Semaglutide raw powder not stable?

[Foobar1980]

Hi all,

I hope someone can help me with this
I used freezedried Sema 10mg vials for quite some time and dilluted it with NaCL 0.9%. Always kept it in the fridge and solution was okay for > 2 months.

Now I bought raw semaglutide powder frome same distributor. Dilluted it with NaCl and added 1% of pure benzylalcohol (by myself) and than filtered it with .22 micronfilter and made my 10mg in 2 ml vial.

Tried it multiple times, but always after 2 or 3 weeks the solution gets flakey, and strings will form in the liquid. After a little bit of shaking, the flakes and strings go away, but will form again after 30 min. What is going wrong? Why is the solution not stable? Do you have any tips for this? Is is degrading faster?

Could it be the because of the pH of the filling agent? Should I try ‘normal’ 0.9 NaCL? Or BAC water of the shelf?

Hope someone can help me with this. Thanks in advance.
Best regards!

 

[Calm Logic]

What is going wrong?

I assume it's entirely because you are using raw, not the freeze-dried (lyophilized) you were using successfully before. I haven't even heard of using raw peptides except for topical use.

In other words, throw that shit away

For example:

It's actually very easy to buy raw tirz in bulk. it's just not feasible for most people to do anything with it.

The powder that is in the vials has been finished. They take the raws, dissolve it, mix with stabilizers and fillers, filter it, put it in vials as a liquid, lyophilize it again, and seal the vials.

potential issues with stability, sterility, dosage accuracy, and efficacy