Ruder, At ObesityWeek, More Data and Questions About Semaglutide, Tirzepatide, and Retatrutide (2024) 331(1) JAMA 9

[keangkong]

Ruder, At ObesityWeek, More Data and Questions About Semaglutide, Tirzepatide, and Retatrutide (2024) 331(1) JAMA 9, doi.org/10.1001/jama.2023.23141.

One of the more interesting things that this article discusses is how little diet and exercise help to lose weight in comparison to the modern weight loss drugs. Here is an excerpt: "in the Semaglutide Treatment Effect for People with obesity (STEP) clinical trials, people who received semaglutide alongside an intensive lifestyle intervention lost only 1% more of their body weight than those who received the drug without intense diet, exercise, and counseling interventions."

 

[chmuse]

Ruder, At ObesityWeek, More Data and Questions About Semaglutide, Tirzepatide, and Retatrutide (2024) 331(1) JAMA 9, doi.org/10.1001/jama.2023.23141.

One of the more interesting things that this article discusses is how little diet and exercise help to lose weight in comparison to the modern weight loss drugs. Here is an excerpt: "in the Semaglutide Treatment Effect for People with obesity (STEP) clinical trials, people who received semaglutide alongside an intensive lifestyle intervention lost only 1% more of their body weight than those who received the drug without intense diet, exercise, and counseling interventions."

Can I just say that I appreciate how many of your links are easily downloadable so I can send them to my e-reader to read offline later?

Re: the article, I personally gave up calorie counting. I was leaning too far into old ED-like habits. I keep a general idea in my head on days I'm eating unhealthy crap, I order kids meals or just the smaller burger and diet soda without a side. But on days I have yogurt or cottage cheese for breakfast, bean salad for lunch, and chicken thighs for dinner, I don't even think about it. And I'm losing weight just as fast as I did obsessively weighing everything and staying under my calorie goal to the point I weighed my vegetables on a food scale.

 

[penewbie]

Diet and exercise don't work long term on the population level, we have decades of research proving it, and probably over 90% of this forum as anecdotal evidence.