Reconstituting agent for Cagrilintide
- Thread starter Christine S
- Start date
Thanks for posting!
OK, so what this study is telling us:
"the pancreatic hormone amylin is its high propensity toward the formation of amyloid fibrils"
but
"development of amylin mimetics addresses the propensity of human amylin to form fibrils"
and
"...is known not to be fibrillating"
So for those of you who are still thinking that Cagri is going to give you AD, please read the full text and try to understand correctly what is written there. If not sure, please ask someone who did study in any medical science related field (at least nurse with BNS degree for example).
ImSW1
New_Member
No, that's not how it's supposed to work on the interwebs.
OK, so the system is; I post the most outlandish shit I can think of. Super way out there sort of stuff. I don't provide any research of my own either.
Then, people do all the research for me and then spoonfeed it to me like I'm a 5 year old, since I'm only one level above a functioning idiot. Then I disagree with you and argue forever about how your facts are wrong.
Now, please go back and do your research and let me know the outcome, my internet life depends on it!
PS. Yes, the multiple emoji are a requirement. I don't make the rules, I just follow them.
Next you are going to try and tell me the Earth IS NOT FLAT!
lalalalalalalalalalalalalalalalalalalalal I can't hear you
...... 
You made the rulesImSW1
New_Member
Dammit, you know the system as well. Easy enough, quickly change the subject.Next you are going to try and tell me the Earth IS NOT FLAT!
lalalalalalalalalalalalalalalalalalalalal I can't hear you
Yeah, but what about the sun's rotation?Checkmate!
This paper does not provide 'proof' that cagri will not form fibrils. The researchers chose the combination of most stable and most efficacious of the various derivatives studied; still, the stability was measured over the course of 45h, which is a bit shorter than we are storing our peps; and there is not solid evidence in this paper that the compound can remain stable over time at higher pH, only that it is initially soluble.
While hysteria over fibrils may be overblown, complete dismissal that there could be risks (which could be increased when not produced, reconstituted, and stored precisely in the manner developed by the original researchers) is a bit flippant for me.
I think this thread has gone too far from the original topic, I admit its partly my fault, but I could not ignore the claims that Cagri gives you AD.
I can only conclude that there is no scientific evidence that Cagri causes AD.
For those people who disagree, my advice is: don't take it
That's it, really simple.
I can only conclude that there is no scientific evidence that Cagri causes AD.
For those people who disagree, my advice is: don't take it
That's it, really simple.
No one has said cagri gives you AD (except maybe some hysterical person on reddit). It doesn't. Could cagri possibly contribute to a process that has been associated with developing AD? Maybe. I agree with you it seems unlikely. And I agree even more that everyone should inform themselves and make the decision that suits them.
JohnnyGobbs
New_Member
This is kinda how I interpreted it. It’s borderline sketchy per the PH and fibrils. I don’t love that they’re going out of their way to not reconstitute like we typically do but that’s all I takeaway from it.
AnnSolo771
New_Member
Interesting article synthesizing several studies/research articles re what Cagri does/does not do, when and how, or not. FYI & R.
I do just want to point out this isn't exactly an article, but rather a post made in another forum. While this person has a medical background, they have not directly researched (using the actual meaning of the word!) cagri. While the info is helpful, in my opinion there are a lot of unknowns out there and this writeup makes hypotheses sound like facts. So I would just say read it with that in mind!
not sure about the medical background, with this style of writing its not even on a diploma level
and im not even talking about not understanding basic facts which I highlighted here many times and yet some still not understand it
for me this topic was closed already and still someone is coming with these baseless claims, confusing amylin with cagri - two related but different coumpounds
Conflating amylin and cagrilintide is not the issue here. Many peptides can form amyloid fibrils, including cagrilintide and semaglutide, which is for some reason rarely discussed (although it is discussed in the CagriSema patent filing). The issue is whether or not this poses a risk to anyone injecting them, and nothing I've read said this is an open and shut topic, because it is impossible to know precisely how these peptides act in the body post injection.
I was referring to the post by @AnnSolo771, yours response to that is much more rational, sorry for confusion. However there was already posted research which says amylin mimetics (such as cagri) do not form amyloid fibrils...
But I guess there always will be a group of people who think covid vaccine contain chips etc.
Amyloidogenicity of peptides targeting diabetes and obesity
Since the discovery of insulin, a century ago, the repertoire of therapeutic polypeptides targeting diabetes - and now also obesity - have increased s…
www.sciencedirect.com
And I'm vaccinated, tyvm
This is science, not conspiracy.
you see if we talk science it must be very specific and relevant
if we use the same logic from the article you post, I can say hay fewer OTC medication can cause children becoming drug addicts., because it contain pseudoephedrine which molecule is almost the same as methamphetamine
if we use the same logic from the article you post, I can say hay fewer OTC medication can cause children becoming drug addicts., because it contain pseudoephedrine which molecule is almost the same as methamphetamine
noteablequotable
Research Enthusiast
The Reddit post was complex but also pretty clear about why this is a nothin burger:
- NN designed Cagrilinitide such that it does not easily form fibrils
- In order to get Cagrilinitide to form fibrils it was subjected to a great deal of stress. They increased its PH, but also raised it's temp and put it in a centerfuge for 45 hours.
- Fibrils do not teleport, and will not magically end up in your brain.
So, even if you fail to control temp and pH, as long as you avoid putting it in a centerfuge you shouldn't have to worry about fibrils.
There doesn't seem to be much to worry about here because while Cagrilinitide can form fibrils, it takes a lot of deliberate effort to produce that result.
Christine S
New_Member
Its not fear mongering, it's called research. If there is a chance that the peptide can degrade in the wrong solution, I would like to know. That is why I am asking here. I am not finding the answers in my research and I know there are a lot of knowledgeable folks in this forum. Am I wrong?
nonyabizznez
Member
You weren't being accused of fear mongering. The Reddit thread was... Hopefully that hyper sensitivity stays there
