Selank and Semax nasal, reconstitution, storage and dosage?

[DJ _Yus]

I’m about to start my RS on Selank NA 10mg and Semax NA 10mg. And have a couple questions for more experienced researchers.

About the reconstitution for nasal applications.

• The plan is to use BAC 1ml to reconstitute
• Will pull 0.5ml and will dump on nasal spray bottle and will add 4.5ml of sterile saline.
• Will store the other half in the vial where it was reconstituted in fridge.

Is this a good idea? How long will the solution with BAC and saline stored in fridge be viable for? And how long does the one reconstituted with just BAC will last?

The idea is to start at 100mcg X day for four weeks. Rest two weeks and come back four weeks with the stored solution.

Is this a feasible and realistic and safe plan?

 

[Fostradamus]

I’m about to start my RS on Selank NA 10mg and Semax NA 10mg. And have a couple questions for more experienced researchers.

About the reconstitution for nasal applications.

• The plan is to use BAC 1ml to reconstitute
• Will pull 0.5ml and will dump on nasal spray bottle and will add 4.5ml of sterile saline.
• Will store the other half in the vial where it was reconstituted in fridge.

Is this a good idea? How long will the solution with BAC and saline stored in fridge be viable for? And how long does the one reconstituted with just BAC will last?

The idea is to start at 100mcg X day for four weeks. Rest two weeks and come back four weeks with the stored solution.

Is this a feasible and realistic and safe plan?

My method:
Recon the whole 10mg vial with 2ml of Saline.
Transfer into a Snoot bottle and add a further 8ml of Saline making 1mg/1ml.
Store in the fridge and use within 28 days.
No bac involved.
My logic is, if you use all bac to recon it will wreck your sinuses, and if you dilute it as you're suggesting it will render the bac inefective anyway. But obviously it's entirely up to you.

 

[bbbilly]

i just made a sleep spray with selank and dsip. asked in a lot of TG groups and got a ton of responses that they use this to recon and dilute and everyone seems to have had success.. i still wouldn't trust that it doesn't degrade the peptide over time but if you are going to use it within a month id hope it wouldn't do too much damage.
day 1 it seemed to work great but YMMV

 

[jamesprt]

I just mix saline solution with the powder and then put it in a spray applicator, That's what the doctor told me to do.

 

[Fostradamus]

i just made a sleep spray with selank and dsip. asked in a lot of TG groups and got a ton of responses that they use this to recon and dilute and everyone seems to have had success.. i still wouldn't trust that it doesn't degrade the peptide over time but if you are going to use it within a month id hope it wouldn't do too much damage.
day 1 it seemed to work great but YMMV

That's interesting. Tell me about your sleep spray. I have both ingredients in stock and will jump at anything to improve my sleep.

 

[lemoncrisp]

That's interesting. Tell me about your sleep spray. I have both ingredients in stock and will jump at anything to improve my sleep.

I also want to know!

 

[smartymarti]

i used 10 mg and put 2.5 ml of isotonic saline for inhalation in to vial and then 2.5 ml same solution onto bottle then add the reconstructed to the bottle making 5ml 10mg

 

[Pocket]

My method:
Recon the whole 10mg vial with 2ml of Saline.
Transfer into a Snoot bottle and add a further 8ml of Saline making 1mg/1ml.
Store in the fridge and use within 28 days.
No bac involved.

I do this as well.

 

[ambot88]

what kind of nasal sprayer thing are we using?

 

[DJ _Yus]

My idea was since my dosage will be so low to start, I wanted to try and preserve half to be used in about 45-60 days time. That why I was asking if I would keep the other half (5mg) in the vial with only BAC. But I'm guessing since BAC is only good for 28days even that will not work to preserve viability of the pep in the fridge. Correct?

 

[Chili777]

My idea was since my dosage will be so low to start, I wanted to try and preserve half to be used in about 45-60 days time. That why I was asking if I would keep the other half (5mg) in the vial with only BAC. But I'm guessing since BAC is only good for 28days even that will not work to preserve viability of the pep in the fridge. Correct?

I would plan to make as much as you need to last 30 days, rather than add BAC. It will eventually cause drying and irritation. The BAC may last longer than that, but it's really not necessary. I've used sterile saline and kept it refrigerated and it has been crystal clear for the cycle.

You also need a washout period because the BDNF receptors can get overloaded after 30 days of continuous upregulation. I typically run 30 days on and at least 14 days off, minimum.

 

[Clavicular's Hammer]

Is this a proven method?

Very interested in trying these and not taking another needle

 

[bay_area_schizo]

I would plan to make as much as you need to last 30 days, rather than add BAC. It will eventually cause drying and irritation. The BAC may last longer than that, but it's really not necessary. I've used sterile saline and kept it refrigerated and it has been crystal clear for the cycle.

You also need a washout period because the BDNF receptors can get overloaded after 30 days of continuous upregulation. I typically run 30 days on and at least 14 days off, minimum.

thank you for the on off cycle information. in getting ready to try this whole IN business. question: how long before bed are you spraying? I'm worried about spraying and then laying down to sleep and getting a sinus infection.

