Question About KLOW 80mg – Is the 5 Days On, 2 Days Off Schedule Evidence-Based or Just Anecdotal?

[TK1!!]

Thanks for this tip! I received my GHK-BASIC yesterday and added it to my KLOW cartridge. It didn't hurt or irritate going in and I don't have a new pink splotch on my skin, either. 😍

 

[SmokinDog Cujo]

Just letting people know that currently the best known method for dealing with spicy ghk-cu is to add a small amount of ghk-basic.

How much GHK basic should be added to an 80mg vial? Is there a known protocol you can point me toward?

Thanks!

 

[zpped]

How much GHK basic should be added to an 80mg vial? Is there a known protocol you can point me toward?

Thanks!

trial and error because it depends on the ghk-cu you are mixing it with. Personally I use 2:1 cu:basic to save time. Fortunately the ghk allows for pretty high dosage variance so I don't worry about it.

but you could try 5:1 since ghk basic is hard to source and you could make a kit of basic last a long time that way. if its still stingy, just try 4 or 3:1

 

[Labcat]

Sorry for the wall of science answer , but you did ask.

There are no clinical trials of KLOW or GLOW in humans. Or in animals that I could find.

There have been 3 small clinical trials in humans of BPC 157 , for arthitis, cystitis and basic phase 1 toxicity test. Nearly all the research comes from a small localised set of researchers. The paper I read by them was dodgy AF. DOI: 10.3390/ph16050676 . Basically claiming it was a miracle cure, not differentiating between animal and human tests when talking about evidence and massively overstating its effectiveness compared to the evidence. No real research anywhere else. If it was as good as some of the rodent studies suggest this would not be the case.

There have been clinical trials of GHK-Cu in humans but only applied externally to the skin, not injected or oral treatment. Not being developed as a systemic treatment

There have been clinical trials of thymosin beta 4 in humans , it is currently being tested as an PCI injection (percutaneous coronary intervention), after heart attacks, and a phase 1b study iv for basic safety for use in humans

As far as I can tell KPV has never been tested in humans. It is still being researched mainly as nanoparticles with kpv attatched as a therapy for ulcerative colitis but not near human testing

There is zero doubt that these peptides do things, often quite beneficial things in the body. The problem is partly that most are not patentable so no company will pour money into researching them, only publicly funded research, and they mostly have too many effects. Drug companies generally want compounds that do a single specific thing to one receptor ( that is well studied and understood ) so it is possible to work out the effects, and there are no off target effects . So they don't spend a billion dollars on research only to find some unexpected adverse effect. Most of the peptides in KLOW have very broad effects, on many different body systems, and in general are not well understood. Trying to work out all these effects would require an enormous amount of research, before human trials could be considered, and then they would have to be huge in scale to make sure less common effects were found given the incomplete understanding of how they work.

Unfortunately just because lab and animal studies look good does not mean they will work in humans. There are dozens of treatments that prevent, treat or reverse Alzheimer's disease in rat and mouse models, but they have all failed ( to make more than a minor difference ) when tested in humans.

Going on anecdotal reports online, many people have said it has helped make healing faster, which is interesting and is a sort of evidence, unfortunately it does not prove anything. Before the scientific method people believed a lot of very weird things were effective treatments, blood letting by leeches was very popular for centuries.

The most obvious concern is that many of them significantly alter growth signals and angiogenesis, which produces reasonable concerns about the possibility of initiating or enhancing the growth of tumours, and the fact that their effects are not well understood. Most of these peptides are not likely to have further development as drugs, and I do not think any researchers would ever test klow on humans in a clinical trial due to the complexity and unpredictability of its possible effects.

This is spot on and so well written. Every bit of this is true, unlike the marketing we read about KLOW everywhere. (I’d really like it to work though). The bit about how we have cured mice of Alzheimers so many ways but still have next to nothing for people is depressingly true and indicative of how complex human physiology is.

The only thing I can think of to add to this excellent review is that TB500 (Tβ4) expression is known to be associated with several common human cancers and metastases. So extra caution is warranted.

 

[trojanpeptide]

Yea, TB500, BPC157 are upregulating VEGF. I think GHK may also be; at least it modulates it.
Anything that could exasperate dilation of the aorta or be associated with aneurysm growth :/

Discussing with AI helps, but that's like dining with the devil; enchanting but yur playing with fire. Idk if I will even use the kit I ordered.

I don't understand why our society doesn't respect ourselves enough to conduct these trials, even from a government standpoint... too much greed in this world.

 

[Labcat]

I’ve been digging around the web and I can’t find any solid evidence for why the “5 days on, 2 days off” schedule is considered ideal for KLOW. Some people follow that, some people dose daily, and I found one mention here:




Does anyone here have clinical or peer-reviewed evidence for that cycling approach with KLOW, or is it purely anecdotal at this point?

Yea, TB500, BPC157 are upregulating VEGF. I think GHK may also be; at least it modulates it.
Anything that could exasperate dilation of the aorta or be associated with aneurysm growth :/

Discussing with AI helps, but that's like dining with the devil; enchanting but yur playing with fire. Idk if I will even use the kit I ordered.

I don't understand why our society doesn't respect ourselves enough to conduct these trials, even from a government standpoint... too much greed in this world.

Oh, yes , good point indeed; they all do. Some of us perhaps could do okay with a little more, certainly we do not all probably have the same baseline, but it’s completely unclear where and how much our pins would be affecting target tissues . If we only studied meds in depth when it’s not all about profit.

 

[tendency]

Just letting people know that currently the best known method for dealing with spicy ghk-cu is to add a small amount of ghk-basic.

Not sure about that, I've taken to diluting 50mg GHK-cu w/ 10ml of BAC and that has eliminated all ISR/PIP issues for me. Using less that that I'll start getting injection issues.

 

[zpped]

Not sure about that, I've taken to diluting 50mg GHK-cu w/ 10ml of BAC and that has eliminated all ISR/PIP issues for me. Using less that that I'll start getting injection issues.

What aren't you sure about?

I'm saying if you added a small amount of ghk-basic you wouldn't have to dilute to 5mg/ml. (which wouldn't work for me because I don't want to inject 2ml when I'm taking 10mg)

Dilution is somewhat effective. Binding the free copper with ghk-basic is highly effective.

 

[Labcat]

What aren't you sure about?

I'm saying if you added a small amount of ghk-basic you wouldn't have to dilute to 5mg/ml. (which wouldn't work for me because I don't want to inject 2ml when I'm taking 10mg)

Dilution is somewhat effective. Binding the free copper with ghk-basic is highly effective.

I’m curious as to what the GHK basic does… I had read the Cu was already stably chelated to the GHK (at pH in physiologic range, but releases Cu at pH<4 or >9).

Has anyone tested what pH the painful recon is at? Or is it thought that somehow some Cu ions get loose anyway and the additional GHK mops them up so loose Cu ions are less concentrated? (Whereas the additional BAC dilutes them so it’s less concentrated?)