Reta X Cagrilintide

[zpped]

So is there a distinction between the reta not working and just not providing the appetite suppression?
With better eating habits and strength training, could reta still have the benefits of the 2 other agonist even if the appetite suppression isn't an issue?

Yes there is a distinction. Appetite and Satiety are separate functions. I get hungry and then I get full.

 

[Waclive]

Yes there is a distinction. Appetite and Satiety are separate functions. I get hungry and then I get full.

I understand they're two separate functions in the body.

I'm asking if the people saying it doesn't work is saying that based solely on the presence of food noise or if it's actually working by causing insulin sensitivity and losing body fat but not suppressing food noise.

 

[cygnus]

So is there a distinction between the reta not working and just not providing the appetite suppression?
With better eating habits and strength training, could reta still have the benefits of the 2 other agonist even if the appetite suppression isn't an issue?

Improved insulin sensitivity, nutrient partitioning, and signal for hepatic fat burn would still happen absent the "hunger" signal associated primarily with GLP-1 and thus still be working.

Cagri hitting on Amylin does make me think that Eli, Novo, or Pfizer will probably end up making a quad agonist that covers GLP-1/GIP/Glucagon/Amylin as it seems like a no-brainer given CagriSema is going to fare well and some of the vendors starting to mix reta and cagri.

CN vendors, figure out an oral MK677/orforglipron combo.

 

[Waclive]

Improved insulin sensitivity, nutrient partitioning, and signal for hepatic fat burn would still happen absent the "hunger" signal associated primarily with GLP-1 and thus still be working.

Cagri hitting on Amylin does make me think that Eli, Novo, or Pfizer will probably end up making a quad agonist that covers GLP-1/GIP/Glucagon/Amylin as it seems like a no-brainer given CagriSema is going to fare well and some of the vendors starting to mix reta and cagri.

CN vendors, figure out an oral MK677/orforglipron combo.

Thank you. That is exactly what I was looking for!

 

[Nextlevel]

I'll spout my typical "be careful of the pH level of cagri" schpeil. Don't just mix it with BAC and get the pH down to 4 ideally, or within 3.5-4.5.

How do you test the PH levels and get it higher or lower as needed? I have been losing weight with Reta 3mg (started at 1mg, then 2mg and now 3mg as I am slow rolling it) but I've heard a little cagri with reta goes a long way.

 

[CNCCurrency]

How do you test the PH levels and get it higher or lower as needed? I have been losing weight with Reta 3mg (started at 1mg, then 2mg and now 3mg as I am slow rolling it) but I've heard a little cagri with reta goes a long way.

At pH 7.4 (closer to physiological pH), cagrilintide degrades much faster, with one study showing nearly 45% degradation in 10 days compared to minimal degradation for a newer analog.

• Improved Analogs: Researchers are developing next-generation amylin analogs, like the related Compound C, which show superior stability at pH 7.4, allowing for potential co-formulation with GLP-1 drugs.

 

[thatkatmat]

Amateur hour here. I have PH strips and AA ordered and have BAC and just need clarification on what others do please.

Is it the reconstructed final vial that is tested and adjusted to get to the 4ish pH level or is it the mixture of AA/BAC that needs to be at a decent level BEFORE adding to Cagri peptide.

Thanks

I think it's the Bac/AA mixture...Anyone care to chime in?

 

[RadicalCrimson]

I think it's the Bac/AA mixture...Anyone care to chime in?

Some people have reported a 4pH reconstituted Cagri with just BAC water (pre-buffered), so IMO you should definitely test that first before adding anything.

 

[StraightCancer]

You will hear different things from different people. This is my experience I have been
experimenting with tirezepatide for almost 15 months and up to 12.5 mgs. I switched to
Reta and started at 5 mgs and had almost no appetite suppression for over a month. I moved up to 7 mgs and had a little suppression so I added .5mgs of cagri and wow
what a difference. Be careful with cagri it’s a very strong suppressant. If you over do it
you aren’t gonna like the feeling. All in all I have lost 108 pounds since I started. This
is my experience take from it what you will. I also know people that are using Reta and
tirz together .

Thank you for this.

Just an update for everyone, I hit a weight plateau after losing 70lbs in 3 months so I decided to take a break from Reta and get my metabolism back to normal.

I have only rebounded about 7lbs in the last 3-4 weeks since I have been off Reta which is healthy if anything.

That being said, I do plan on buying 10mg cagri to add to a stack or use on its own for purely appetite suppression in the future.