Phase 1 study for Eloralintide and Terzepitide

[yeddie]

David W at his blog has a new post about Eli Lilly releasing preliminary results for Eloralintide combined with Terzepitide. As expected it looks promising.

Eloralintide + Tirzepatide = Bariatric Surgery results!​

(Yes, he's a fan.)

This is what Novo thought CagriSema could do.
These are short trials and in no way was there a weight plateau in any arm. This isn’t even the max potential weight loss with this combination. That being said I have a genuine concern that this weight loss is too rapid. Perhaps this is why Lilly has Enlighten-6 which combines eloralintide plus either semaglutide or tirzepatide AFTER you’ve stalled out on weight loss on either of those two agents first.

 

[Scorpio73]

Nice!. are these actually new 2026 human data?

I've only seen the published 2025 eloralintide monotherapy results. Where did these combination numbers come from?

Are these from a conference abstract, a Lilly poster, an investor deck, or something else? I'd love to read the original source if anyone has a link.

 

[Countyroad233]

love this, thank you

 

[leokitcat]

Holy heck that’s some incredible weight loss! In the reta p3 trial is took 104 weeks to get to 30% weight loss compared to 32 weeks or so with tirz+elora

 

[HouseCat]

Thanks for posting this - I am PSYCHED!!! And can’t wait til my Elora comes in later this summer.

 

[Enyola]

Nice!. are these actually new 2026 human data?

I've only seen the published 2025 eloralintide monotherapy results. Where did these combination numbers come from?

Are these from a conference abstract, a Lilly poster, an investor deck, or something else? I'd love to read the original source if anyone has a link.

It's in the article:
"that’s what I found today, when I was looking at the abstracts for the upcoming EASD 2026 (European Association for the Study of Diabetes) conference." (no direct link though, probably not public yet).

 

[m100568]

Low dose Elora and Reta is what I am going to be experimenting with for maintenance. I want high appetite suppression with stable weight. I'm down 112lbs, which is 46% of my body weight and puts me at a BMI of 21. Currently on 4mg Elora (with no side effects) and planning on titrating down to 4-5mg Reta. This is a work in progress, so I haven't drawn any conclusions. I like the idea of maintaining on lower doses, rather than the recent Tirz study that says you have to stay at your highest effective dose to maintain. The small Elora study showed 17% average weight loss on 3mg Elora and 5mg Tirz, in 16 weeks, with no plateau.

For those who haven't seen it, a summary of the Tirz maintenance study is below:

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SURMOUNT-MAINTAIN: Maximum Dose vs. Dose Reduction​

This specific trial evaluated what happens when you lower your dose for maintenance versus staying on your maximum tolerated dose (MTD) of 10 mg or 15 mg (Horn, 2026).

• The Setup: Participants lost weight over an initial 60-week period while titrating up to their maximum tolerated dose (10 mg or 15 mg). They were then randomized into three groups for a 52-week maintenance period: keeping their maximum dose, dropping down to a low maintenance dose (5 mg), or switching completely to a placebo.
• The Findings:
  • Maximum Tolerated Dose (10 mg or 15 mg): Participants maintained their full weight loss, finishing the trial with an average total weight reduction of -21.9%.
  • Reduced Dose (5 mg): Participants regained a portion of their weight, finishing with an average total weight reduction of -16.6%. Over 25% of the people in this group experienced enough weight regain to require rescue therapy.
  • Placebo: Participants experienced substantial weight regain, finishing with a total net loss of only -9.9% from their original baseline.