TESOFENSINE

Dee X said:
Those responses are pretty uncharacteristic for Milos. He's not wrong about some chemical similarities, but he's also being a bit tone-deaf.

If you've ever tried the two, you'd know they're not similar in effects at all.

Milos, do you go around telling people who need to take morphine that they're on "heroin light"? Those are even closer chemically.
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As The Dude once said: “You’re not wrong, Walter. You’re just an asshole.”
 
Dee X said:
Those responses are pretty uncharacteristic for Milos. He's not wrong about some chemical similarities, but he's also being a bit tone-deaf.

If you've ever tried the two, you'd know they're not similar in effects at all.

Milos, do you go around telling people who need to take morphine that they're on "heroin light"? Those are even closer chemically.
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c'mon guys I didn't say anything so bad, to be for instance even close to Tracy's everyday language, why are you so sensitive?
I really just tried to be little bit funny based on the fact the compound is in fact from the same family as cocaine, so that I just call it "coke light" is not far from the truth and absolutely not any personal attack against anyone. Seriously c'mon, whats the issue here?
 
milos said:
c'mon guys I didn't say anything so bad, to be for instance even close to Tracy's everyday language, why are you so sensitive?
I really just tried to be little bit funny based on the fact the compound is in fact from the same family as cocaine, so that I just call it "coke light" is not far from the truth and absolutely not any personal attack against anyone. Seriously c'mon, whats the issue here?
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Tracy is known for being an asshole, you're better than that. We respect you more.
 
I check back my original post wasn't even answer to @peptideusername
never mind, not worth my time creating some new drama around total nonsense
 
peptideusername said:
“we” is a stretch here.
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i don't think so. She's talking about the forum in general. He has a lot of knowledge and helps out a lot.

Edit: I don't mean to get in the middle of this, but milos caught me overdosing myself by 10x ( i know....i'm an idiot) so i have some firsthand experience and am grateful for his presence.
 
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raw_oyster_eater said:
i don't think so. She's talking about the forum in general. He has a lot of knowledge and helps out a lot.

Edit: I don't mean to get in the middle of this, but milos caught me overdosing myself by 10x ( i know....i'm an idiot) so i have some firsthand experience and am grateful for his presence.
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support from @raw_oyster_eater means a lot to me! it wasn't easy to gain respect and trust from him! but seriously we have more important things to discuss than creating some new dramas
☮️
 
BeardedGuy said:
So but wait… is Tesofesine going to be addicting? Physically or mentally?
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No, not according to any clinical trials. The mechanisms are completely different. It also does not get you high, and it lasts in your system for a long time.

You can probably misuse it if you try hard enough since it affects dopamine, just like anything else that affects dopamine, but you're going to have a bad time.

For short read: https://en.m.wikipedia.org/wiki/Tesofensine

For long reads, look at PubMed and the patents.

This is actually why I was so against calling it "coke light".

(Disclaimer: we haven't seen phase 3 trials data. Though, my RSs have not experienced anything like that)
 
Dee X said:
No, not according to any clinical trials. The mechanisms are completely different. It also does not get you high, and it lasts in your system for a long time.

You can probably misuse it if you try hard enough since it affects dopamine, just like anything else that affects dopamine, but you're going to have a bad time.

For short read: https://en.m.wikipedia.org/wiki/Tesofensine

For long reads, look at PubMed and the patents.

This is actually why I was so against calling it "coke light".

(Disclaimer: we haven't seen phase 3 trials data. Though, my RSs have not experienced anything like that)
Click to expand...
Understood much better now, thanks. Love this forum.
 
Dee X said:
No, not according to any clinical trials. The mechanisms are completely different. It also does not get you high, and it lasts in your system for a long time.

You can probably misuse it if you try hard enough since it affects dopamine, just like anything else that affects dopamine, but you're going to have a bad time.

For short read: https://en.m.wikipedia.org/wiki/Tesofensine

For long reads, look at PubMed and the patents.

This is actually why I was so against calling it "coke light".

(Disclaimer: we haven't seen phase 3 trials data. Though, my RSs have not experienced anything like that)
Click to expand...
pubmed.ncbi.nlm.nih.gov

Subjective and objective effects of the novel triple reuptake inhibitor tesofensine in recreational stimulant users - PubMed

Tesofensine is a (triple) reuptake inhibitor of noradrenaline, dopamine, and serotonin that is in development for the treatment of obesity. The abuse potential of triple reuptake inhibitors is not yet known, and so this study was undertaken to evaluate the potential abuse-related effects of...
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

Yeah, not apparently addictive… good news.
 
I looked at adding Teso to my trial research but I am concerned with the heart rate increase (adding to the impact of the Tirz HR increase I already have) and the potential for variations in tablet strength.

From what I have read many start on 125mcg (which I would start with) which means cutting the pill in quarters. My concern is dosing/strength inconsistency from one tablet to the next and even within each 1/4 tablet. Similar to many of the people ODing on fentanyl tablets. One user is fine and the next user OD's from the same batch. If you have ever tried to mix salt and pepper (perfect for smoking a brisket) it is very difficult to get the mix to come out evenly. This is what I imagine happening in the UGL's making these tabs (or capsules). I may still give it a shot though, maybe when I am in maintenance.

Does anyone get several tabs tested from each bottle/batch? Janoshik was the only lab that I found that offers it.
 
Dee X said:
No, not according to any clinical trials. The mechanisms are completely different. It also does not get you high, and it lasts in your system for a long time.

You can probably misuse it if you try hard enough since it affects dopamine, just like anything else that affects dopamine, but you're going to have a bad time.

For short read: https://en.m.wikipedia.org/wiki/Tesofensine

For long reads, look at PubMed and the patents.

This is actually why I was so against calling it "coke light".

(Disclaimer: we haven't seen phase 3 trials data. Though, my RSs have not experienced anything like that)
Click to expand...
pubmed.ncbi.nlm.nih.gov

Subjective and objective effects of the novel triple reuptake inhibitor tesofensine in recreational stimulant users - PubMed

Tesofensine is a (triple) reuptake inhibitor of noradrenaline, dopamine, and serotonin that is in development for the treatment of obesity. The abuse potential of triple reuptake inhibitors is not yet known, and so this study was undertaken to evaluate the potential abuse-related effects of...
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
EDIT: @BeardedGuy found it first, no it will not be addictive any more compared to antidepressants
 
GimmeABreak said:
I looked at adding Teso to my trial research but I am concerned with the heart rate increase (adding to the impact of the Tirz HR increase I already have) and the potential for variations in tablet strength.

From what I have read many start on 125mcg (which I would start with) which means cutting the pill in quarters. My concern is dosing/strength inconsistency from one tablet to the next and even within each 1/4 tablet. Similar to many of the people ODing on fentanyl tablets. One user is fine and the next user OD's from the same batch. If you have ever tried to mix salt and pepper (perfect for smoking a brisket) it is very difficult to get the mix to come out evenly. This is what I imagine happening in the UGL's making these tabs (or capsules). I may still give it a shot though, maybe when I am in maintenance.

Does anyone get several tabs tested from each bottle/batch? Janoshik was the only lab that I found that offers it.
Click to expand...
Here is an example of a recent Janoshik test of four 500mg tablets from Wuhan presumably from the same batch (all four were listed on the same test):

1729520877438.png


This seems like a huge variation from one tablet to the next and also doesn't account for the potential variation within each tab when you split it in four.

Does this dose variation impact your research results or does the long half-life sort of even it all out?
 
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