Switching from BAC water to BAC Saline (with reasoning and general impressions)

Camlbacker

GLP-1 Apprentice
Member Since
Nov 19, 2025
Posts
105
Likes Received
333
Location
Michigan
United-States
As anyone who has been conducting research in this space in the last several months knows, the Gold Standard Hospira Bac Water has gone up substantially in price and become harder to get. When Amazon pulled all the BAC off their site and demand for Hospira made it pretty scarce for a few weeks and ultimately more costly, I decided to start researching alternatives. Like most people living in 2026, I don't particularly appreciate being price gouged; beyond that there were a few weeks there where people weren't sure where to get a good supply of BAC water to continue their research. This would not do for me. I had gotten a few bottles of Lambda just to see if there was any practical difference between it and the Hospira. For me, there isn't one that I can discern so far into my third bottle, other than that Lambda uses glass vials (quite preferable in my view) and that the bottles are tall and narrow and easy to knock over, which obviously isn't ideal. So once they got their crap together with their credit card processing, I ordered a bunch more Lambda, just in case the BAC water shit really hit the fan.

Like a lot of you, I find some peps to be spicy. For me, Mots-C is the worst of the worst in this regard; but also for me it's some of the most valuable research I do on an ongoing basis, so it behooves me to find a way to minimize ISRs. Higher dilution ratios do improve things, however even a 10mg/ml dilution using 4ml for a 40mg vial doesn't remove ISRs entirely with regular BAC. I could go up to 8, but under the current circumstances I would prefer to conserve BAC. I've been hearing a lot about BAC Saline in recent weeks and how and why it seems to improve ISRs, and it's definitely cheaper: I just bought some for less than $7 a bottle, and you can get a case of 24 for around $100.

Today began my research using BAC Saline for reconstituting Mots-C and Korean Glutathione (the pink Glutaone for the initiated). I reconned the Mots at 2ml per 40mg. It reconned crystal clear and dissolved completely in a couple of minutes. For the Gluta, I started with 3ml for a 1200mg vial; when that took awhile to dissolve, I added 1ml and that took care of the issue. Dissolved crystal clear. I don't have much if any issue with Gluta straight into the ventral glute, and if anything, it's even cleaner using BAC Saline. 1st dose was .5ml for a total of 150mg. Uneventful. The Mots-C is a bit more nuanced. The ISR is pretty minor so far (less than it would be with regular BAC, I think), and I will have a better sense of that tomorrow morning and over the next few days as I continue my work. I will recon the next vial with 4ml to see if that further reduces the ISR or eliminates it entirely.

If there is an interest in the community for this particular subject matter, I will be glad to update with any new and relevant information. If you have any questions about anything, feel free to ask. My understanding is that Reta and Tesa/Ipa are not compatible with BAC Saline, so at least for now, I'm not going to try those. I will be attempting with SS-31, Klow and its individual components, NAD, and probably a couple of others once I have adequate stock to sacrifice a vial to the research gods if it comes to that. As always, please keep the discourse non-violent, and thanks so much for reading.
 
You know, I'd love to see more robust discussions on this. My mom does klow, epitalon, and tirz. She'll never use reta because she'll never need it. She's got five bottles of bac water and that'll last her at least a year, but the price just keeps going up and up. I have two cases, and she'll never run out on my watch, but I was thinking about how I don't actually know if those three (six of you count the individual components of klow) would be just fine to use with saline.
 
Last edited:
YES! Thanks for this detailed info! I got myself into a righteous tizzy earlier today related to reconstitution, pH and spicy shots, so this is exactly the kind of info I’m looking for (plus I have some NaCl BAC on order for the NAD+/SS-31/MOTS-C protocol). Watching this thread.
 
As anyone who has been conducting research in this space in the last several months knows, the Gold Standard Hospira Bac Water has gone up substantially in price and become harder to get. When Amazon pulled all the BAC off their site and demand for Hospira made it pretty scarce for a few weeks and ultimately more costly, I decided to start researching alternatives. Like most people living in 2026, I don't particularly appreciate being price gouged; beyond that there were a few weeks there where people weren't sure where to get a good supply of BAC water to continue their research. This would not do for me. I had gotten a few bottles of Lambda just to see if there was any practical difference between it and the Hospira. For me, there isn't one that I can discern so far into my third bottle, other than that Lambda uses glass vials (quite preferable in my view) and that the bottles are tall and narrow and easy to knock over, which obviously isn't ideal. So once they got their crap together with their credit card processing, I ordered a bunch more Lambda, just in case the BAC water shit really hit the fan.

