Reta X Cagrilintide

[zpped]

So is there a distinction between the reta not working and just not providing the appetite suppression?
With better eating habits and strength training, could reta still have the benefits of the 2 other agonist even if the appetite suppression isn't an issue?

Yes there is a distinction. Appetite and Satiety are separate functions. I get hungry and then I get full.

 

[Waclive]

Yes there is a distinction. Appetite and Satiety are separate functions. I get hungry and then I get full.

I understand they're two separate functions in the body.

I'm asking if the people saying it doesn't work is saying that based solely on the presence of food noise or if it's actually working by causing insulin sensitivity and losing body fat but not suppressing food noise.

 

[cygnus]

So is there a distinction between the reta not working and just not providing the appetite suppression?
With better eating habits and strength training, could reta still have the benefits of the 2 other agonist even if the appetite suppression isn't an issue?

Improved insulin sensitivity, nutrient partitioning, and signal for hepatic fat burn would still happen absent the "hunger" signal associated primarily with GLP-1 and thus still be working.

Cagri hitting on Amylin does make me think that Eli, Novo, or Pfizer will probably end up making a quad agonist that covers GLP-1/GIP/Glucagon/Amylin as it seems like a no-brainer given CagriSema is going to fare well and some of the vendors starting to mix reta and cagri.

CN vendors, figure out an oral MK677/orforglipron combo.

 

[Waclive]

Improved insulin sensitivity, nutrient partitioning, and signal for hepatic fat burn would still happen absent the "hunger" signal associated primarily with GLP-1 and thus still be working.

Cagri hitting on Amylin does make me think that Eli, Novo, or Pfizer will probably end up making a quad agonist that covers GLP-1/GIP/Glucagon/Amylin as it seems like a no-brainer given CagriSema is going to fare well and some of the vendors starting to mix reta and cagri.

CN vendors, figure out an oral MK677/orforglipron combo.

Thank you. That is exactly what I was looking for!

 

[Nextlevel]

I'll spout my typical "be careful of the pH level of cagri" schpeil. Don't just mix it with BAC and get the pH down to 4 ideally, or within 3.5-4.5.

How do you test the PH levels and get it higher or lower as needed? I have been losing weight with Reta 3mg (started at 1mg, then 2mg and now 3mg as I am slow rolling it) but I've heard a little cagri with reta goes a long way.

 

[CNCCurrency]

How do you test the PH levels and get it higher or lower as needed? I have been losing weight with Reta 3mg (started at 1mg, then 2mg and now 3mg as I am slow rolling it) but I've heard a little cagri with reta goes a long way.

At pH 7.4 (closer to physiological pH), cagrilintide degrades much faster, with one study showing nearly 45% degradation in 10 days compared to minimal degradation for a newer analog.

• Improved Analogs: Researchers are developing next-generation amylin analogs, like the related Compound C, which show superior stability at pH 7.4, allowing for potential co-formulation with GLP-1 drugs.

 

[thatkatmat]

Amateur hour here. I have PH strips and AA ordered and have BAC and just need clarification on what others do please.

Is it the reconstructed final vial that is tested and adjusted to get to the 4ish pH level or is it the mixture of AA/BAC that needs to be at a decent level BEFORE adding to Cagri peptide.

Thanks

I think it's the Bac/AA mixture...Anyone care to chime in?

 

[RadicalCrimson]

I think it's the Bac/AA mixture...Anyone care to chime in?

Some people have reported a 4pH reconstituted Cagri with just BAC water (pre-buffered), so IMO you should definitely test that first before adding anything.

 

[StraightCancer]

You will hear different things from different people. This is my experience I have been
experimenting with tirezepatide for almost 15 months and up to 12.5 mgs. I switched to
Reta and started at 5 mgs and had almost no appetite suppression for over a month. I moved up to 7 mgs and had a little suppression so I added .5mgs of cagri and wow
what a difference. Be careful with cagri it’s a very strong suppressant. If you over do it
you aren’t gonna like the feeling. All in all I have lost 108 pounds since I started. This
is my experience take from it what you will. I also know people that are using Reta and
tirz together .

Thank you for this.

Just an update for everyone, I hit a weight plateau after losing 70lbs in 3 months so I decided to take a break from Reta and get my metabolism back to normal.

I have only rebounded about 7lbs in the last 3-4 weeks since I have been off Reta which is healthy if anything.

That being said, I do plan on buying 10mg cagri to add to a stack or use on its own for purely appetite suppression in the future.

 

[Wallydog]

I'll spout my typical "be careful of the pH level of cagri" schpeil. Don't just mix it with BAC and get the pH down to 4 ideally, or within 3.5-4.5.

