Reconstituted Tesamorelin storage…

bogardbilla said:
Going back to this 🙂 If this interpretation of that test is correct, it would imply that Egrifta - a commercial product, packs Tesamorelin with excipients that effectively make it have twice as short of a shelf life when reconstituted as opposed to grey market Tesamorelin.

I wonder what these Egrifta-specific excipients bring to the equation if the pharma company thought their usage was warranted despite the fact they make the end product more inconvenient for the patients.
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Excipients make the API more bioavailable, so you need less of it. That is the convenience they think they're bringing. They are not, and never have been concerned with longer shelf life.
 
I've had 3 gel up of this kit from GYC. I've tried super gentle recon with 2.5 ml BAC. I've tried different BAC. Kept in fridge and kept room temp. The one I reconned last night I took as much care as possible and stored at RT now it's already starting to gel tonight. I don't know what else to try... help!
 
Interesting thread.

I have used tesamorelin numerous times and never experienced any issues with vials geling and I have always stored them in the refrigerator. In general I had never heard of this specific issue attributed to this compound aside from on this forum.
 
Ultra_Unlimited said:
Interesting thread.

I have used tesamorelin numerous times and never experienced any issues with vials geling and I have always stored them in the refrigerator. In general I had never heard of this specific issue attributed to this compound aside from on this forum.
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Gelling issues were a common issue when I was looking around the interwebs for information about GH secretagogues. I'm not sure why you think this is forum specific. It is not.

I've seen a whole lot of "fixes" none of which have any actual science behind them just anecdotal evidence.

High ph, low ph, refrigerate, don't refrigerate, be super extra gentle when recon, don't put in door of fridge, etc.
 
yrrdead said:
Gelling issues were a common issue when I was looking around the interwebs for information about GH secretagogues. I'm not sure why you think this is forum specific. It is not.

I've seen a whole lot of "fixes" none of which have any actual science behind them just anecdotal evidence.

High ph, low ph, refrigerate, don't refrigerate, be super extra gentle when recon, don't put in door of fridge, etc.
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Interesting.... initially i used bac that was prolly 6 weeks old and the tesa gelled. Used fresh bac and gelled. Now i opened a 10ml vial of a different brand bac and the tesa has been liquid for an hour or so....
 
Airborne Daddy said:
Interesting.... initially i used bac that was prolly 6 weeks old and the tesa gelled. Used fresh bac and gelled. Now i opened a 10ml vial of a different brand bac and the tesa has been liquid for an hour or so....
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Now get some pH strips and test all the BAC and report back.
 
yrrdead said:
Now get some pH strips and test all the BAC and report back.
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Damn didnt think of it.... ordered more of the same bac and liposomal vit c 5 minutes ago.... im gonna add them thanks. What should bac be at anyway? added 200 ph strips thanks again!
 
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Airborne Daddy said:
Christ didnt think of it.... ordered more of the same bac and liposomal vit c 5 minutes ago.... im gonna add them thanks. What should bac be at anyway? added 200 ph strips thanks again!
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I was going to answer 5.7 but I figured I should look it up. Turns out its hard to actually measure BAC water pH. Or harder than it should be. That being said it should be acidic but not super acidic. The range given is 4.5-7 by Pfizer. Which is pretty large for pH (log scale). If I was looking at nonHospira and it came back around 6 I would be pretty happy.
 
Anyone try filtering? Wondering if that may help the gelling.
 
yrrdead said:
I was going to answer 5.7 but I figured I should look it up. Turns out its hard to actually measure BAC water pH. Or harder than it should be. That being said it should be acidic but not super acidic. The range given is 4.5-7 by Pfizer. Which is pretty large for pH (log scale). If I was looking at nonHospira and it came back around 6 I would be pretty happy.
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So im guessing my bac was trash. This is the newer stuff that worked, ordered a few more 3 packs. I think the hospira is 90% counterfeit unless you buy where a medical license is required. Bac water doesnt have to be difficult for 1.5 cents of benzyl alcohol but i seen the study where basically 7 of 10 bigger sellers all failed.

Ridiculous cuz you have 2 man operations where dudes can get 10 different aas compounds dialed in but actual distributors cant get sterile water with .9% ba....
 

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I got Tesa from an expensive US supplier before. Was refrigerated and no gelling. Just got a kit sent and will be reconstituting this weekend. Was going to use some Bac water I have on hand but now I’m thinking I’ll wait for my H bac water order to get here.

The only thing I can think is that there may be a difference in preservatives between manufacturers and it would come down to how Tesa and the preservative binds instead of mixing when water is added?
 