 

[rmhla]

I’m about to start my RS on Selank NA 10mg and Semax NA 10mg. And have a couple questions for more experienced researchers.

About the reconstitution for nasal applications.

• The plan is to use BAC 1ml to reconstitute
• Will pull 0.5ml and will dump on nasal spray bottle and will add 4.5ml of sterile saline.
• Will store the other half in the vial where it was reconstituted in fridge.

Is this a good idea? How long will the solution with BAC and saline stored in fridge be viable for? And how long does the one reconstituted with just BAC will last?

The idea is to start at 100mcg X day for four weeks. Rest two weeks and come back four weeks with the stored solution.

Is this a feasible and realistic and safe plan?

I find the nasal wasnt as effective as the injection version however it works somewhat.

 

[Chili777]

thank you for the on off cycle information. in getting ready to try this whole IN business. question: how long before bed are you spraying? I'm worried about spraying and then laying down to sleep and getting a sinus infection.

If you're talking about Selank prior to bed, I find IN too close to bedtime keeps me up and I don't sleep as well. Selank via SQ works well about 2 hours before bed. I think that's crazy, but that's how it seems to work for this RS. Everyone is different. I don't use any Semax-based pep after 2 pm. The residual effects still bother me as I'm a good responder.

I did get a sinus infection about 8 months ago after 3 months of IN cycling Epitalon, then Semax, and then Selank. I was being a peptide hog, so I have since slowed it down. I also didn't filter early on, so I'm sure that didn't help my sinuses. The sinus mucosa has robust defenses but I now give it all the help I can by filtering.

 

[Chili777]

Is this a proven method?

Very interested in trying these and not taking another needle

I and a lot of other RSs find it very effective. There are several long threads here regarding IN peptide candidates, RS experiences with them, and how to properly reconstitute for IN.

 

[Clavicular's Hammer]

I and a lot of other RSs find it very effective. There are several long threads here regarding IN peptide candidates, RS experiences with them, and how to properly reconstitute for IN.

Thank you very much for the confirmation

K these were all things I had hoped to try but just couldn’t justify adding more injections on top of the ones I am doing for weight loss and my other physical health

 

[DJ _Yus]

If you're talking about Selank prior to bed, I find IN too close to bedtime keeps me up and I don't sleep as well. Selank via SQ works well about 2 hours before bed. I think that's crazy, but that's how it seems to work for this RS. Everyone is different. I don't use any Semax-based pep after 2 pm. The residual effects still bother me as I'm a good responder.

I did get a sinus infection about 8 months ago after 3 months of IN cycling Epitalon, then Semax, and then Selank. I was being a peptide hog, so I have since slowed it down. I also didn't filter early on, so I'm sure that didn't help my sinuses. The sinus mucosa has robust defenses but I now give it all the help I can by filtering.

Do you filter with regular 13mm PES filter? Even when reconstituted with saline?
Wouldn't the filter remove the saline and by consequence trap some of the pep in the membrane?

 

[Chili777]

Do you filter with regular 13mm PES filter? Even when reconstituted with saline?
Wouldn't the filter remove the saline and by consequence trap some of the pep in the membrane?

I personally use 4mm filters for 3 mL or less. I reconstitute with 1 mL sterile saline, filter the peptide into the spray bottle, and then add the remaining saline.

Removing the mineral content with syringe filters isn't an issue. They aren't designed to remove mineral content from solutions like sterile saline; they primarily filter out particulates and impurities which are larger.

For mineral removal, other filtration methods like reverse osmosis would be more appropriate. Likewise, any peptide we are likely to use is much smaller than the .22u pore size of a PES filter.

 

[n8crow]

If you want one spray to equal a typical dose, e.g. 250 µg then dissolve 10mg in 4mL saline solution.

I usually reconstitute two 10mg vials with 2mL saline each, then filter into a nasal spray bottle and add 4mL more saline and mix.

Semax and Selank are highly effective intranasally. In fact, this is the primary and most studied route of administration for these peptides. Unlike many other peptides that require injection to be effective, their low molecular weight and a specific structure that allows them to bypass the blood-brain barrier effectively when administered through the nose.

 

[bay_area_schizo]

If you're talking about Selank prior to bed, I find IN too close to bedtime keeps me up and I don't sleep as well. Selank via SQ works well about 2 hours before bed. I think that's crazy, but that's how it seems to work for this RS. Everyone is different. I don't use any Semax-based pep after 2 pm. The residual effects still bother me as I'm a good responder.

I did get a sinus infection about 8 months ago after 3 months of IN cycling Epitalon, then Semax, and then Selank. I was being a peptide hog, so I have since slowed it down. I also didn't filter early on, so I'm sure that didn't help my sinuses. The sinus mucosa has robust defenses but I now give it all the help I can by filtering.

thanks for getting back to me...very good info 💯

 

[Tadpole1]

Can semax and selank be ok adding to a stack of
Reta
Motc
Nads
Glow

Thanks🙂