Split vs Single dose- how many mg?

[articfox]

Okay just to open a can of worms, who is splitting their doses and who is going singular ? How many mg’s are you up to ?

I have previously split my dose and feel that there isn't as many highs and lows, but I am on the singular route for convenience.

Im up to 4mg and looking at the clinical trials there isnt much difference from 6mg just more side effects.

Back to you ?

 

[woundcarping]

I 2x split, 7mg/weekly. I split the heck out of my bridge from Tirz to Reta in 17 days before two 4mg doses, and settling to 3.5mg.

Almost no sides, cold sensitivity is a thing, hasn’t been objectionable. Highest peak was 9.7mg. The 4mg doses 3 days apart flattened my appetite a bit too deep, hence the 3.5mg.

 

[articfox]

I 2x split, 7mg/weekly. I split the heck out of my bridge from Tirz to Reta in 17 days before two 4mg doses, and settling to 3.5mg.

Almost no sides, cold sensitivity is a thing, hasn’t been objectionable. Highest peak was 9.7mg. The 4mg doses 3 days apart flattened my appetite a bit too deep, hence the 3.5mg.

Ive never taken triz, how does it compare to reta. Do you feel anything on it other than less hunger ?

 

[woundcarping]

For me it suppressed hunger and food noise. I didn’t have a bad time with it, but Reta’s data matched my goals better, it seemed.

 

[redbullwings]

I’ve been messing about to get a feel of what works better for me. Been on reta since Sept’ 2025. From the start I was splitting my doses of reta and have continued since.

Now I’m on 6mg of Reta & splitting has worked pretty well. Less food noise, suppressed appetite. Steadily losing fat.

Then recently, I saw discussion around pinning once weekly & its benefits, one of it being less wrecked sleep. Did some research so I switched to that for three weeks and I could tell the difference. More hunger, more food noise and some cravings. Didn’t gain any weight though.

No difference with wrecked sleep but then again I’m a newly qualified nurse doing a mix of nights and dayshifts.

But I’m switching back to splitting 6mg a week.

Not end of the world. Just wanted to mess around and see the results. But I learnt the lesson of “what works well for you, why change?”

 

[Fat2Fit26]

When people say they’re splitting reta on 6mg I’m guessing that means two doses of 3mg a week? And not two 6mg doses.

With it having a half life of 6 days seems potentially excessive to split the dose no? Maximum concentration is said to be 12-72 hours so you’re re-dosing then at max concentration.

Maybe re-dosing on day 5 or 6 may make more sense if feeling a lot of food noise, hunger and cravings towards day 6/7. Although understand that’s harder to keep track with the day moving each week.

 

[randompersonrandom]

I don't split my tirz, but I started splitting my Survo by accident. I got my day mixed up, accidentally did a second pin four days after the first, and realized I'd made the mistake when I had a very slight amount of nausea, no interest in food for three days after, and dropped a little weight when I hadn't been dropping much lately. Then went "Oh. Huh. Let's try that again."

 

[monsterultra23]

I just do one every 6 days. Going from TIRZ to reta has gone alright. Slight increase in hunger levels, but only leading up to meal times anyway so it's easily manageable. Was on 10mg tired and started reta at 2.5.

 

[redbullwings]

When people say they’re splitting reta on 6mg I’m guessing that means two doses of 3mg a week? And not two 6mg doses.

With it having a half life of 6 days seems potentially excessive to split the dose no? Maximum concentration is said to be 12-72 hours so you’re re-dosing then at max concentration.

Maybe re-dosing on day 5 or 6 may make more sense if feeling a lot of food noise, hunger and cravings towards day 6/7. Although understand that’s harder to keep track with the day moving each week.

Yeah 3mg twice a week, I hope my post isn’t confusing and reading as though it’s two 6mg doses lol. I don’t want to ascend into heaven anytime soon

 

[yrrdead]

I split my Reta from the jump. Currently trying to adjust to a weekly maintenance dose. Which I figure will be between 2-3mg/week. Will go to 2.5mg/5days next pin.

