Reflux and the GLP Matrix~

[Stace_wow]

Hi everyone,

Don't mind mind super simplified title, I have a complex set of GI issues (before taking tirz) and I am looking for some others experience and guidance and suggestions 🙂

I have had GERDS for almost 2 decades, believe it's been caused/made worse by a large hiatal hernia just above the junction of my esophagus and stomach. In my younger years, I would just take Omeprazole, and not adjust any of my habits, but for the last five or six years, I have been more interested in changing my behaviors around eating to help assist my body the best I can. I also have no gallbladder, had emergency removal about 3 years ago, then I subsequently developed Diverticulosis. Needless to say, my stomach and digestion is trashed. I have a myriad of things I do, and have done to minimize the impact and assist when I sleep because that is the worst time for me. I will get sick in the middle of the night, vomit, and not be able to settle my stomach back down for a while. I take a max dose of Omeprazole, I add a Famotidine dose (mainly for PMS/PMDD relief), I use baking soda for quick relief and Gaviscon when I lay down. I do not eat before bedtime. I stop about 3/4 hours before bed, and this was all working until this last week.

Diet is 80% clean, I cook almost all my meals at home and I stay away from fast food. I eat low fat, high fiber, high protein, very little red meats (they don't sit well) almost no prepackaged foods (again, they never sit well in my stomach) & I am very focused on micros, including probiotics. I eat yogurt daily, and take ox bile once a day and I am on my 4th week of 7.5mg shot (for reference) I plan to titrate up Saturday....

I know the GLP causes delayed gastric emptying, and I have made adjustments to my eating cause of it, but its not enough or I am missing something.

Has anyone experienced anything similar and been successfully able to reduce gastric disruption by changing awake habits?
Has anyone used BPC to reverse/help a bad tummy successfully?
Any help, guidance or anything...even if its seemingly small, I'll take it!

**I do realize my issues are complex, but they have been well managed before, & I trust there is a solution that is lifestyle based....I'd really like to stop all the heartburn meds or lower them without suffering

 

[headward]

You might want to look into KPV. It is supposed to help gut issues.

 

[Stace_wow]

Looking at it now. Thank you!!

 

[rkbleddyn]

I have really bad GI issues with Tirz. I had zero GI issues before starting Tirz.

I was so sick, even on 2.5mg for 4 weeks, I had to lower the dose to 1.5 and I still have GI issues at 7 weeks. But they are less. So the only thing that worked for me is lowering my dose and time. I also take oral BPC-157 and even that does not help. Before Tirz, BPC-157 had my digestive system working about as perfect as could be hoped for.

For really bad reflux, Famotidine and some capsules I bought named Khlep (Sodium Alginate) helps some. Temporarily.

Good luck, for me, nothing except taking a baby dose and passing of time on Tirz really helps. I've pretty much decided that the constipation on Tirz will never completely go away until I get off it.

It's the GLP-1 slowing of gastric emptying. Humans are not Gila monsters and food setting in your gut for 2 days is totally unnatural for humans.

 

[Stace_wow]

Yeah, I absolutely agree about the food sitting in our stomachs. I have had all my issues pre-tirz. I have responded well to the GLP with no side effects. I use the Sodium Alginate too (Gaviscon) and it was saving my life when my meal timing was off....Thanks so much for your response 🙂

I use Miralax almost daily, which may help you? I don't have any history of constipation, but the Miralax helps things move more smoothly imo, a total lifesaver for me cause it doesn't cause any gastric upset or pain, it just works...

 

[lessthanhalf]

Hi everyone,

Don't mind mind super simplified title, I have a complex set of GI issues (before taking tirz) and I am looking for some others experience and guidance and suggestions 🙂

I have had GERDS for almost 2 decades, believe it's been caused/made worse by a large hiatal hernia just above the junction of my esophagus and stomach. In my younger years, I would just take Omeprazole, and not adjust any of my habits, but for the last five or six years, I have been more interested in changing my behaviors around eating to help assist my body the best I can. I also have no gallbladder, had emergency removal about 3 years ago, then I subsequently developed Diverticulosis. Needless to say, my stomach and digestion is trashed. I have a myriad of things I do, and have done to minimize the impact and assist when I sleep because that is the worst time for me. I will get sick in the middle of the night, vomit, and not be able to settle my stomach back down for a while. I take a max dose of Omeprazole, I add a Famotidine dose (mainly for PMS/PMDD relief), I use baking soda for quick relief and Gaviscon when I lay down. I do not eat before bedtime. I stop about 3/4 hours before bed, and this was all working until this last week.

Diet is 80% clean, I cook almost all my meals at home and I stay away from fast food. I eat low fat, high fiber, high protein, very little red meats (they don't sit well) almost no prepackaged foods (again, they never sit well in my stomach) & I am very focused on micros, including probiotics. I eat yogurt daily, and take ox bile once a day and I am on my 4th week of 7.5mg shot (for reference) I plan to titrate up Saturday....

I know the GLP causes delayed gastric emptying, and I have made adjustments to my eating cause of it, but its not enough or I am missing something.

Has anyone experienced anything similar and been successfully able to reduce gastric disruption by changing awake habits?
Has anyone used BPC to reverse/help a bad tummy successfully?
Any help, guidance or anything...even if its seemingly small, I'll take it!

**I do realize my issues are complex, but they have been well managed before, & I trust there is a solution that is lifestyle based....I'd really like to stop all the heartburn meds or lower them without suffering

The only thing I did not see you mention is changing the angle of your bed with some bricks under the feet at the head of the bed. My mother has a very similar hiatus hernia.

The GLP drugs are very likely to help once you start losing weight, by reducing overall intra abdominal pressure pushing the stomach and its valve upwards, maybe even allowing it to fall back to where it should be. But you might have to put up with worse symptoms in the meantime from the drugs that typically reduce gastric emptying and make reflux worse.

 

[FartfulCodger]

It sounds like you've tried so many things, including my personal favorite Omeprazole. The only other thing I can think of is to make sure you're sleeping on your left side. It might also help to elevate your torso a bit, i.e. keeping your stomach "downhill" from your esophagus. Perhaps you can sleep on your back in a recliner chair, or create a makeshift recliner in your bed with stacked pillows.

Other people swear by digestive enzymes, combinations of Protease, Papain, Cellulase, and some other "-ases".

 

[Stace_wow]

The only thing I did not see you mention is changing the angle of your bed with some bricks under the feet at the head of the bed. My mother has a very similar hiatus hernia.

You know, my BF has one of those really cool beds that inclines and when I think of it….I rarely have these effects when I sleep at his house! I’m gonna do this, thank you!

 

[Stace_wow]

Omeprazole is usually my go to, also! I will try adding in the enzyme ases…

Thank you!