I know this is an old thread and post but can you expand on the pH issue with Cagri? I've used it before to jump start stalled weight loss when using 15mg tirz and didn't notice anything unusual with the solubility or the injection. Actually helped move some pounds off. Thanks.

 

[Main75]

Are you losing ~1lb per week? If so, don't do anything. If not, add more reta. Why do you want to make it complicated?

Well …I am at 12 mg Reta and need more food noice support…. What would you add ? More Reta ? Or cagri

 

[woundcarping]

Well …I am at 12 mg Reta and need more food noice support…. What would you add ? More Reta ? Or cagr

Right now I’d add Tirz, I even took a support dose when I was working through my weight bounce/getting my Reta dose dialed in/fixing to take a weekend trip. Short term problem, short term solution.

If I got to the point I didn’t want to move up on Reta I’d probably go through the rest of my compounded Tirz, then mix some Sema to stack with, probably around .5-1mg/week. If I couldn’t find a happy dose, staying on the same GLP1 receptor, I’d go to cagri.

I’m fine with increasing my Reta dose until sides become a problem. I also split dose 2x weekly so my peaks are lower than once weekly.

 

[Main75]

Thank you for this.

Just an update for everyone, I hit a weight plateau after losing 70lbs in 3 months so I decided to take a break from Reta and get my metabolism back to normal.

I have only rebounded about 7lbs in the last 3-4 weeks since I have been off Reta which is healthy if anything.

That being said, I do plan on buying 10mg cagri to add to a stack or use on its own for purely appetite suppression in the future.

Right now I’d add Tirz, I even took a support dose when I was working through my weight bounce/getting my Reta dose dialed in/fixing to take a weekend trip. Short term problem, short term solution.

If I got to the point I didn’t want to move up on Reta I’d probably go through the rest of my compounded Tirz, then mix some Sema to stack with, probably around .5-1mg/week. If I couldn’t find a happy dose, staying on the same GLP1 receptor, I’d go to cagri.

I’m fine with increasing my Reta dose until sides become a problem. I also split dose 2x weekly so my peaks are lower than once weekly.





View attachment 16287

Really don’t know about the “upper limit” of RETA outside of the tested doses In The studies of which I am at the top tested dose. Side effects super minimal unless a cheat day had wine or beer or sweets ….all three make me feel uneasy ..even through part of the next day.
I don’t believe that any major gastric slowing is currently happening…definitely does not feel like it did when I started , wether that is my body getting used to everything I throw at it (possible at 12mg for three weeks now) . I’ve been chasing dosage up trying to get the feeling and effect that I had two months ago

 

[zpped]

Well …I am at 12 mg Reta and need more food noice support…. What would you add ? More Reta ? Or cagri

You didn't answer the first question. This isn't a "don't feel hungry drug" it's a "lose weight" drug

 

[Main75]

Trying figure out which question you’re referring to?
Yes, Reta is a weight loss drug and yes it has appetite suppression integrated into it as one of the three effects..
explain you take if I overlooked something in this statement.
The hunger part was effective at lower doses for me…after getting to 12mg that aspect of Reta seems to have become less effective for me. My hope is that the other elements are working in the background, but by scale results alone I have been stalled for 2 months.
This is an attempt to gain more insight as to why this may be happening and to learn if others have had similar experiences . Also what they did to have success with their goals

 

[zpped]

Trying figure out which question you’re referring to?
Yes, Reta is a weight loss drug and yes it has appetite suppression integrated into it as one of the three effects..
explain you take if I overlooked something in this statement.
The hunger part was effective at lower doses for me…after getting to 12mg that aspect of Reta seems to have become less effective for me. My hope is that the other elements are working in the background, but by scale results alone I have been stalled for 2 months.
This is an attempt to gain more insight as to why this may be happening and to learn if others have had similar experiences . Also what they did to have success with their goals

Are you losing ~1lb per week? Was the question. You have now answered it (assuming by stalled for 2 months, you mean haven't lost any weight at all). Now, are you measuring your food and counting calories? Have you been on the 12mg the entire 2 months?