Like a lot of you, I find some peps to be spicy. For me, Mots-C is the worst of the worst in this regard; but also for me it's some of the most valuable research I do on an ongoing basis, so it behooves me to find a way to minimize ISRs. Higher dilution ratios do improve things, however even a 10mg/ml dilution using 4ml for a 40mg vial doesn't remove ISRs entirely with regular BAC. I could go up to 8, but under the current circumstances I would prefer to conserve BAC. I've been hearing a lot about BAC Saline in recent weeks and how and why it seems to improve ISRs, and it's definitely cheaper: I just bought some for less than $7 a bottle, and you can get a case of 24 for around $100.

Today began my research using BAC Saline for reconstituting Mots-C and Korean Glutathione (the pink Glutaone for the initiated). I reconned the Mots at 2ml per 40mg. It reconned crystal clear and dissolved completely in a couple of minutes. For the Gluta, I started with 3ml for a 1200mg vial; when that took awhile to dissolve, I added 1ml and that took care of the issue. Dissolved crystal clear. I don't have much if any issue with Gluta straight into the ventral glute, and if anything, it's even cleaner using BAC Saline. 1st dose was .5ml for a total of 150mg. Uneventful. The Mots-C is a bit more nuanced. The ISR is pretty minor so far (less than it would be with regular BAC, I think), and I will have a better sense of that tomorrow morning and over the next few days as I continue my work. I will recon the next vial with 4ml to see if that further reduces the ISR or eliminates it entirely.

If there is an interest in the community for this particular subject matter, I will be glad to update with any new and relevant information. If you have any questions about anything, feel free to ask. My understanding is that Reta and Tesa/Ipa are not compatible with BAC Saline, so at least for now, I'm not going to try those. I will be attempting with SS-31, Klow and its individual components, NAD, and probably a couple of others once I have adequate stock to sacrifice a vial to the research gods if it comes to that. As always, please keep the discourse non-violent, and thanks so much for reading.
Please do! Very interesting assessment.
 
@randompersonrandom In my meanderings through TG I came across this PDF that seems to contradict some of the other stuff I've read here and on TG about which peps are compatible with BAC Saline and which aren't. I've read that Tirz is fine, but Reta is not. According to this, all GLPs and Cagri/Elora are the highest risk of any peptides, and that Epitalon, which I also intend to use regularly going forward is in the lowest risk category. All of the components of Klow are in the lower risk categories, but it doesn't address Klow itself and whether the blend might be more inherently unstable than the individual peps (the age-old pep debate rages back into the fore whether we like it or not) and thus problematic for your mom. I do intend to try BAC Saline with Klow at some point in the future once I procure a more substantial supply unless, as with Reta and Tesa, I have strong evidence to believe that it won't work. Like you, I have enough BAC to last me awhile if this experiment turns out to be star-crossed. If I can use BAC Saline for Mots-C and SS-31 that would be a win for me; anything else would be a bonus.

Bacteriostatic Saline vs "Naked" Lypholized Pucks

For my part, I definitely want to keep ISRs and costs to a minimum and keep control of my supply for the items I use regularly. Those are my main considerations here. This doesn't have any citations, so for all I know this person pulled this chart out of their armpit and dressed it up with some chemistry mumbo jumbo that is above my pay grade. Anyone with more knowledge in this area can feel free to weigh in on it.

@Alc23 Regarding ISR with Klow: I had a lot of issues with this as well when I first started using it, including ISRs that lasted several days. I've eliminated any injection site reactions with Klow and would suggest the following, in order of importance (in my sense of it anyway, your mileage may vary a bit): 1) Inject at a 90 degree angle into the ventral glute (side-butt). It doesn't seem like needle length matters for me, but I also don't use anything shorter than 8mm. I also don't use anything long enough that it would technically be considered intramuscular. I have noticed that with Klow, deeper is better, thus the 90 degree angle recommendation. (With Mots-C, FYI, I studiously avoid risk of anaphlaxis by using the shortest needle and keeping the injection as close to the skin surface as possible.) 2) Use a lot of BAC Water ie: 5ml for a vial of Klow 80 3) Let the mixture warm up close to room temperature before you inject and 4) Adding extra KPV if need be. Klow is one of the best tools in this space for the people who need it, so I hate to see people not use it because of ISRs. I feel the same way about Mots-C, just the injection technique I use is different as I discussed above.
 
