Split Dose with Zep Vials

[StephKruze]

I've seen some discussion about taking a half dose twice a week instead of the full dose once a week. (or other variations) The pros and cons aren't really clear, other than potentially staying within a more consistent level and not having such a difference in the high and lows.

I'm going from 5mg to 7.5 mg of Zepbound (single dose vials) in about a week, and I've been thinking about splitting the dose in half and taking it every 4 days. Just wonder who else has done this and how it worked? Is it really a significant concern doing this as long as you use the open vial within a few days and keep it sanitary?

 

[GLP1Pharmacist]

If done with decent technique most suggest vials are good for 30 days in refrigerator.

 

[Calm Logic]

If done with decent technique most suggest vials are good for 30 days in refrigerator.

...at least. Some members feel safe using a vial for up to 90 days, or depending on the number of jabs.

 

[mlke6]

If done with decent technique most suggest vials are good for 30 days in refrigerator.

I use mine until they are finished. I do log when I reconstitute but thats about it.

 

[ididntdoit]

These are Zep vials, correct? Supposedly they have no preservatives. I think this falls into the category of "what level of risk-taker are you". Personally, I would be perfectly fine using them as you stated. Other people, not so much.

 

[TooBigtoFail]

To split dosage effectively, try this site https://glp1plotter.com/.
Figure out the peak residual for a 7 days cycle, then find the matching peak for 3/4/5 days.
Search the forum and scientific studies on Bac for pro/cons on longevity, and pep degradation over long time periods. Keep the vial stopper clean using isopropyl alcohol.

You can search for "zepbound excipient composition" or search the NIH's DailyMed site for vial exact composition. Lilly single use pen/vials do not use preservatives and have a short life. Multi use use two different preservatives. Their literature has expiry dates, use date, etc.

I get grey vials with high dosage and commonly reuse for 6-8 weeks by adding Bac with benzyl alcohol and keeping everything very clean.

 

[Calm Logic]

I missed the single-vial part. Marijuana gummy striked again.

Since it is preservative-free, I have no idea what I would do if wanting to split. I would be too lazy to want to bother with buying and adding benzyl alcohol, for a short-term situation. At the very minimum, you would aim for perfect sterile technique, including wiping the vial with 70 percent rubbing alcohol before and after.

But I do believe more is better at least until 10 mg of tirz, so I would just take the whole 7.5 mg at once:

 

[Calm Logic]

According to Google Gemini:

If you take 3.75 mg every 4 days, your weekly dose would be 6.5625 mg.