Tesamorelin STINGS

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Ymachado

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-Hi so I ordered my Tesa and I was so excited to try it considering the possibility it could help me shred abdominal fat, but holy cow, the injection stings, I never felt anything like that while taking Tirzepatide, I diluted 5mg in 0.5 ml of bac water, I wonder If I should dilute further or if anyone has any advice.
-I read this is common with Tesamorelin but geez.
-The current recommended dosage I've seen is 2mg a day(I only did 1mg) 5 days on 2 days off.

Honestly after seeing how much it stings and the price point, belly fat doesn't sound too bad anymore.

If anyone has any advice, maybe dilute the solution more. Will gladly take it, hoping to hear about others' experiences.
 
Ymachado said:
Hi so I ordered my Tesa and I was so excited to try it considering the possibility it could help me shred abdominal fat, but holy cow, the injection stings, I never felt anything like that while taking Tirzepatide, I diluted 5mg in 0.5 ml of bac water, I wonder If I should dilute further or if anyone has any advice.
-I read this is common with Tesamorelin but geez.
-The current recommended dosage I've seen is 2mg a day(I only did 1mg) 5 days on 2 days off.

Honestly after seeing how much it stings and the price point, belly fat doesn't sound too bad anymore.

If anyone has any advice, maybe dilute the solution more. Will gladly take it, hoping to hear about others' experiences.
Click to expand...
I've just looked that up, because I'm waiting on some from the mail and didn't think of checking that before trying, but here's what I found :
  • Inject slowly and at room temperature
  • Dilute more
  • Adjust pH with buffer
 
You can absolutely dilute it with more BAC for a lesser sting. Personally, I've found with all spicy peptides, the longer I use it the less I have any ISRs or stinging. Keep to it, your body will adjust.
 
ThePepPlanner said:
You can absolutely dilute it with more BAC for a lesser sting. Personally, I've found with all spicy peptides, the longer I use it the less I have any ISRs or stinging. Keep to it, your body will adjust.
Click to expand...


This. I've been researching tesa for 6 weeks now and the reactions seemed to stop. I would get a mild isr initially. Longer needles may help too
 
scarywood75 said:
I've just looked that up, because I'm waiting on some from the mail and didn't think of checking that before trying, but here's what I found :
  • Inject slowly and at room temperature
  • Dilute more
  • Adjust pH with buffer
Click to expand...
I was told by the vendor not to adjust the pH it may cause it to gel. Its supposed to be at a lower ph. I think it's around 4.
 
Vicki said:
I was told by the vendor not to adjust the pH it may cause it to gel. Its supposed to be at a lower ph. I think it's around 4.
Click to expand...
If the pH is 4, that's definitely why it stung so hard, that's very acidic for the body
 
Ymachado said:
-Hi so I ordered my Tesa and I was so excited to try it considering the possibility it could help me shred abdominal fat, but holy cow, the injection stings, I never felt anything like that while taking Tirzepatide, I diluted 5mg in 0.5 ml of bac water, I wonder If I should dilute further or if anyone has any advice.
-I read this is common with Tesamorelin but geez.
-The current recommended dosage I've seen is 2mg a day(I only did 1mg) 5 days on 2 days off.

Honestly after seeing how much it stings and the price point, belly fat doesn't sound too bad anymore.

If anyone has any advice, maybe dilute the solution more. Will gladly take it, hoping to hear about others' experiences.
Click to expand...
I go 1.0mL dilution at least.
I use peptidecalc.com to run 1.5mL or 2.0mL or 2.5mL to see what gets my dose to a whole number on my syringe. 5 or 10 units.
Last time I use 2mL in 10mg to pull 20 units for 2mg… anyways, long way to stay: use a bit more BAC
 
Hello all! What concentration would be ideal to reduce the stinging effect. I see a comment above that a 1ml concentration is ideal. Wit ha 10mg Vial and a 1mg dose, that means adding 10mL of bac water and drawing 100 units per day for the dose. That feels like alot.

For those who have taken Tesa for awhile, what amount of bac water do you add to a 10mg vial to reduce the sting?
 

