Systematic Review finds tirz 10 - 15 mg causes more weight loss than 2.4 mg (the max. dose) of sema while resulting in fewer side effects.

[keangkong]

This systematic review found that that tirzepatide 10-15 mg caused more weight loss than 2.4 mg of sema (the maximum dose) while resulting in fewer side effects. This is the first scientific thing that I read that confirmed what has been reported on social medial by people who have taken both drugs, that there are fewer side effects with tirz.

Singh, et al. (2025). Comparative efficacy and safety of semaglutide 2.4 mg and tirzepatide 5–15 mg in obesity with or without type 2 diabetes - A systematic review of Phase 3 clinical trials. Diabetes & Metabolic Syndrome - Clin. Res. & Rev.. 19(3) 103212, https://1drv.ms/b/c/d63cedb6db1eefc3/ETZkC_MjyIRDgt9wdaLvzRgBcWT620eaShB_iI-DL6GTeQ?e=e4ok0l.

 

[mraajr]

I thought we had known this for a while. 15% for Sema, 20% for Tirz, and 24-25% for Reta.

 

[keangkong]

I thought we had known this for a while. 15% for Sema, 20% for Tirz, and 24-25% for Reta.

This was the first I had heard from a scholarly source saying that tirz had less side effects. (I did find something else today that said the same thing.)

 

[juGGaKNot]

Systematic Review done on me shows me the same​

 

[flapjacks]

I know this is old but this thread has helped me decide what to use as far as future peps go. I'm on Sema currently but the constant nausea is gross.

 

[woundcarping]

I know this is old but this thread has helped me decide what to use as far as future peps go. I'm on Sema currently but the constant nausea is gross.

GIP really helps with that, it seems.

Today makes 24 weeks I’ve been on Tirz for a month then Reta… basically no nausea anywhere along the 60lb lost in that time.

 

[flapjacks]

GIP really helps with that, it seems.

Today makes 24 weeks I’ve been on Tirz for a month then Reta… basically no nausea anywhere along the 60lb lost in that time.

Have you tried any other peps? Like KLOW or Cag? If so, would you mind sharing your experience with side effects?

 

[Hawk_recon]

This systematic review found that that tirzepatide 10-15 mg caused more weight loss than 2.4 mg of sema (the maximum dose) while resulting in fewer side effects. This is the first scientific thing that I read that confirmed what has been reported on social medial by people who have taken both drugs, that there are fewer side effects with tirz.

Singh, et al. (2025). Comparative efficacy and safety of semaglutide 2.4 mg and tirzepatide 5–15 mg in obesity with or without type 2 diabetes - A systematic review of Phase 3 clinical trials. Diabetes & Metabolic Syndrome - Clin. Res. & Rev.. 19(3) 103212, https://1drv.ms/b/c/d63cedb6db1eefc3/ETZkC_MjyIRDgt9wdaLvzRgBcWT620eaShB_iI-DL6GTeQ?e=e4ok0l.

Nice find, thanks for posting!

 

[dancs]

Have you tried any other peps? Like KLOW or Cag? If so, would you mind sharing your experience with side effects?

Never did KLOW. IMO it's best to take the peps separately.

I did take cag though and boy does that hit you like a TRUCK. If you do get cag, just make sure the pH level is balanced because if you're not careful, that b*tch STINGS.

6'2 at 200lbs, I took 0.5mg of cag and my first and second doses were nuts. I don't fully remember but you're not supposed to take high doses of cag and not for too long --- don't remember why, so you gotta do your own research!

If you're looking for an alternative where you don't need to do another pinning, I would recommend you check out tesofensine!

 

[Airborne Daddy]

I thought we had known this for a while. 15% for Sema, 20% for Tirz, and 24-25% for Reta.

Right...would also explain why they studied upping sema to 7.5mg, to stay relevent. Never heard the end findings or did it cause pancreatitis. Im guessing if it worked out and was approved wed be bombarded with tv commercials.

 

[UnripeLadel]

I thought we had known this for a while. 15% for Sema, 20% for Tirz, and 24-25% for Reta.

But were the side effects profiles as confirmed too?

Either way, I think a systematic review is just studying the results of previous tests and coming to a more structured conclusion, so the more high-level analysis of studies the better and more reason for us to trust them

 

[Standish]

Sema is so primitive...