 

[Main75]

Been bounce couple up couple down at 280 -283 since call it 7 weeks . Definitely a different work from pre Christmas . Not complaining….just trying to sort it out … stopping tessa and ipa for the next month is my first step as it was one thing that was added during this time l…
12mg for 3 weeks
Was at 5 mg pre Christmas ….sorta chaseing the great results of the first 2 and a half month of Reta

It was a change like a light switch not a slow change … what changed , new Reta supply and added Tess and ipa…

 

[Chopper]

Been bounce couple up couple down at 280 -283 since call it 7 weeks . Definitely a different work from pre Christmas . Not complaining….just trying to sort it out … stopping tessa and ipa for the next month is my first step as it was one thing that was added during this time l…
12mg for 3 weeks
Was at 5 mg pre Christmas ….sorta chaseing the great results of the first 2 and a half month of Reta

It was a change like a light switch not a slow change … what changed , new Reta supply and added Tess and ipa…

I can say that while I run Tesa/Ipa alongside Reta/Tirz, The scale doesn't really go down and the Ipa feels like it somewhat overrides the "suppression" effect. All that said I do seem to lose fat in my stomach area while taking those albeit not as much as I'd like. Also, when I am off those the weight seems to resume dropping fairly easily.

 

[zpped]

Been bounce couple up couple down at 280 -283 since call it 7 weeks . Definitely a different work from pre Christmas . Not complaining….just trying to sort it out … stopping tessa and ipa for the next month is my first step as it was one thing that was added during this time l…
12mg for 3 weeks
Was at 5 mg pre Christmas ….sorta chaseing the great results of the first 2 and a half month of Reta

It was a change like a light switch not a slow change … what changed , new Reta supply and added Tess and ipa…

So you've gained weight from the GH related peptides, taking a known hunger increaser (Ipa), and rapidly accelerated your reta dosing in a misguided attempt to achieve a side effect. You should really slow down and understand what you're doing.

 

[bluefootedboobie]

Been bounce couple up couple down at 280 -283 since call it 7 weeks . Definitely a different work from pre Christmas . Not complaining….just trying to sort it out … stopping tessa and ipa for the next month is my first step as it was one thing that was added during this time l…
12mg for 3 weeks
Was at 5 mg pre Christmas ….sorta chaseing the great results of the first 2 and a half month of Reta

It was a change like a light switch not a slow change … what changed , new Reta supply and added Tess and ipa…

I just started a thread in the retatrutide subforum about this, I've been going through exactly what you have been.

https://glp1forum.com/threads/retatrutide-plateau-adaptation-or-resistance-to-reta.11660/

Same as you, the change was more like a light switch than a slow change. After about three months, the effects of reta just almost stopped. Of the three reta receptors:

• GLP-1 receptor (glucagon-like peptide-1 receptor) — helps regulate appetite, slow gastric emptying, enhance insulin secretion, and promote satiety.
• GIP receptor (glucose-dependent insulinotropic polypeptide receptor, also called gastric inhibitory polypeptide receptor) — supports insulin release and contributes to metabolic regulation.
• Glucagon receptor (GCG receptor) — influences energy expenditure, fat metabolism, and other processes like increasing lipolysis.

I'm near certain it's my GLP-1 receptors that have stopped responding. The gastric emptying slowdown has ceased and the appetite regulation and satiety effects have virtually completely gone away.

 

[Main75]

I can say that while I run Tesa/Ipa alongside Reta/Tirz, The scale doesn't really go down and the Ipa feels like it somewhat overrides the "suppression" effect. All that said I do seem to lose fat in my stomach area while taking those albeit not as much as I'd like. Also, when I am off those the weight seems to resume dropping fairly easily.

This is what I am guessing at the moment too …day 5 off Tessa/ipa. Hoping to see a little scale movement next week .
Obvious inexperience but did not expect full stop on weight loss ….like light switch ..
240-250 target so 30-40 more… back to quick and strong not just big

 

[Main75]

So you've gained weight from the GH related peptides, taking a known hunger increaser (Ipa), and rapidly accelerated your reta dosing in a misguided attempt to achieve a side effect. You should really slow down and understand what you're doing.

that’s goal of learning on the forum.
Reading the clinicals ect. …cold feet has been the only side effect thus far..
I read up ipa and understood water and hunger sides… but hoped muscle maintenance would be worth a slower weight loss…did not expect a full stop

 

[Main75]

I just started a thread in the retatrutide subforum about this, I've been going through exactly what you have been.

https://glp1forum.com/threads/retatrutide-plateau-adaptation-or-resistance-to-reta.11660/

Same as you, the change was more like a light switch than a slow change. After about three months, the effects of reta just almost stopped. Of the three reta receptors:

• GLP-1 receptor (glucagon-like peptide-1 receptor) — helps regulate appetite, slow gastric emptying, enhance insulin secretion, and promote satiety.
• GIP receptor (glucose-dependent insulinotropic polypeptide receptor, also called gastric inhibitory polypeptide receptor) — supports insulin release and contributes to metabolic regulation.
• Glucagon receptor (GCG receptor) — influences energy expenditure, fat metabolism, and other processes like increasing lipolysis.

