Systematic Review finds tirz 10 - 15 mg causes more weight loss than 2.4 mg (the max. dose) of sema while resulting in fewer side effects.

[keangkong]

This systematic review found that that tirzepatide 10-15 mg caused more weight loss than 2.4 mg of sema (the maximum dose) while resulting in fewer side effects. This is the first scientific thing that I read that confirmed what has been reported on social medial by people who have taken both drugs, that there are fewer side effects with tirz.

Singh, et al. (2025). Comparative efficacy and safety of semaglutide 2.4 mg and tirzepatide 5–15 mg in obesity with or without type 2 diabetes - A systematic review of Phase 3 clinical trials. Diabetes & Metabolic Syndrome - Clin. Res. & Rev.. 19(3) 103212, https://1drv.ms/b/c/d63cedb6db1eefc3/ETZkC_MjyIRDgt9wdaLvzRgBcWT620eaShB_iI-DL6GTeQ?e=e4ok0l.

 

[mraajr]

I thought we had known this for a while. 15% for Sema, 20% for Tirz, and 24-25% for Reta.

 

[keangkong]

I thought we had known this for a while. 15% for Sema, 20% for Tirz, and 24-25% for Reta.

This was the first I had heard from a scholarly source saying that tirz had less side effects. (I did find something else today that said the same thing.)