Reta Hunger

[DragonOfTheSea]

its okay

All good.

So, I added 2 ml of bac water to 12 mg. I then did another dosage of 10 units (which I think is 150 mcg).

It’s a bit better, I guess. I’m still kind of hungry, which is the annoying part. Addy completely shut it off.

But interestingly, when I eat normally, I’m a person who continues eating even if I can’t eat longer.

Here, I’ve put food or saved it for later (something I’ve literally never done). But yeah, it’s not even like I’m a fat guy. I think the term would be skinny fat, but yeah, I’m hoping it helps. The main reason I wanted Reta vs the others is because of its mental effects.

So I have a few things to say, but before we go any further discussing units and dosage, I want to clarify we are on the same page- are you using 100U 1mL syringes? Also, no matter what, your perceived dosage of 150mcg is definitely not correct, but I can be more exact once we confirm what your unit volume is.

 

[ussop]

A little aggressive, no? They obviously just need a little guidance.

@ussop with the current dilution of your single 12mg vial, I would suggest starting with a 25unit injection- this will give you a 1.5mg dose. It is a bit on the lower side, but will be a significantly larger impact than any mcg amount.

Also, you “think” you did 50-100mcg… how many units did you inject, we can tell you for sure the dosage so that you can properly understand what is and isn’t working.

i used peptide calculator

12 MG

2 ML Water
so here it shows 250 mcg

so that is why i was talking in mcg

now what i am wondering is the increase

or yeah is there a weight loss calculator for reta (im jk i know results vary)

 

[DragonOfTheSea]

i used peptide calculator

12 MG

2 ML WaterView attachment 21578
so here it shows 250 mcg

so that is why i was talking in mcg

now what i am wondering is the increase

or yeah is there a weight loss calculator for reta (im jk i know results vary)

That calculator is correct, your previous calculations do not seem so. But either way we still need to know how many units are on your syringe. Are you using a 100U 1mL syringe? Like the 3rd one in the screen shot you posted?

 

[ussop]

That calculator is correct, your previous calculations do not seem so. But either way we still need to know how many units are on your syringe. Are you using a 100U 1mL syringe? Like the 3rd one in the screen shot you posted?

Correct the 3rd one.

 

[txnj11]

I recently started taking Reta, and I’m noticing a significant increase in hunger, specifically intense cravings for sweets.

This is unusual for me because I also take Adderall, which typically suppresses my appetite.

Additionally, I am on Keppra and Lamotrigine. Does anyone have advice on managing these cravings or insight into how these medications might be interacting?

I had a similar experience. I was on tirzepatide (Mounjaro) for a year, then experimented with retatrutide for a month. During that time, I noticed a higher heart rate, minimal hunger suppression, and GI issues. After switching back to tirzepatide, everything returned to baseline.

 

[DragonOfTheSea]

Correct the 3rd one.

Ok thank you for the clarification. SO:

With you dilution- 2ml into a 12mg vial, your concentration is 6mg/ml.
When you said you injected 10 units, that means you took a .6mg (or 600mcg) dose, not 150mcg.

Think back to what the volume of your other doses were, up to now, and make these adjustments so that you can properly (both for yourself and for anyone wanting to help you) describe accurately what your dosage history has been.

 

[lessthanhalf]

I recently started taking Reta, and I’m noticing a significant increase in hunger, specifically intense cravings for sweets.

This is unusual for me because I also take Adderall, which typically suppresses my appetite.

Additionally, I am on Keppra and Lamotrigine. Does anyone have advice on managing these cravings or insight into how these medications might be interacting?

There is a known interaction between GLP drugs and adderall, although it may not be listed as an interaction , it has been seen in animal studies. In the same way that GLP's make food less rewarding , they can reduce the effect of stimulants by direct action on the relevant brain cells.
Most interactions with GLP drugs are caused by slowing down absorption of other drugs by slowed gastric emptying.
I have not seen it mentioned for reta, but it is a GLP-1 agonist effect so should apply.
I noticed that as soon as I started taking ozempic I could no longer feel I had taken my dose of dexamphetamine, and tirzepatide has the same effect, effectively lowers the dose.
You mention you are taking it for possible mental benefits so hopefully this effect is not a big issue.
That being said the doses of reta you describe taking are so microscopic they may not be enough to do anything much. And might be placebo effects, hard to say.
But if it is reducing the effect of adderall, that could explain the increased sweet hunger. And people do sometimes complain about this happening when starting reta, due to the glucagon agonism, but it usually goes away after a while.
Not familiar with Keppra so cannot comment on if it has interactions, never heard of there being issues with lamotrigine. But if you are not sure look it up , it is the kind of thing that must always be checked if starting a new drug, and usually gets done by your doctor or their computer program, there are plenty of online resources or ask chatgpt, it's pharmacology is pretty good.