 

[morepepinmystep]

I started Reta almost a month ago. I started at 1mg once a week. The studies show it has a half life of 6 days but I noticed the food noise came back on day 4. So after experiencing this I titrated up by adding another 1mg split the next week. I pin Sunday and Thursday evenings and so far has worked well. Currently at 3mgs split(1.5mg/1.5mg). If I wanted to be exact I should pin every 4 days but I find it easier to have set days. This was my experience.

 

[woundcarping]

With it having a half life of 6 days seems potentially excessive to split the dose no? Maximum concentration is said to be 12-72 hours so you’re re-dosing then at max concentration.

That’s not how the math works.

 

[Purplepansy]

Okay just to open a can of worms, who is splitting their doses and who is going singular ? How many mg’s are you up to ?

I have previously split my dose and feel that there isn't as many highs and lows, but I am on the singular route for convenience.

Im up to 4mg and looking at the clinical trials there isnt much difference from 6mg just more side effects.

Back to you ?

I have done both. I used tirz for 5 months and never lost a pound. Slowing adding Reta and eliminating Tirz. I started with split dosing and was as high as 6mg twice a week for a total of 12mg. I had a hard time eating at that dose and was not getting in enough protein. The only side effects I had were being cold all the time and a runny nose. I decided to back off and try lowering my dose to once a week every 6 days. I skipped two weeks and then started with 6mg once every 6 days. I moved up 1 mg every 4 weeks until I landed at 8mg. I have more side effects on once a week than splitting my dose. I had a hard time with the constipation and the terrible itching in the calf area of my legs. This week I am back to split dosing. I have slowly lost 62 pounds over 16 months. I still have about 20 pounds to lose. It has been a slower process for me but I am grateful to finally find something that works. From a short obese old lady with Hashimotos trying to lose the extra baby weight from 40 years ago to just an overweight old lady with Hashimotos.

 

[BioDad]

Okay just to open a can of worms, who is splitting their doses and who is going singular ? How many mg’s are you up to ?

I have previously split my dose and feel that there isn't as many highs and lows, but I am on the singular route for convenience.

Im up to 4mg and looking at the clinical trials there isnt much difference from 6mg just more side effects.

Back to you ?

I split it at first thinking that was superior and researched the heck out of it, even contacting lead researchers on major papers on retatrutide. I was convinced it was a superior way and the once-a-week dosing in research was more out of convenience than it was pharmacodynamics/kinetics.

I've since changed my tune and now do a once weekly schedule. Not only is that only what has been researched, but - I'd have to dig up my notes on it as it was a couple of months ago - what ended up convincing me was the steady decline throughout the week might actually result in it working a little better from a receptor point of view. If I recall, there was a paper on Semaglutide that tipped my scales on that but again, I'd have to dig it up.

 

[Not_Your_Dad]

I’m rolling 4 mg every 84 hours.

Nonexistent side effects, coming from getting my ass kicked by 12.5 mg Tirz.

I get a little hungry around hour 72 but nothing I can’t manage.

 

[bogardbilla]

I'm on 7mg every 6 or 7 days, depends on my life schedule. I've done the split dosing thing only in the first two weeks, so I can't really compare the two.

 

[Fat2Fit26]

That’s not how the math works.

Hey Woundcarping. I’m here to learn. It wasn’t a statement of fact, just how I currently understand it. Would be great if you could clear up the math for me so I have a better understanding.

Thanks!

 

[OregonSunshine]

I split it at first thinking that was superior and researched the heck out of it, even contacting lead researchers on major papers on retatrutide. I was convinced it was a superior way and the once-a-week dosing in research was more out of convenience than it was pharmacodynamics/kinetics.

I've since changed my tune and now do a once weekly schedule. Not only is that only what has been researched, but - I'd have to dig up my notes on it as it was a couple of months ago - what ended up convincing me was the steady decline throughout the week might actually result in it working a little better from a receptor point of view. If I recall, there was a paper on Semaglutide that tipped my scales on that but again, I'd have to dig it up.

