SS-31/Mots-C/NAD+/5-Amino

Ambitious to be sure. My only question would be the NAD+ daily vs a M-W-F routine. Just don’t think I’ve seen any protocols recommending that.

Good luck!
 
latviantower said:
Ambitious to be sure. My only question would be the NAD+ daily vs a M-W-F routine. Just don’t think I’ve seen any protocols recommending that.

Good luck!
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Honestly it just math'd out like that to deplete all my stock the same week. I ran the posted protocol last year and decided to up the doses and length. First time using 5-Amino.
 
Such1943 said:
28 weeks
SS-31 5mg daily
NAD+ 100mg daily
Mots-C 5mg M/W/F
5-Amino-1MQ 40mg daily (7 weeks)
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You and I are on a similar journey, except I didn't start everything at once.
  • I started with NAD+ at 25 mg and only recently increased it to 50 mg.
  • Then I added SS-31 at 5 mg daily and ran two cycles.
  • After that, I added MOTS-c at 5 mg for one cycle, followed by 5-Amino-1MQ at 50 mg.
  • Most recently, I added SLU-PP-332 at 1 mg.
I'm no longer on SS-31 for now, although I may run another cycle in the future. I also plan on increasing MOTS-c to 10 mg soon. Why? Because I tolerate 5 mg without any side effects, and the longevity protocols generally support higher dosing.

What made the biggest difference? SS-31, without question. MOTS-c would be second. I never really feel anything positive from NAD+ on its own. As for 5-Amino-1MQ, I still don't notice anything at 50 mg. Should I increase it to 100 mg? I did a one-hour cardio session today after injecting 50 mg, and my heart rate stayed around 56~67bpm for most of the workout.

SLU-PP-332 is still too early to judge since I've only been on it for a few days, but so far I haven't noticed anything from it either.
 
miameow said:
You and I are on a similar journey, except I didn't start everything at once.
  • I started with NAD+ at 25 mg and only recently increased it to 50 mg.
  • Then I added SS-31 at 5 mg daily and ran two cycles.
  • After that, I added MOTS-c at 5 mg for one cycle, followed by 5-Amino-1MQ at 50 mg.
  • Most recently, I added SLU-PP-332 at 1 mg.
I'm no longer on SS-31 for now, although I may run another cycle in the future. I also plan on increasing MOTS-c to 10 mg soon. Why? Because I tolerate 5 mg without any side effects, and the longevity protocols generally support higher dosing.

What made the biggest difference? SS-31, without question. MOTS-c would be second. I never really feel anything positive from NAD+ on its own. As for 5-Amino-1MQ, I still don't notice anything at 50 mg. Should I increase it to 100 mg? I did a one-hour cardio session today after injecting 50 mg, and my heart rate stayed around 56~67bpm for most of the workout.

SLU-PP-332 is still too early to judge since I've only been on it for a few days, but so far I haven't noticed anything from it either.
Click to expand...
I followed that structure last year. I read somewhere that after the "repair", it might be better to run them together. I did not notice much from Mots-C last time. Cleared my head and gave me clean energy at the end of the day. Overall I felt the stack was worth running yearly.
 
FartfulCodger said:
Don't forget that it's all Hospira-based.
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Nope.

Sterile water for injection for the 5-amino-1-mq is enough since it's a quaternary ammonium. An antibacterial more potent than BA. My favorite dope.

Ss-31 and MOTS-C are doing well with NaCl 0.9% without BA. It prevents ISRs. At 5mg per day, the vials will last 8 and 10 days. This is short enough to do it without BA. But you can opt for saline BA if you have doubts about your aseptic techniques.

I don't notice any significant difference between 5 and 10 mg of 5am1q. I certainly won't go up to 40 mg for two reasons. First, that's above the plateau dose in the mouse studies. Second, it's a possible mutagen, and until we know more, I'll stick with the first dose that works for me (metabolic syndrome).

I don't use NAD+ in shots. I'm not addicted to that kind of boost. And oral B3, NR, and NMN will have the same effect over time. It's just a matter of kinetics, not dynamics. There isn't really a bioavailability issue. Sometimes one form is easier to absorb than another, apparently depending on the gut microbiota.
SubQ/IM NAD+ is just marketing: in rush? Pay more.

MOTSc was discovered in 2015; I doubt we have much data on its effects on longevity. It's a good supplement when it doesn't cause ISR.

SS-31 had a lasting effect on me after 6 weeks. It's worth continuing, even at this price.
 
SS31 is great, we just got our first kit of 100mg. Waiting on the 500mg kit to arrive with 5AM as well.

The SS31 is very promising. It has improved my cardio greatly alongside CoQ10.

I'm planning to run a higher dose alongside carnitine, PQQ, CoQ10, and ALCAR to see what it can really do for my heart.

latviantower said:
My only question would be the NAD+ daily vs a M-W-F routine. Just don’t think I’ve seen any protocols recommending that.
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Protocols are just something that someone came up with. There's no evidence to suggest that it ought to be taken at one schedule versus another.
 
I am in week four of this protocol. The only thing I am going to change so far is add the 5 Amino to the last couple weeks. I start the MOTS-c tomorrow
I will be following your progress to see if I want to change anything for when I do it again next year.
1782751229181.webp
 
AcadiaPeptides said:
I am in week four of this protocol. The only thing I am going to change so far is add the 5 Amino to the last couple weeks. I start the MOTS-c tomorrow
I will be following your progress to see if I want to change anything for when I do it again next year.
View attachment 29141
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Last summer I felt the most from the SS-31, it really cleared the brain fog. NAD+ was good clean energy, I stopped drinking coffee while on cycle. I wanted to combat the Reta fatigue. This round I just went full bore with the highest concentration vials and bumped the doses and length to finish all kits the same week. Nothing overly complicated, just rippen.
 
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