 

[elevator13]

i used peptide calculator

12 MG

2 ML WaterView attachment 21578
so here it shows 250 mcg

so that is why i was talking in mcg

now what i am wondering is the increase

or yeah is there a weight loss calculator for reta (im jk i know results vary)

I believe the example doses given by the calculator are arbitrary - those amounts are not relevant to retatrutide specifically.

1ml = 100 units
1mg = 1000mcg

So, 10 units at a dilution of 12mg/2ml:
1ml=6mg
0.1ml=0.6mg
You took 600mcg. That’s a fine test dose to see if you tolerate the drug. The next step is an earnest dose of 1mg or 1.5mg. I personally started at 2.5mg.

16 units will give you 960mcg.
25 units will give you 1.5mg.
33 units will give you ~2mg.

 

[ussop]

Ok thank you for the clarification. SO:

With you dilution- 2ml into a 12mg vial, your concentration is 6mg/ml.
When you said you injected 10 units, that means you took a .6mg (or 600mcg) dose, not 150mcg.

Think back to what the volume of your other doses were, up to now, and make these adjustments so that you can properly (both for yourself and for anyone wanting to help you) describe accurately what your dosage history has been.

so double to 500 mcg?

 

[DragonOfTheSea]

so double to 500 mcg?

I don't think we're on the same page..

From what you have said, you have already dosed 600mcg on your last dose, in addition to whatever other doses you have done before then.

Do you have any record at all of when you took each of your does, and how many units you took at each of those doses? If so, can you provide that info? Do not provide what you think you dosed in .mcg, please provide what you dosed in units.

 

[ussop]

I believe the example doses given by the calculator are arbitrary - those amounts are not relevant to retatrutide specifically.

1ml = 100 units
1mg = 1000mcg

So, 10 units at a dilution of 12mg/2ml:
1ml=6mg
0.1ml=0.6mg
You took 600mcg. That’s a fine test dose to see if you tolerate the drug. The next step is an earnest dose of 1mg or 1.5mg. I personally started at 2.5mg.

16 units will give you 960mcg.
25 units will give you 1.5mg.
33 units will give you ~2mg.

I’m a bit confused as well, Please pardon me.



Elevator said this

With you dilution- 2ml into a 12mg vial, your concentration is 6mg/ml.
When you said you injected 10 units, that means you took a .6mg (or 600mcg) dose, not 150mcg.

How is it 600? I’m sorry, I’m a bit lost. To be honest, I’m not really sure at all.

 

[elevator13]

I believe the example doses given by the calculator are arbitrary - those amounts are not relevant to retatrutide specifically.

I’m a bit confused as well, Please pardon me.



Elevator said this

How is it 600? I’m sorry, I’m a bit lost. To be honest, I’m not really sure at all.

A unit is equal to 0.01 milliliters. There are 100 units in a whole milliliter, as shown on the syringes you mentioned you have.

You used 2 mL or 200 units of bacteriostatic water to reconstitute your 12 milligram vial of reta powder. That means your reta is now dissolved at a concentration of 12 milligrams per 200 units.

Therefore, 100 units, half the vial, would contain half of the total drug - 6 milligrams.
That means that one tenth of that, ten units (0.1mL), would include one tenth of 6 milligrams - which is 0.6 milligrams. You can also call that 600 micrograms since there are 1000 micrograms in a milligram.

Going forward, I would advise forgetting the microgram terminology and referring to reta doses in milligrams since that is usually what effective doses are measured in.

Is there anything we can still help you understand?

 

[DragonOfTheSea]

I believe the example doses given by the calculator are arbitrary - those amounts are not relevant to retatrutide specifically.

Yes the example doses given are arbitrary, but the calculation of concentration on the calculator are correct. Forget about the mcg dosages and focus on understanding the concentration of the calculation it is telling you.

 

[Birdie]

I recently started taking Reta, and I’m noticing a significant increase in hunger, specifically intense cravings for sweets.

This is unusual for me because I also take Adderall, which typically suppresses my appetite.

Additionally, I am on Keppra and Lamotrigine. Does anyone have advice on managing these cravings or insight into how these medications might be interacting?

I started Reta while still on Sema. I transitioned to just Reta two months ago to eliminate some of the side effects from the Sema. Since that time, I have been adjusting my dose and monitoring food noise in the Shotsy app trying to find the sweet spot with a plan for long term use. I do consume sweets more, but I attributed that to my new stance that no food is off limits thanks to the stifling of the food noise.

I will add that I am a candymaker and baker in my free time, but I seldom crave those things. The other day I wanted a chocolate milkshake, so I had a small one and could not finish it. The peptides allow me to stop when I am satisfied. That said, I do tend to eat very healthy food (always did, just too much of it) and I have never been a dessert eater. I am actually enjoying the control I have now which allows me to enjoy things I wouldn't have thought I "deserved" before. This stuff is really helping me have a much healthier relationship with food (and myself).