Restarting Tirz after a break - what dose?

[darkstars]

I was taking tirz from the pharmacy from a year ago until around 8 weeks ago.

I am soon to receive delivery of T60 (as I was up to 15mg doses before).

I am thinking to start with 5mg for the first couple of weeks to see how I tolerate it before going back up through 7.5,10 each month as necessary. Is this an ok plan or should I be starting lower than 5mg?

Thanks!

 

[UghItsStupidNIHateIT]

My uncle started back at 7.5 after being off for four months. This ended with two enemas, being naked on the side of the road, and the best family reunion story in living memory. I would start at 2.5.

 

[Sasquatch]

I took a month off recently and started back at 5mg. First time it took no more than three days to feel effects. So I titrated up quickly. Probably 10mg the next week.
Fucking frustrating. Didn't really feel anything until I got back to 15mg.
If you've followed or read my posts, it's actually 19.5mg weekly. Dose on Thursday(small), and a big dose on Saturday. (I'm still not loosing because I get fed too much) Zoo-keeper🙄

Disclaimer - only you would know how you responded,, first go. Anticdotally, all I've read, the second go is less responsive. There's 7% shown in studies, that it doesn't work at all, to begin with. Give yourself enough time to be sure things are OK before going to the next step.

 

[lessthanhalf]

One area where tolerance is a real thing with GLP drugs is nausea and vomiting and slowed gastric emptying, so it is possible over 8 weeks to have lost some tolerance. Depends a bit also on what side effects you had when previously increasing doses of tirz.

The lowest risk method is obviously to start at low doses and gradually build back up. If you want to increase doses more rapidly than standard, the safest way to do it is with smaller more frequent doses. That way each peak in blood levels will be lower, and it will only take 2 or 3 days for blood levels to drop back to pre dose levels, so twice a week or second day dosing. 2.5mg twice a week as a restarting dose is less likely to cause problematic side effects than 5mg once a week. This also enables small increases in dose more often, so 2.5 to 3.5 mg twice a week in a week or two , but if you do start getting side effects it is important to slow down or stop increases in dose until things settle. once you get to the weekly dose you want you can gradually increase one half of the doses while decreasing the other half until you get back to once a week. But you need to check out glp plotter before doing this so you understand the drug pharmacokinetics, and doing this without previously being on GLP drugs is not such a great idea. I used this process to get from 1mg to 15mg/week in a month when I swapped from semaglutide to tirz. In general the faster you push dose increases the higher the chance of unpleasant side effects.

 

[Ajejebrazorf]

My uncle started back at 7.5 after being off for four months. This ended with two enemas, being naked on the side of the road, and the best family reunion story in living memory. I would start at 2.5.

gosh, I'm dying LOL

 

[MeanSteve]

I was taking tirz from the pharmacy from a year ago until around 8 weeks ago.

I am soon to receive delivery of T60 (as I was up to 15mg doses before).

I am thinking to start with 5mg for the first couple of weeks to see how I tolerate it before going back up through 7.5,10 each month as necessary. Is this an ok plan or should I be starting lower than 5mg?

Thanks!

You may be ok getting back on Tirz, but you should start at a low dose, like 2.5mg for at least 3 weeks. As others have mentioned, what a lot of people notice when stopping and starting Tirz, is that its much less effective the second time around. If you find that you feel as if its "not doing anything", you should discontinue use and move to a different medication. Often times this can be enough to kick start yourself back on your journey. I helped a friend with this issue after taking a four month pause. We did 2 months of low dose Reta and then moved back to Tirz, and she dropped another 12lbs and managed to stay at a lower dose than where she was before.