Regret switching??

[Kang-Thang]

Curious if anyone has regretted switching off of tirzepatide in favor or retatrutide. I have seen reports of people switching back to tirzepatide, but not sure how common it is.

I am hitting a stall with tirzepatide, but I have not given up on it, using 15mg/ every six days. I am interested in retatrutide, but not sure if it is worth the investment for me.

 

[Justagirlandherdog]

Hi, I tried retatrutide for 5 weeks, came from tirzepatide 7,5mg. But it wasn't for me no supression and the foodnoise was hitting hard again. I'm back on tirz, and consider to take Cagrilintide with it.

 

[BioDad]

I was reading a paper published about a month ago, "Appetite, eating attitudes, and eating behaviours during treatment with retatrutide in adults with type 2 diabetes: Results of a phase 2 study".

From memory, the short version is, 275 type 2 diabetics split into a control group, a dulaglutide group (1.5mg), and four retatrutide groups (0.5, 4, 8 and 12mg). I think it ran 36 weeks.

Researchers found that it took at least 4mg of retatrutide to have an impact on appetite scores (there were two tools they used - Appetite Visual Analogue Scale and Eating Inventory scores), and a minimum of 8 weeks in some participants.

Most of the findings were similar to tirzepatide (reduction in disinhibition, cravings for certain foods), but something unique to retatrutide had to do with cognitive restraint from eating, which went a little beyond mere appetite suppression.

The authors did state that results were a little less consistent than with dulaglutide, which seems to be the user experience here, too.

 

[MsGizmo]

If food noise is the issue maybe try micro dosing sema?

 

[HumanusExMachina]

I seem to be far more sensitive to reta than the average. I'm at 1.5mg and I hit a hard can't-eat-anymore wall halfway through what would have been a normal portion before. I'm also finding food advertising to be somewhat annoying -- like why are they trying to convince me to eat when I'm not hungry?

Interesting study, by the way. Even though I'm trying to lose weight, I'm far more interested in the other affects of these peptides since I'm pretty much going to be on them for the long-haul.