Reta and Tirz Cycles

[gurbert]

I’m currently on tirzepatide at 5 mg per week, split between Monday and Friday. I’ve lost approximately 6 kg over the past ~45 days. Based on my current supply, I expect to increase to around 10–12.5 mg per week once my current T30 vials are finished.

I’m trying to understand what a more standard or healthier long-term approach would look like, particularly regarding cycling. Specifically:

• Would cycling be preferable compared to continuous dose escalation?
• If so, would an R30 stack make more sense? I currently have an R10 stack, but I’m not sure if that’s sufficient for a full cycle (I believe that would equate to roughly 48 weeks with 400mg).

For context, I currently have approximately 600 mg of tirzepatide and 100 mg of retatrutide on hand. If I were to do a proper retatrutide cycle in the future, my understanding is that I’d need an additional R30 stack (bringing the total to ~400 mg of retatrutide). That said, I’m not planning to start this immediately and would likely complete a full T30 stack first.

I’ve also considered ordering an additional 900 mg of tirzepatide and 300 mg of retatrutide and using shorter retatrutide bursts intermittently, with tirzepatide for maintenance—but I’m unsure whether this is a sound approach or if I’m getting ahead of myself.

I’d appreciate perspective on whether cycling makes sense. If so do I need 600mg of Reta to properly do this or is doing shorter bursts fine?

 

[zpped]

Would you cycle blood pressure or cholesterol medication?

You find the right dose and cadence that brings you to the weight you want to be and you take that for the rest of your life unless something else changes.

 

[woundcarping]

I can’t find sense in much of what you’re proposing.

You’re on 5mg/week now, but once you run out of 30mg vials you’re going to 2-2.5x your dose?

What are you calling a “T30 stack”?

Cycling Tirz or Reta is nonsense for the average person taking it.

Bro?

 

[Abrakebabra]

If you’re losing well why even consider changing your dose let alone the drug? Find a dose that works and stick with it. If Tirz is doing a good job why are you thinking of switching to Reta?

When people refer to stacks they are talking about taking a number of different peptides together. Reta or Tirz on their own aren’t a stack.

To answer the question you asked - no what you are proposing doesn’t make sense in my opinion.

 

[randompersonrandom]

I think anybody who is currently having success with Tirzepatide should stay on Tirzepatide alone EXCEPT if they are having side-effects that they badly want to counter with stacking something else (like the survo fatigue thing) or want to try a stack of a single reta vial JUST to assess if it's something that may work for them in the future because they want to stock it in their freezer, and don't want to find out much later that reta has miserable side-effects for them.

Tirzepatide has been all the way through clinical trials, and has a reasonable amount of long-term safety data. Reta does not yet. It will, but tirz is very effective and there's no good reason to run to reta right away if what you're doing is working.

Mind you, I don't actually care what y'all do and won't argue with anyone who's just so excited to try out all the fun new powders, cause same.

 

[Estarossa19]

I think anybody who is currently having success with Tirzepatide should stay on Tirzepatide alone EXCEPT if they are having side-effects that they badly want to counter with stacking something else (like the survo fatigue thing) or want to try a stack of a single reta vial JUST to assess if it's something that may work for them in the future because they want to stock it in their freezer, and don't want to find out much later that reta has miserable side-effects for them.

Tirzepatide has been all the way through clinical trials, and has a reasonable amount of long-term safety data. Reta does not yet. It will, but tirz is very effective and there's no good reason to run to reta right away if what you're doing is working.

Mind you, I don't actually care what y'all do and won't argue with anyone who's just so excited to try out all the fun new powders, cause same.

Real. Currently on Tirzepatide and having great results but I wanna buy the latest all the cool kids are on 🤣

 

[randompersonrandom]

Real. Currently on Tirzepatide and having great results but I wanna buy the latest all the cool kids are on 🤣

so same. Because I'm "out" about tirz at my ENORMOUS workplace, every person who's on a GLP-1 and NOT out has come to me to tell me all about whatever they're on, and when people say they're on sema, I assume they must not have read up on tirz because who would be on sema when tirz is out there? (yes, I know some people here are on sema and having very good results with few side effects, but all I seem to hear all about in my regular life is about how sema doesn't work very well and has mean side-effects.)

 

[gurbert]

I can’t find sense in much of what you’re proposing.

You’re on 5mg/week now, but once you run out of 30mg vials you’re going to 2-2.5x your dose?

What are you calling a “T30 stack”?

Cycling Tirz or Reta is nonsense for the average person taking it.

Bro?

By T30 stack I mean the standard T30mg x 10 vials that we buy from vendors therefore 300mg of tirz.

Following guidelines you are generally bumping up dose in 2.5mg increments every 4 weeks. I assume I’ll be at 10mg / maintenance dose in 12-16 weeks not when I’m “out of tirz”

 

[gurbert]

Real. Currently on Tirzepatide and having great results but I wanna buy the latest all the cool kids are on 🤣

This is how I feel, I need to justify just buying a Reta30x10vials just because I want to hoard glp1s….but I could just buy double the amount of tirz for the same price and it’s safer….

 

[woundcarping]

By T30 stack I mean the standard T30mg x 10 vials that we buy from vendors therefore 300mg of tirz.

That is commonly referred to as a kit

 

[Habibibi]

I’m currently on tirzepatide at 5 mg per week, split between Monday and Friday. I’ve lost approximately 6 kg over the past ~45 days. Based on my current supply, I expect to increase to around 10–12.5 mg per week once my current T30 vials are finished.

I’m trying to understand what a more standard or healthier long-term approach would look like, particularly regarding cycling. Specifically:

• Would cycling be preferable compared to continuous dose escalation?
• If so, would an R30 stack make more sense? I currently have an R10 stack, but I’m not sure if that’s sufficient for a full cycle (I believe that would equate to roughly 48 weeks with 400mg).

For context, I currently have approximately 600 mg of tirzepatide and 100 mg of retatrutide on hand. If I were to do a proper retatrutide cycle in the future, my understanding is that I’d need an additional R30 stack (bringing the total to ~400 mg of retatrutide). That said, I’m not planning to start this immediately and would likely complete a full T30 stack first.

I’ve also considered ordering an additional 900 mg of tirzepatide and 300 mg of retatrutide and using shorter retatrutide bursts intermittently, with tirzepatide for maintenance—but I’m unsure whether this is a sound approach or if I’m getting ahead of myself.

I’d appreciate perspective on whether cycling makes sense. If so do I need 600mg of Reta to properly do this or is doing shorter bursts fine?

This is not a smart plan. Pick a GLP1 agonist, and stick with it, this isn't that complicated.