Alzheimer's. Unfortunately there are things going wrong with tau, amyloid, glial and astrocyte cells, mitchondrial function, protein production and recycling systems, the blood brain barrier, the gut microbiome and its metabolites, inflammation in the brain, and likely several more I cannot list off the top of my head. The problem is which starts the process or even simply where is a time and place to intervene to stop it developing, getting worse or even to fix it, and they are nowhere near that answer yet.

The brain is full of glp-1 receptors, even in lots of places not obviously related to food or appetite, and GLP-1 drugs only access the brain in a few limited places where the blood brain barrier is weakest, but they can still have indirect effects via altering a pile of other signalling hormones and vagal tone that do not get blocked by the blood brain barrier.

Of the drugs currently around GLP agonists, might prevent or slow Alzheimer's if taken early enough, but the evidence is weak. If there are other good reasons to take it like obesity, then it is just another possible benefit, and they are proven to reduce risks of diabetes, heart attacks, strokes, several different cancers, and a pile of other diseases. It is going to take many years to answer the question for dementia, but it is being very actively researched and viewed as promising.

 

[eidos]

I have heard those diseases being called “type 3 diabetes” and not sure how true that is. So I really wonder what kind of effect the glp1s would have on preventing.

I included the references in a reply above. The first article to discuss diabetes in this context dates back to the 2000s. In people with Alzheimer's who were taking Ozempic, the disease was observed to go backwards.

 

[Chili777]

There are many informative and detailed threads here on Cerebrolysin, Semax, Selank, Epitalon, PE-22-28, Adamax and other peptides that focus on cognitive enhancement.

 

[Calm Logic]

Lithium - low dose OTC supplement

Ask any nephrologist what they think of that. I did. Not good for the kidneys, OTC or not.

In theory, HGH is great for the brain too. But you can't separate the brain from the body.

 

[BigDaddyJ]

Cerebrolysin is the one I keep hearing about. I did find one source for that. I have not tried it myself.

That being said, I do use a peptide to try to increase BDNF and dampen down the stress I have to endure from my high stress job. That peptide is Semax and it does work, for me. It is also supposed to be neuroprotective, as is Selank, which I also use.

Those are the main 3 that I know about.

Not to hijack the thread, but how did the Semax work on memory recall? I’m thinking about it for a work related test coming up. Yeah I can cram but my test anxiety just basically empties my brain. I was thinking about doing it for like 2 months prior to the test. Have you noticed anything along those lines?

 

[lessthanhalf]

Ask any nephrologist what they think of that. I did. Not good for the kidneys, OTC or not.

In theory, HGH is great for the brain too. But you can't separate the brain from the body.

Lithium may have neuroprotective effects, but by no means definitive or proven. The doses available as supplements are 20 to 50 times lower than standard therapeutic dose lithium as used for bipolar disorder etc, to the best of my knowledge doses at 5 or 10mg a day as are available in supplements and not prescription are not toxic to the kidneys, but therapeutic doses of lithium certainly are.

 

[bada bing]

Ask any nephrologist what they think of that. I did. Not good for the kidneys, OTC or not.

In theory, HGH is great for the brain too. But you can't separate the brain from the body.

Poison is in the dose.
The amount of Lithium used as a prophylactic against Alzheimer's is miniscule compared to the levels dosed for bipolar disease, which is where the concern for kidney damage comes from. In bipolar disease, a common dosing is 600mg 3 times daily during mania and 300mg 4 times a day during maintenance. Many people suffering from bipolar are on Lithium therapy indefinity. A common OTC Lithium Orate supplement contains 5mg daily. The supplement dosage is well within the exposure levels of large areas with higher levels of Lithium in the groundwater. That is what initially clued researchers into the connection of low Lithium with Alzheimer's, Alzheimer's is more prevalent in areas with low Lithium levels in the drinking water.

The preliminary data on Lithium Orate usage for slowing the progression of Alzheimer's isn't quack science. Harvard is one of the leading investigators and several papers have been published in the frontline journals. It is much, much better vetted than peptides recommended for cognitive enhancement.

View: https://www.youtube.com/watch?v=pkcJEvMcnEg

 

[Thistley]

I think there is some level of consensus around metabolic disease/ damage being a factor in development of some forms of dementia. Semax for increased cognitive function I have certainly heard of but honestly people are getting pretty excited about creatine - which is not a peptide but has a strong body of research around its safety. Safe to take as a food supplement.

I think the suggested dose for brain health is around 20mg per day I believe but lots of studies out there worth reading. If there is a strong history in the family I would be on the creatine right away. It’s safe and most people probably would benefit.