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Get some litmus paper and keep diluting until you get it to reasonable pH. You may want a bigger sterile vial to hold the reconstituted solution. Might as well filter it if you are not filtering yet. Keep in mind that if you decide to switch to a pen later, most pens don't go over 60 units per injection.
 
squig33 said:
Hello all! What concentration would be ideal to reduce the stinging effect. I see a comment above that a 1ml concentration is ideal. Wit ha 10mg Vial and a 1mg dose, that means adding 10mL of bac water and drawing 100 units per day for the dose. That feels like alot.

For those who have taken Tesa for awhile, what amount of bac water do you add to a 10mg vial to reduce the sting?
Click to expand...
if a 1ml concentration is ideal, why are you making it 10ml? They don't mean that level of concentration for each injection, just the 10mg vial in general.

I just do 2ml per 10mg and do 40 units (and 10 units of ipamorelin for 300ish mcg) each injection. Very mild sting.
 
hexagonal said:
if a 1ml concentration is ideal, why are you making it 10ml? They don't mean that level of concentration for each injection, just the 10mg vial in general.

I just do 2ml per 10mg and do 40 units (and 10 units of ipamorelin for 300ish mcg) each injection. Very mild sting.
Click to expand...
@hexagonal Well, I do not know if a 1ml concentration is ideal. That is what I am asking because I don't have any real world experience with Tesa.

What you said is helpful, so at a 5 mg/mL concentration you are just feeling a mild sting. It was just someone above mentioned going down to a 1 mg/mL concentration and that would require a TON of bac water and that felt funny to me. Your comment confirms that the concentration does not need to be that low.

So is your total dose of IPA 0.5 mg per day?

1733252336397.png
 
stickfigure said:
Get some litmus paper and keep diluting until you get it to reasonable pH. You may want a bigger sterile vial to hold the reconstituted solution. Might as well filter it if you are not filtering yet. Keep in mind that if you decide to switch to a pen later, most pens don't go over 60 units per injection.
Click to expand...

Got it! I am not ready to plunge in on this yet just doing research first. When I do I will filter I do that with Triz already no reason not to just in case. Filters are cheap. With Triz I did not look at the pH before and have not experienced any stinging so managing this injection effect is new to me. Do you usually do that process with your first vial of a peptide to dial in your recon process?
 
squig33 said:
@hexagonal Well, I do not know if a 1ml concentration is ideal. That is what I am asking because I don't have any real world experience with Tesa.

What you said is helpful, so at a 5 mg/mL concentration you are just feeling a mild sting. It was just someone above mentioned going down to a 1 mg/mL concentration and that would require a TON of bac water and that felt funny to me. Your comment confirms that the concentration does not need to be that low.

So is your total dose of IPA 0.5 mg per day?

View attachment 4116
Click to expand...
I reconstitute my ipamorelin at 5mg/1.5ml and add .5ml to the 10mg/2ml vial of tesamorelin. I save the remain 1ml for week 2 and 3. This puts my total units at 50 on my syringe and should get me roughly 2mg of tesamorelin and 334mcg of ipamorelin. I take the combined injection at night a couple of hours before bed.

I'm not super concerned with being a bit off on the ipamorelin dosing vs the arget of 300mcg.

I'm having some bloodwork done later this week (shoutout to fitomics and their great pricing) to take a look at how my insulin and igf-1 are looking and will adjust my dosing if there is anything of concern there.
 
squig33 said:
Hello all! What concentration would be ideal to reduce the stinging effect. I see a comment above that a 1ml concentration is ideal. Wit ha 10mg Vial and a 1mg dose, that means adding 10mL of bac water and drawing 100 units per day for the dose. That feels like alot.

For those who have taken Tesa for awhile, what amount of bac water do you add to a 10mg vial to reduce the sting?
Click to expand...
I add 1.5ml to 10mg bottle. I take 30 units or 0.3ml for a 2mg dose. I usually mix two vials to fill a pen cartridge.
 
I am using 10mg QSC Tesa from the green lid GB in 2.5 mg/ml solution. I add 4 ml of Hospira BAC to the vial and inject 40 units for 1mg. No pain or ISR after injection. I am filtering the resulting solution into two pen cartridges, 2ml each.

Ps. I know about poor test results of this batch
 
As others have said, I mix my tesa with 2ml or bac water to 6mg and experience no sting at all. I've been driving tesa for four months.
 
1mg dose from a 10mg reconstituted with 2.5ml of bac water stings pretty bad.
 
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