Scientists boost lifespan by 70% in elderly male mice using simple drug combo

[trips]

Scientists boost lifespan by 70% in elderly male mice using simple drug combo

Scientists found that combining oxytocin with an Alk5 inhibitor revitalized extremely old male mice, boosting their lifespan and strength. Female mice showed only short-term improvements, highlighting a major sex difference in aging biology. The therapy restored youthful protein patterns in...

www.sciencedaily.com

Summary: Scientists found that combining oxytocin with an Alk5 inhibitor revitalized extremely old male mice, boosting their lifespan and strength. Female mice showed only short-term improvements, highlighting a major sex difference in aging biology. The therapy restored youthful protein patterns in blood and targeted key pathways that drive tissue decline. Because the components are already clinically accessible, this approach could move toward human testing.

thought some of you might be interested in this one. its in mice, but 70% is substantial.

 

[yrrdead]

Ok raise your hand if you are googling an Alk5 inhibitor and where to get some without reading the article......

 

[lessthanhalf]

I definitely did that when I first saw the paper a few weeks or months ago. As far as I remember there are no naturally occurring ALK5 inhibitors, that are available, specific without lots of off target effects and tested to be safe in rodents at least and preferably in humans.
Glycine, NAC, and Ergothionine are interesting though.

 

[Rezn8]

My knees are shot, my hips are run through, and my back is so arthritic I think I'll pass.

Honestly, if you offered me healthy joints in exchange for a shorter life, I might just take you up on it.

Just kidding

Sort of🤣

 

[Rolltide61]

Yes!!! I'm gonna bankrupt social security!!!!

 

[Calm Logic]

Lots of peptides seem way better for mice than us. AOD is one example (since mice are covered in beta-3 receptors, unlike humans):

Peptide Efficacy: Mice vs. Humans

Peptide/Compound	Target / Receptor	Mouse Reality	Human Reality
AOD-9604	Beta-3 Adrenergic	High target density everywhere; rapid, systemic fat loss.	Low target density in white fat; results are often negligible.
Cartalax	DNA / Epigenetic	Flips the "on" switch for collagen in factory-new tissue.	Blocked by decades of "biological rust" (glycated collagen).
TB-500	G-Actin / P2X	7x faster metabolism leads to "scarless" healing in days.	Stricter brakes (PTEN) prevent rapid cell migration for safety.
BPC-157	VEGFR2 / GH Rec.	Massive, instant up-regulation of Growth Hormone receptors.	Moderate response; limited by human vascular constraints.
ARA-290	Innate Repair (IRR)	Rapidly resets nerve pain and triggers instant repair.	Nerve repair is gated by stricter brakes to prevent misfiring.
Tesamorelin	GHRH Receptor	Extreme fat loss due to high-speed metabolic rate.	Slower, localized results due to lower receptor density.
HGH	IGF-1 / Growth Rec.	Hyper-fast tissue repair; very loose growth "brakes."	Stricter brakes limit dose-response to prevent metabolic issues.
KPV	MC1R (Immune)	Crushes inflammation instantly in tiny, low-complexity bodies.	Must battle the "noise" of a complex, aged immune system.
GHK-Cu	Copper / Gene Exp.	Rapid skin/fur regeneration and "youth" gene reset.	Struggles against decades of "biological rust" (sun/age damage).
Glutathione	Oxidative Stress	Instant detox and energy boost in high-turnover tissue.	Must clear decades of "rust" before showing systemic benefits.

 

[Habibibi]

Indeed, rodent medicine is far more advanced than human medicine, judging by all these studies.

 

[DjJoshua]

Yes!!! I'm gonna bankrupt social security!!!!

social security? let me get you my financial advisor contact info.

 

[Goonwise]

Indeed, rodent medicine is far more advanced than human medicine, judging by all these studies.

They are also much more tested so you can be sure they are much more effective as well.

 

[GimmePep]

Lots of peptides seem way better for mice than us. AOD is one example (since mice are covered in beta-3 receptors, unlike humans):

Exactly. Not everything works the same in humans as it does on mice. Lot’s of products with early studies never advance, because they don’t have the same effect on humans. I won’t take any peptides that don’t at least have some human trials showing promise.

 

[catrix]

Exactly. Not everything works the same in humans as it does on mice. Lot’s of products with early studies never advance, because they don’t have the same effect on humans. I won’t take any peptides that don’t at least have some human trials showing promise.

Look, if the price is right and it comes with a PDF from a lab I can’t pronounce, who needs human trials? 😆

 

[FRMN01]

Look, if the price is right and it comes with a PDF from a lab I can’t pronounce, who needs human trials? 😆

I identify as mice, where can I get Alk5 inhibitor. I have oxytocin already

 

[RetCurious]

Lots of peptides seem way better for mice than us. AOD is one example (since mice are covered in beta-3 receptors, unlike humans):

I've been meaning to say how much I appreciate what you bring to the table here, thank you.
I'm no fan of AI LLMs to not pull something weird out of it's butt but this seems to give pertinent information for evaluating chances of human efficacy. I assume it gives sources?
I'm really curious how your query was stated?
I'd love to see Gemini's response regarding a synthetic tetrapeptide—Lys‑Glu‑Asp‑Pro (KEDP).