Scientists boost lifespan by 70% in elderly male mice using simple drug combo

[trips]

Scientists boost lifespan by 70% in elderly male mice using simple drug combo

Scientists found that combining oxytocin with an Alk5 inhibitor revitalized extremely old male mice, boosting their lifespan and strength. Female mice showed only short-term improvements, highlighting a major sex difference in aging biology. The therapy restored youthful protein patterns in...

www.sciencedaily.com

Summary: Scientists found that combining oxytocin with an Alk5 inhibitor revitalized extremely old male mice, boosting their lifespan and strength. Female mice showed only short-term improvements, highlighting a major sex difference in aging biology. The therapy restored youthful protein patterns in blood and targeted key pathways that drive tissue decline. Because the components are already clinically accessible, this approach could move toward human testing.

thought some of you might be interested in this one. its in mice, but 70% is substantial.

 

[yrrdead]

Ok raise your hand if you are googling an Alk5 inhibitor and where to get some without reading the article......

 

[lessthanhalf]

I definitely did that when I first saw the paper a few weeks or months ago. As far as I remember there are no naturally occurring ALK5 inhibitors, that are available, specific without lots of off target effects and tested to be safe in rodents at least and preferably in humans.
Glycine, NAC, and Ergothionine are interesting though.