I think I've read about how researchers have found that the receptors get desensitized over time so that makes sense. It also explains why the studies have shown minimal continued weight loss after the initial 16-18 months (even for people who had more to lose). There something to be said about scaling up dosing and going as hard as is manageable to get as much extra weight off as possible in those 16-18 months.

 

[Dogmandu]

I went from pinning every 3 days to once a week about 2 months ago. Very early on, Reta caused me some sleep issues, so I was worried about insomnia with the bigger spike from once-a-week shot. But so far, it's been fine. Glad I went to weekly. I would not go back to split because weekly is easier and the weight loss is happening at a nice pace.

Split dosing may still be worth considering if you are sensitive to side effects.

 

[morepepinmystep]

Hey Woundcarping. I’m here to learn. It wasn’t a statement of fact, just how I currently understand it. Would be great if you could clear up the math for me so I have a better understanding.

Thanks!

I personally split dosing because I notice a drop off on day four, not day 6 like the clinical trials state. Splitting the dose seems to alleviate side affects for me and keeps the levels in my system more consistent, think less highs and lows. Here is an image i referred to when deciding to switch. If one a week works for you, great! If you notice drop off, there are more options out there.

 

[Not_Your_Dad]

For anyone who may be interested, scope this:



From our friends at GLP-1 Plotter. The top graph is 8.75 mg Tirz administered every 84 hours; the bottom is 17.5 mg Tirz every 7 days. The peaks on the split dosing aren't quite as high, but the valleys are definitely not as low. My Mrs. does this and it seems to keep a more consistent level of Tirz in the body and lessen the once-weekly post-injection side effect hell she has.

 

[Fat2Fit26]

I personally split dosing because I notice a drop off on day four, not day 6 like the clinical trials state. Splitting the dose seems to alleviate side affects for me and keeps the levels in my system more consistent, think less highs and lows. Here is an image i referred to when deciding to switch. If one a week works for you, great! If you notice drop off, there are more options out there.

This is super interesting Morepep! Thanks for sharing those ratios.

I do notice a considerable dip between days 5-7 but have just battled through it feeling very hungry so far. I had simply read it was a waste and pointless dosing my more than once a week. Going to do some maths for day 5 re-pin.

Cheers!

 

[morepepinmystep]

This is super interesting Morepep! Thanks for sharing those ratios.

I do notice a considerable dip between days 5-7 but have just battled through it feeling very hungry so far. I had simply read it was a waste and pointless dosing my more than once a week. Going to do some maths for day 5 re-pin.

Cheers!

I do just set days, Sunday and Thursday nights. It works better for me to know my schedule. I guess if I wanted to be super consistent I would just dose every four days. There is just so much info and people doing one way or another. Do what works best for you!

 

[lessthanhalf]

In my experience side effects definitely relate to peak levels, happening about 24 hours after a dose - which is how long it takes for peak blood levels after a dose, more or less .
With Semaglutide the effect on nausea was extremely unsubtle, the only way I could ever get above 0.5mg/week was dosing 0.22mg per 2 days and increases as small as 0.02mg per dose were enough to make nausea worse, which seems ridiculous but the effect was completely repeatable. Changed to tirzepatide 6 months ago , stayed on 2nd daily doses out of habit mostly. Way less side effects at 4.5mg per 2 days = 15.75mg/week.
With retatrutide I am taking 1.4mg every 2 days, on top of tirzepatide, even very small increases in dose like 0.2mg are enough to cause skin sensory symptoms, so I cannot go higher in dose.
I am in an unusual situation only starting them a year after losing 90% of the weight, and aiming for the highest dose I can tolerate without too many unpleasant side effects to maximise hunger control to make it easier to maintain a 54% weight loss.
Split dosing is super useful to help control side effects if you do not want to reduce doses, and is useful for adjusting doses up and down more quickly, as each individual smaller dose will wear off faster than a single larger dose if it is causing problems. And useful if you are trying to find an exact maximum dose that you can tolerate which is not a common issue.