I'm near certain it's my GLP-1 receptors that have stopped responding. The gastric emptying slowdown has ceased and the appetite regulation and satiety effects have virtually completely gone away.

Like a light switch …not subtle not just slowed . 5 days off ipa /tessa and will be looking to get off-1 baseline test after a month as some had suggested .. targeting 240-250 as primary goal not muscle growth but maintenance

 

[StraightCancer]

So is there a distinction between the reta not working and just not providing the appetite suppression?
With better eating habits and strength training, could reta still have the benefits of the 2 other agonist even if the appetite suppression isn't an issue?

Yes imo. My appetite suppression isn’t nearly as close as what it was when I started Reta. Regardless of dosage.

That being said, weight is still dropping.

 

[BioDad]

I just started a thread in the retatrutide subforum about this, I've been going through exactly what you have been.

https://glp1forum.com/threads/retatrutide-plateau-adaptation-or-resistance-to-reta.11660/

Same as you, the change was more like a light switch than a slow change. After about three months, the effects of reta just almost stopped. Of the three reta receptors:

• GLP-1 receptor (glucagon-like peptide-1 receptor) — helps regulate appetite, slow gastric emptying, enhance insulin secretion, and promote satiety.
• GIP receptor (glucose-dependent insulinotropic polypeptide receptor, also called gastric inhibitory polypeptide receptor) — supports insulin release and contributes to metabolic regulation.
• Glucagon receptor (GCG receptor) — influences energy expenditure, fat metabolism, and other processes like increasing lipolysis.

I'm near certain it's my GLP-1 receptors that have stopped responding. The gastric emptying slowdown has ceased and the appetite regulation and satiety effects have virtually completely gone away.

Exact same experience. Glad to know I'm not alone.

I've never really experienced any side effects at any dose, so just as an experiment, I just bumping it up to 15mg a few days ago, which I'll just say worked, and some of what was occurring at 12mg calmed down a little.

That said, I don't think that is a long term solution, as it will likely happen again and I don't plan on going any higher than that, but will likely ride this out for a few more weeks before deciding my next steps.

Thanks for posting this. Glad to know I'm not alone and will check out your other thread.

 

[Waclive]

Yes imo. My appetite suppression isn’t nearly as close as what it was when I started Reta. Regardless of dosage.

That being said, weight is still dropping.

Can you clarify more on what you mean by "my appetite suppression isn't nearly as close as what it was when I started reta"? Were you on something else before trying retatrutide?

You're still losing weight no matter the dosage you're on but without appetite suppression is what you're saying?

 

[StraightCancer]

Can you clarify more on what you mean by "my appetite suppression isn't nearly as close as what it was when I started reta"? Were you on something else before trying retatrutide?

You're still losing weight no matter the dosage you're on but without appetite suppression is what you're saying?

No, Reta is the first GLP-1 I’ve ever taken.

As for losing weight, my first 3 months on Reta I dropped 70lbs then hit a plateau for over a month and experienced some low blood sugar (likely from not eating enough). I then took a 6-week break and started again a few weeks ago on 2mg. I’ve lost 12lbs since 2/1. Could be more but one of the weeks I drowned myself in alcohol for 4 days. Not an alcoholic, just an idiot.

 

[JustMakeItHappen]

You can use Hospira BAC, then add Acetic Acid to bring that pH down to about 4. Keep adding a bit of Acetic Acid and test the pH. I know Acetic Acid is technically just vinegar, but make sure that it's USP quality and 0.6%.

Hey mate, ive been using Cag for a few weeks and have only been mixing it with BAC.. only because i knew no better. Is it harmful?

 

[Itankstuff]

I can say that while I run Tesa/Ipa alongside Reta/Tirz, The scale doesn't really go down and the Ipa feels like it somewhat overrides the "suppression" effect. All that said I do seem to lose fat in my stomach area while taking those albeit not as much as I'd like. Also, when I am off those the weight seems to resume dropping fairly easily.

I've been in a similar situation. Pre christmas I was running just Tirze, losing weight at a steady rate. I added CJC/IPA in the new year and now on 8mg Reta + 5mg Tirze and the scale hasn't moved in 3 months. I do look much leaner though. I am considering stopping the CJC/IPA for 6 weeks and seeing how I go.

 

[IshimaruKenta]

Hey mate, ive been using Cag for a few weeks and have only been mixing it with BAC.. only because i knew no better. Is it harmful?

You know, given that there's not really any evidence stating that things will happen if don't do things a certain way, I honestly don't know. I'm mostly going by what the patent said and the discussion here. Since it hasn't been released, so sadly don't know much.