I haven't experienced gelling in my tesa. I recon 10mg with 1ml bac and store it in the fridge then pin 2mg before bed every day. I also usually recon a vial to be a standby at about 2/3 of the way through the current vial. So I'd say on average my reconstituted vials are refrigerated for approx. 7-8 days. And as for the degradation, my refrigerated tesa has bumped my IGF-1 levels from 158 up to 291. So it's obviously working despite any potential storage issues.IGF-1 test results 01-22-2026.webp
 
To recap, below are two horrible ideas, especially in combination (unless you are bacteria):

1) Storing reconned tesa at room temperature

2) Not using Hospira BAC water

People get a false sense of security with non-Hospira BAC water since nothing else gelled on them. But tesa is the canary in the coal mine with the pH requirements of BAC water.

And using Chinese/Amazon BAC water could increase the risks of bacterial growth, which would be much higher if not refrigerating tesa after recon.
 
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Ngl, this is very interesting, I hope there's gonne be more research on it soon. I have been reading that adding acetic acid solves the issue, but I wonder if that has any other detrimental effects.
 
Calm Logic said:
To recap, below are two horrible ideas, especially in combination (unless you are bacteria):

1) Storing reconned tesa at room temperature

2) Not using Hospira BAC water

People get a false sense of security with non-Hospira BAC water since nothing else gelled on them. But tesa is the canary in the coal mine with the pH requirements of BAC water.

And using Chinese/Amazon BAC water could increase the risks of bacterial growth, which would be much higher if not refrigerating tesa after recon.
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Seems the structure of the raw Tesamorelin molecule has a hydophillic aspect that makes it prone to clumping in colder solution ... this overview by Jim [HPT Homopetides Telegram] https://t.me/c/2966968184/8787
outlines the issue "
Tesamorelin has been through three FDA approved formulations over the last 15 years, and the storage requirements tell you everything you need to know.

The original formulation was approved in 2010. Pharmaceutical grade, no stabilizers, and the label said reconstitute and inject immediately because it couldn't sit in solution for a single day.

Then in 2018, EGRIFTA SV came out at a higher concentration and the instructions were the same. Do not store it. Do not refrigerate.

So that's two formulations across eight years, and neither one could be stored after reconstitution.

Then in 2025, they finally solved it by engineering 145 milligrams of a stabilizer into the formulation that wraps around the hydrophobic parts of the molecule and keeps them from clumping together.

And with that, the FDA approved a seven day shelf life for the first time.
At room temperature, still not refrigerated.

The problem is the molecule, not the formulation. Tesamorelin has a synthetic modification on the front end that repels water and the amino acid sequence itself is loaded with hydrophobic residues.

When the temperature drops, those regions on adjacent molecules start binding to each other and that causes gelling.

Those properties are built into the amino acid sequence and exist in every vial of tesamorelin on the planet, regardless of who made it.

The FDA version has a stabilizer engineered to manage that problem. Research grade does not. " ...

HTH
 
Wally H said:
Seems the structure of the raw Tesamorelin molecule has a hydophillic aspect that makes it prone to clumping in colder solution ... this overview by Jim [HPT Homopetides Telegram] https://t.me/c/2966968184/8787
outlines the issue "
Tesamorelin has been through three FDA approved formulations over the last 15 years, and the storage requirements tell you everything you need to know.

The original formulation was approved in 2010. Pharmaceutical grade, no stabilizers, and the label said reconstitute and inject immediately because it couldn't sit in solution for a single day.

Then in 2018, EGRIFTA SV came out at a higher concentration and the instructions were the same. Do not store it. Do not refrigerate.

So that's two formulations across eight years, and neither one could be stored after reconstitution.

Then in 2025, they finally solved it by engineering 145 milligrams of a stabilizer into the formulation that wraps around the hydrophobic parts of the molecule and keeps them from clumping together.

And with that, the FDA approved a seven day shelf life for the first time.
At room temperature, still not refrigerated.

The problem is the molecule, not the formulation. Tesamorelin has a synthetic modification on the front end that repels water and the amino acid sequence itself is loaded with hydrophobic residues.

When the temperature drops, those regions on adjacent molecules start binding to each other and that causes gelling.

Those properties are built into the amino acid sequence and exist in every vial of tesamorelin on the planet, regardless of who made it.

The FDA version has a stabilizer engineered to manage that problem. Research grade does not. " ...

HTH
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While this all seems reasonable, how do we square that with 3rd party testing that has shown good stability (retained mass and purity) of refrigerated Tesa up to 21-28 days, and room temp up to 14 days?
 
ltjltj said:
While this all seems reasonable, how do we square that with 3rd party testing that has shown good stability (retained mass and purity) of refrigerated Tesa up to 21-28 days, and room temp up to 14 days?
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The only logical conclusion : the tesamorelin molecule used in gray is slightly different than the in used in newer version of egrifta.
 
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