@randompersonrandom In my meanderings through TG I came across this PDF that seems to contradict some of the other stuff I've read here and on TG about which peps are compatible with BAC Saline and which aren't. I've read that Tirz is fine, but Reta is not. According to this, all GLPs and Cagri/Elora are the highest risk of any peptides, and that Epitalon, which I also intend to use regularly going forward is in the lowest risk category. All of the components of Klow are in the lower risk categories, but it doesn't address Klow itself and whether the blend might be more inherently unstable than the individual peps (the age-old pep debate rages back into the fore whether we like it or not) and thus problematic for your mom. I do intend to try BAC Saline with Klow at some point in the future once I procure a more substantial supply unless, as with Reta and Tesa, I have strong evidence to believe that it won't work. Like you, I have enough BAC to last me awhile if this experiment turns out to be star-crossed. If I can use BAC Saline for Mots-C and SS-31 that would be a win for me; anything else would be a bonus.

Bacteriostatic Saline vs "Naked" Lypholized Pucks

For my part, I definitely want to keep ISRs and costs to a minimum and keep control of my supply for the items I use regularly. Those are my main considerations here. This doesn't have any citations, so for all I know this person pulled this chart out of their armpit and dressed it up with some chemistry mumbo jumbo that is above my pay grade. Anyone with more knowledge in this area can feel free to weigh in on it.

@Alc23 Regarding ISR with Klow: I had a lot of issues with this as well when I first started using it, including ISRs that lasted several days. I've eliminated any injection site reactions with Klow and would suggest the following, in order of importance (in my sense of it anyway, your mileage may vary a bit): 1) Inject at a 90 degree angle into the ventral glute (side-butt). It doesn't seem like needle length matters for me, but I also don't use anything shorter than 8mm. I also don't use anything long enough that it would technically be considered intramuscular. I have noticed that with Klow, deeper is better, thus the 90 degree angle recommendation. (With Mots-C, FYI, I studiously avoid risk of anaphlaxis by using the shortest needle and keeping the injection as close to the skin surface as possible.) 2) Use a lot of BAC Water ie: 5ml for a vial of Klow 80 3) Let the mixture warm up close to room temperature before you inject and 4) Adding extra KPV if need be. Klow is one of the best tools in this space for the people who need it, so I hate to see people not use it because of ISRs. I feel the same way about Mots-C, just the injection technique I use is different as I discussed above.
Thanks! I will definitely try that…I’m also adding part lido/epi to the mix and waiting for a pen to help with the glute injection🙏🤞🏼🍀 I’ve recently added kpv and think it’s gonna be a keeper! Waiting for an epi pen before I attempt mots-c, lol, but not joking!
 
I think a great test would be to analyze the degradation over 0/15/30/45 days of a select group of peptides and BAC Saline. Maybe Mots-C, Tirz, Reta, Epitalon and BPC. I think Reta may have been done, but I haven't seen that test, just assumptions that saline would be detrimental based on Reta's structure. I think some degradation tests of these peps exist with regular BAC, so this would be an excellent follow up.
 
As anyone who has been conducting research in this space in the last several months knows, the Gold Standard Hospira Bac Water has gone up substantially in price and become harder to get. When Amazon pulled all the BAC off their site and demand for Hospira made it pretty scarce for a few weeks and ultimately more costly, I decided to start researching alternatives. Like most people living in 2026, I don't particularly appreciate being price gouged; beyond that there were a few weeks there where people weren't sure where to get a good supply of BAC water to continue their research. This would not do for me. I had gotten a few bottles of Lambda just to see if there was any practical difference between it and the Hospira. For me, there isn't one that I can discern so far into my third bottle, other than that Lambda uses glass vials (quite preferable in my view) and that the bottles are tall and narrow and easy to knock over, which obviously isn't ideal. So once they got their crap together with their credit card processing, I ordered a bunch more Lambda, just in case the BAC water shit really hit the fan.