 

[Fat2Fit26]

In my experience side effects definitely relate to peak levels, happening about 24 hours after a dose - which is how long it takes for peak blood levels after a dose, more or less .
With Semaglutide the effect on nausea was extremely unsubtle, the only way I could ever get above 0.5mg/week was dosing 0.22mg per 2 days and increases as small as 0.02mg per dose were enough to make nausea worse, which seems ridiculous but the effect was completely repeatable. Changed to tirzepatide 6 months ago , stayed on 2nd daily doses out of habit mostly. Way less side effects at 4.5mg per 2 days = 15.75mg/week.
With retatrutide I am taking 1.4mg every 2 days, on top of tirzepatide, even very small increases in dose like 0.2mg are enough to cause skin sensory symptoms, so I cannot go higher in dose.
I am in an unusual situation only starting them a year after losing 90% of the weight, and aiming for the highest dose I can tolerate without too many unpleasant side effects to maximise hunger control to make it easier to maintain a 54% weight loss.
Split dosing is super useful to help control side effects if you do not want to reduce doses, and is useful for adjusting doses up and down more quickly, as each individual smaller dose will wear off faster than a single larger dose if it is causing problems. And useful if you are trying to find an exact maximum dose that you can tolerate which is not a common issue.

I noticed skin sensitivity (allodynia) with Reta when I got to 3.5mg. On 4mg now and just rode it out. It has dropped significantly. It’s still there a little but over about 2-3 weeks it’s dropped dramatically.

That’s an interesting report though, and a great point about being able to adjust doses more quickly. Definitely think I’m going to consider a split dose going forward now. Thanks

 

[Fat2Fit26]

For anyone who may be interested, scope this:

View attachment 15738

From our friends at GLP-1 Plotter. The top graph is 8.75 mg Tirz administered every 84 hours; the bottom is 17.5 mg Tirz every 7 days. The peaks on the split dosing aren't quite as high, but the valleys are definitely not as low. My Mrs. does this and it seems to keep a more consistent level of Tirz in the body and lessen the once-weekly post-injection side effect hell she has.

I imagine if the peaks aren’t as high you can still manage to keep protein intake up easier, and with lower troughs the food noise and hunger stays better suppressed. This is great info. Thanks

 

[JuneBug1956]

I love the Glip plotter that not your dad posted and used it for my first year on Glips. I split Tirz twice a week getting 10 mg x 2 for up to 20 mg weekly. I decided to back down and add some Sema 2-3 days after the weekly Tirz. That really helped my appetite supression. Eventually added small amount of Cagri which gave me a lot of energy. I am in maintenance and still do all 3 just stretching my days to every 8-9 days. SW 250, CW 140. Have been at it 2.5 years . I love hearing about everyone’s journey and am in awe of how different we all are.

 

[lessthanhalf]

The skin side effects seem to be pretty variable. Lots of people have said they had it but it went away after a while. I had it once or twice when I was pushing the dose of tirzepatide up, which went away. I assume I am only getting it now due to the combination of reta and tiz, I do get it a bit on my normal dose but not enough to be genuinely annoying or uncomfortable, but now even bumping reta up a tiny bit has caused it to be annoying while trying to sleep.
Split doses do make adjustments quicker but you still need to be careful as each peak after a new dose that is the same will still be higher for 4 or so doses until you get to a steady state, so checking what blood level you are at with glp plotter is a good idea as blood levels are totally not intuitive, as glp drugs are so different to virtually every other drug used in terms of slow absorption and super long half life so normal logic or guessing about what it might be doing is not usually helpful.

 

[Not_Your_Dad]

I think GLP plotter is an excellent tool to have on hand - I'm not interested in telling anyone what they should or shouldn't be doing. I like to report my own experiences and hear about all of yours as well. I think we should use all the tools at our disposal to create as much data as possible to help inform the decisions we make, and GLP plotter fits in well with that.

 

[wildcat0367]

I have been on Tirz for over a year at 7.5 mg at 2 X a week. This almost eliminated any sides for me and evened out food noise throughout the week. Blood levels stay more even and you can run a higher dose this way minimizing sides if needed. I am at goal now and maintaining well. Insulin and blood sugar control at this dose is great. Dropping to 5 mg soon.