Like a lot of you, I find some peps to be spicy. For me, Mots-C is the worst of the worst in this regard; but also for me it's some of the most valuable research I do on an ongoing basis, so it behooves me to find a way to minimize ISRs. Higher dilution ratios do improve things, however even a 10mg/ml dilution using 4ml for a 40mg vial doesn't remove ISRs entirely with regular BAC. I could go up to 8, but under the current circumstances I would prefer to conserve BAC. I've been hearing a lot about BAC Saline in recent weeks and how and why it seems to improve ISRs, and it's definitely cheaper: I just bought some for less than $7 a bottle, and you can get a case of 24 for around $100.

Today began my research using BAC Saline for reconstituting Mots-C and Korean Glutathione (the pink Glutaone for the initiated). I reconned the Mots at 2ml per 40mg. It reconned crystal clear and dissolved completely in a couple of minutes. For the Gluta, I started with 3ml for a 1200mg vial; when that took awhile to dissolve, I added 1ml and that took care of the issue. Dissolved crystal clear. I don't have much if any issue with Gluta straight into the ventral glute, and if anything, it's even cleaner using BAC Saline. 1st dose was .5ml for a total of 150mg. Uneventful. The Mots-C is a bit more nuanced. The ISR is pretty minor so far (less than it would be with regular BAC, I think), and I will have a better sense of that tomorrow morning and over the next few days as I continue my work. I will recon the next vial with 4ml to see if that further reduces the ISR or eliminates it entirely.

If there is an interest in the community for this particular subject matter, I will be glad to update with any new and relevant information. If you have any questions about anything, feel free to ask. My understanding is that Reta and Tesa/Ipa are not compatible with BAC Saline, so at least for now, I'm not going to try those. I will be attempting with SS-31, Klow and its individual components, NAD, and probably a couple of others once I have adequate stock to sacrifice a vial to the research gods if it comes to that. As always, please keep the discourse non-violent, and thanks so much for reading.
I have nothing of value to add. I just want to give you kudos for using the word 'behooves', which I'd never heard before and had to Google. Every day really is a school day on this forum.
 
If there is an interest in the community for this particular subject matter, I will be glad to update with any new and relevant information.
There is definitely interest in it. I’ve gathered a list of compatible/incompatible compounds in this recent thread based on user experiences and am hopeful people will continue to share their experiences using BAC NaCl with different compounds so we can have a very thorough of successes and failures.

Bacteriostatic Sodium Chloride-Compatible Compounds
https://glp1forum.com/threads/bacteriostatic-sodium-chloride-compatible-compounds.19357/
 
...and I believe you have indicated that ther BAC Saline can/may help with ISR with some of the spicier pepes like GHK-Cu, Mots-c and SS31?...
Yes, it can help. Here’s why:
Spicy Peps - Regular BAC is hypotonic and forces water into the cells, which can cause some swelling and stinging. BAC SC is isotonic, matching human tissue osmolarity. This means there’s no gradient, so reduced swelling and pain.
 
Yes, it can help. Here’s why:
Thanks for providing a pointer back to the NaCL compatibility thread! I will give that a read through today!...I had just casually stumbled across a mention of BAC Saline a week or three ago, and what perked me of course was that BAC Saline would help with some of these peptides. Being a relative noob, I had never heard of this use/benefit, though I had seen BAC Saline listed on some of the supply websites. I immediately went to one of my go-to supply sites and ordered 3 bottles (I think they get here Monday). I was going to recon some GHK-Cu today as I was pretty settled on the KPV, BPC and TB500 protocols that I had been working on the last couple of months. I have Mots-C, SS-31 and NAD that I plan on using in a protocol with GHK, probably in the fall, but wanted to do a run of the GHK by itself first...I don't typically get ISR, but was a bit leery of GHK, glad to get some better information on the BAC Saline, thanks!... 👍
 
...and I believe you have indicated that ther BAC Saline can/may help with ISR with some of the spicier pepes like GHK-Cu, Mots-c and SS31?...

@Flash-BCR

Yes, as Dos-Dox indicates in more scientific terms in the post directly above regarding hypotonic versus isotonic. My most urgent goal vis a vis user experience with this research is to minimize or even eliminate ISR for Mots-C specifically. It's one of my most important tools and as almost anyone knows who has used it, it can be a pain in the ass. So many people are missing out on a tool that can really help them because the ISRs make it more trouble than it's worth.

I have never used GHK-CU by itself, but I have generally eliminated ISRs from Klow using the following technique as I outlined above:

1) Inject at a 90 degree angle into the ventral glute (side-butt). It doesn't seem like needle length matters for me, but I also don't use anything shorter than 8mm. I also don't use anything long enough that it would technically be considered intramuscular. I have noticed that with Klow, deeper is better, thus the 90 degree angle recommendation. (With Mots-C, FYI, I studiously avoid risk of anaphlaxis by using the shortest needle and keeping the injection as close to the skin surface as possible.) 2) Use a lot of BAC Water ie: 5ml for a vial of Klow 80 3) Let the mixture warm up close to room temperature before you inject and 4) Adding extra KPV if need be.

I would think these same rules apply as well or nearly as well to GHK-CU on its own.
 
@Flash-BCR This is a small excerpt of something interesting that @eidos said re: NaCL & MOTS-C, GHK-Cu and NAD in a post ( https://glp1forum.com/threads/need-help-finding-citric-acid-for-my-mots-c.20319/#post-211372 ) the other day:
For my personal use, I add 0.9% NaCl (without BA) to the SS31 MOTS-c or GHK-Cu, which last 5, 10, and 20 days. When using a pen, this reduces the risk of introducing bugs that can be introduced more likely with a syringe.
It doesn't sting anymore, and the isotonic solution has eliminated the hardening. (MOTSc in BA really hurts). If it reassures you, take some BAC Saline.
(FYI, he’s in EU where reconstitution solutions often don’t use benzyl alcohol)
 
Last edited:
@Flash-BCR This is a small excerpt of something interesting that @eidos said re: NaCL & MOTS-C, GHK-Cu and NAD in a post ( https://glp1forum.com/threads/need-help-finding-citric-acid-for-my-mots-c.20319/#post-211372 ) the other day:

(FYI, he’s in EU where reconstitution solutions often don’t use benzyl alcohol)
Very Nice!..and timely too! I think your posts were the ones that had a mention of NaCL and as I said above, my ears kinda perked up when I read it...Good stuff up here in the glp1forums interwebs today!... 👍
 
I’ve been using 0.9% NaCl (without BA) for a good month now for 2S31, MOTS-c, and GHK-Cu. No reaction, no more induration, no more bruising. I had already reduced the problems with GHK-Cu by switching to the 3x.05ml multipin, but it still sometimes caused bruising. I’m also diluting the MOTS-c more than before. Pens with 32G 4mm Embecta 5-bevel needles (formerly BD).

I'm sticking with BA for Tirz, Reta, and KPV, whose cartridges last longer.

In another thread, it was reported that NaCl works with Tirz; in fact, there's some in Kwikpens.
Reta seems to aggregate with salinity. We'll have to wait for the pharmaceutical formulations and the patent to find out more.
 
@Flash-BCR This is a small excerpt of something interesting that @eidos said re: NaCL & MOTS-C, GHK-Cu and NAD in a post ( https://glp1forum.com/threads/need-help-finding-citric-acid-for-my-mots-c.20319/#post-211372 ) the other day:

(FYI, he’s in EU where reconstitution solutions often don’t use benzyl alcohol)
Fortunately, I taught for a few years and got into the habit of repeating everything twice.
Fortunately, I taught for a few years and got into the habit of repeating everything twice.
 
I’ve been using 0.9% NaCl (without BA) for a good month now for 2S31, MOTS-c, and GHK-Cu. No reaction, no more induration, no more bruising. I had already reduced the problems with GHK-Cu by switching to the 3x.05ml multipin, but it still sometimes caused bruising. I’m also diluting the MOTS-c more than before. Pens with 32G 4mm Embecta 5-bevel needles (formerly BD).

I'm sticking with BA for Tirz, Reta, and KPV, whose cartridges last longer.

In another thread, it was reported that NaCl works with Tirz; in fact, there's some in Kwikpens.
Reta seems to aggregate with salinity. We'll have to wait for the pharmaceutical formulations and the patent to find out more.
My confusion was with Saline with and without BA...I am certain I read that from you regarding using Saline no BA with the Mots and thought maybe I had order some unusable Saline with the BA...but this thread cleared a lot of that up...

I have MOTS-c 10mg, so I may order some Saline w/o BA because at 10mg it is going to be 2-3 doses from a vial. I gather that in a week or two run from first pin to finishing a vial that bacterial growth probably won't be too bad if following a clean recon....Thanks!
 

Trending Topics

Forum Statistics

Threads
18,995
Posts
198,163
Members
63,162
Newest
wayzresearch
Back
Top Bottom